thiourea has been researched along with Insulinoma* in 1 studies
1 other study(ies) available for thiourea and Insulinoma
| Article | Year |
|---|---|
Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1.
1. Alloxan and its auto-oxidation product hydrogen peroxide (H2O2) irreversibly depolarize insulinoma cells by opening a non-selective cation channel. The channel opened is characterized by a linear current-voltage relation with a conductance of approximately 70 pS and very slow kinetics (of the order of seconds). 2. Cells are protected against the alloxan-induced channel opening and consequent cell depolarization by the presence of H2O2 and hydroxyl radical scavengers. 3. The free radical-activated non-selective cation channel is not operative in isolated patches but can be activated by the application of beta-NAD+ to the cytoplasmic aspect of the membrane. Topics: Alloxan; Animals; Cell Polarity; Cysteine; Free Radical Scavengers; Hydrogen Peroxide; Insulinoma; Islets of Langerhans; Membrane Potentials; Niacinamide; Patch-Clamp Techniques; Rats; Reactive Oxygen Species; Thiourea; Tumor Cells, Cultured | 1997 |