thiourea and Gastritis

Aspirin, ketoprofen, ibuprofen, and naproxen all produced acute gastric erosions in rats. Aspirin produced significantly more erosions than ketoprofen, ibuprofen, or naproxen. There was no significant difference between the effects of ketoprofen, ibuprofen, and naproxen. Aspirin and naproxen produced a synergistic effect at higher dosage. Metiamide and cimetidine were effective in preventing this type of experimental acute erosive gastritis.

Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastritis; Guanidines; Histamine H2 Antagonists; Ibuprofen; Imidazoles; Ketoprofen; Male; Metiamide; Naproxen; Rats; Thiourea

Aspirin or bile administered by esophageal intubation to rats produced acute gastric erosions. These injuries could have been prevented by the prior administration by esophageal intubation of metiamide, a histamine H2 receptor antagonist that is known to inhibit gastric acid secretion.

Topics: Acute Disease; Animals; Aspirin; Bile Acids and Salts; Gastric Mucosa; Gastritis; Male; Metiamide; Rats; Thiourea

Topics: Acute Disease; Animals; Antacids; Capsaicin; Fatty Acids, Unsaturated; Gastritis; Guanidines; Imidazoles; Male; Metiamide; Rats; Thiourea

Topics: Acute Disease; Animals; Antacids; Gastritis; Guanidines; Imidazoles; Male; Metiamide; Rats; Thiourea

The H-2-blocking antihistamine metiamide was used to treat 14 episodes of bleeding from the stomach or duodenum in eleven patients. In 11 instances bleeding was due to erosive gastritis or duodenitis and bleeding promptly ceased after one or two doses of 300 mg at 6 h intervals and did not recur as long as the drug was continued. In the 2 instances in which bleeding continued, chronic ulcers had eroded into major blood-vessels. There were no complications from the drug even in five patients with severe bone-marrow suppression after renal transplantation. Metiamide seems to be a safe and highly effective agent in the control of bleeding due to erosive gastritis.

Topics: Adolescent; Adult; Aged; Child; Duodenum; Enteritis; Female; Gastric Juice; Gastritis; Gastrointestinal Hemorrhage; Humans; Intubation, Gastrointestinal; Male; Metiamide; Middle Aged; Peptic Ulcer Hemorrhage; Stress, Physiological; Thiourea