thiourea and Infertility--Female

The effectiveness of systemic corticosteroids in the prevention of adhesion formation and reformation has been recently questioned, on the grounds of non randomized studies. Noxythiolin has been tried in animal experiments, but never in the human. In this paper, a randomized study of the effect of dexamethasone and/or noxythiolin versus no treatment has been conducted by the Group d'Etude des Adhérences Pelviennes. 126 patients have been operated upon by microsurgery (salpingectomy and/or salpingolysis). Adhesions have been assessed by a score derived from the American Fertility Society endometriosis classification, before operation and by laparoscopy 3 to 6 months later. The mean improvement on adhesion score was 23.2 in the corticosteroid treated group, 19.3 in the noxythiolin group, 15.7 in the noxythiolin and corticosteroid group, 10.2 in the control group. 40% of patients (13 out of 32) in the corticosteroid group, versus 26% (5 out of 29) in the noxythiolin and corticosteroid group and 19% (6 out of 31) in the control group (p less than 0.02) became pregnant. No adverse effect has been noted. These results support the use of corticosteroids in infertility surgery.

Topics: Dexamethasone; Fallopian Tube Diseases; Female; Humans; Infertility, Female; Noxythiolin; Postoperative Complications; Prospective Studies; Random Allocation; Thiourea; Tissue Adhesions

Genotoxic activation of hydrazine (HZ), two symmetrical dialkylhydrazines, namely, 1,2dimethylhydrazine and 1,2-diethylhydrazine (SDMH and SDEH), thiourea (TU) and ethylene thiourea (ETU) has been evaluated by means of the w/w + somatic assay of Drosophila. Both low bioactivation insecticide-susceptible (IS) and high biotransformation insecticide-resistant (IR) strains were used. The combined application of insecticide-susceptible and insecticide-resistant strains should, in principle, detect somatic cell recombinagens in the Drosophila melanogaster in vivo w/w + assay. The IS strain was more susceptible to toxicity induced by the test chemicals than the IR stocks. Its performance in the biotransformation of the chemicals tested was rather poor. TU was inactive in all strains. With the active compounds, spot frequencies increased approximately linearly with dose for each spot type. SDEH gave a strong positive result in all three female genotypes exposed. HZ, ETU and SDMH were overall weakly positive in the IR strain Haag-79 (HG-R). Interestingly, ETU was clearly positive in the IR Hikone-R (HK-R) strain. A comparison of the recombinagenic potencies between the active and the weakly positive compounds, and among strains, showed pronounced genotype-dependent differences between the low and the high bioactivation strains. The ability of Drosophila to express several procarcinogens in relation to insecticide-resistance after activation catalyzed by CYP450 enzymes is discussed.

Topics: 1,2-Dimethylhydrazine; Animals; Dose-Response Relationship, Drug; Drosophila melanogaster; Ethylenethiourea; Eye Color; Female; Heterozygote; Hydrazines; Infertility, Female; Insecticide Resistance; Mutagenicity Tests; Recombination, Genetic; Thiourea

The primary target of thiourea in female Sarcophaga are the follicles in the ovarioles. The follicle cells as a result become syncytial and their nuclei get pycnotic, inhibiting the transport of nutrient material into the nurse cells and of yolk into the oocytes. The subnormal eggs produced are not viable.

Topics: Animals; Diptera; Female; Infertility, Female; Ovarian Follicle; Ovary; Pest Control; Thiourea

Topics: Animals; Female; Infertility; Infertility, Female; Liver Cirrhosis, Experimental; Thiourea; Vitamin E