thiourea and Hand-Dermatoses

Topics: Adult; Dermatitis, Allergic Contact; Dermatitis, Occupational; Diagnosis, Differential; Female; Hand Dermatoses; Humans; Jewelry; Patch Tests; Thiourea

Topics: Adult; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Hand Dermatoses; Humans; Neoprene; Patch Tests; Thiourea; Young Adult

Topics: Adult; Computer Peripherals; Dermatitis, Allergic Contact; Female; Hand Dermatoses; Humans; Patch Tests; Rubber; Thiourea

About 21% of the patients with occupational contact dermatitis registered in the Information Network of Departments of Dermatology (IVDK) in the years 1995-2001 were patch tested due to suspected rubber glove allergy. We analysed reaction frequencies to thiurams, dithiocarbamates, mercaptobenzothiazole (MBT) and its derivatives, thioureas, and 1,3-diphenylguanidine (1,3-DPG). Thiurams were by far the most frequent rubber allergens in these patients (16.2% positive reactions, age- and sex-standardized), and the reaction frequency showed a decline from 20.9% in 1997 to 12.8% in 2000. However, this trend was not statistically significant, and was followed by an increase to 16.5% in 2001. All other rubber allergens showed no time trend at all. Although, according to manufacturers' information, the use of dithiocarbamates and MBT derivatives in rubber glove production increased in recent years, these allergens elicited positive reactions in only about 3% of the patients tested, and showed no increasing trend. Thioureas and 1,3-DPG are not widely used in rubber glove production, and play only a minor role in rubber glove contact allergy. Most of the positive reactions to 1,3-DPG are probably false-positive, irritant reactions.

Topics: Adult; Allergens; Benzothiazoles; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Germany; Gloves, Protective; Hand Dermatoses; Humans; Latex Hypersensitivity; Male; Thiazoles; Thiocarbamates; Thiourea; Thiram

Topics: Adult; Allergens; Dermatitis, Allergic Contact; Dermatitis, Occupational; Diagnosis, Differential; Female; Hand Dermatoses; Humans; Patch Tests; Thiourea

Topics: Adult; Copying Processes; Dermatitis, Allergic Contact; Dermatitis, Occupational; Diazonium Compounds; Facial Dermatoses; Hand Dermatoses; Humans; Male; Paper; Thiourea

A 35-year-old machinist developed hand eczema from contact allergy to dibutylthiourea, a compound found in a paint and glue remover. Light and electron microscopy of his positive patch test was consistent with allergic contact dermatitis, showing Langerhans cell-mononuclear cell contacts in the epidermis.

Topics: Adult; Biopsy; Dermatitis, Occupational; Hand Dermatoses; Humans; Male; Microscopy, Electron; Patch Tests; Skin; Skin Tests; Thiourea

Topics: Adult; Azo Compounds; Dermatitis, Occupational; Hand Dermatoses; Humans; Male; Paper; Printing; Thiourea