thiourea and Intestinal-Pseudo-Obstruction

A controlled trial of intraperitoneal noxytiolin (Noxiflex) solution in patients with peritonitis due to perforated appendicitis is reported. No significant difference was found in the incidence of complications between the treated and a control group, raising doubts as to whether this substance is of value when used intraperitoneally in peritonitis.

Topics: Administration, Topical; Appendectomy; Appendicitis; Clinical Trials as Topic; Female; Humans; Intestinal Perforation; Intestinal Pseudo-Obstruction; Male; Noxythiolin; Peritonitis; Surgical Wound Infection; Thiourea

A new stimulator of intestinal peristalsis-guthymine (guanylthiourea) was used experimentally and clinically for treatment of the bowel paresis in peritonitis. Preliminary, in experiments on 53 rabbits with colibacillar peritonitis an efficacy of guthymine was compared with other stimulators of the gastrointestinal tract: proserine, a hypertonic solution of sodium chloride and sorbitol. Guthymine was found to be the most effective drug. Clinically, in 23 of 33 patients with intestinal paresis a drip administration of 15-50 mg/Kg of guthymine would provide for aborting the signs of paresis. In 8 patients a moderately pronounced effect was noted. In 2 cases the use of guthimine failed to produce any positive effects.

Topics: Animals; Guanine; Humans; Injections, Intravenous; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Peristalsis; Peritonitis; Rabbits; Thiourea