thiourea and Foot-Dermatoses

Topics: Carbamates; Clothing; Dermatitis, Allergic Contact; Foot Dermatoses; Glucocorticoids; Guanidines; Humans; Male; Middle Aged; Neoprene; Patch Tests; Severity of Illness Index; Symptom Flare Up; Thiocarbamates; Thiourea

A 12-year-old boy presented with severe, bilateral foot dermatitis. Extended patch testing was performed, revealing a significant positive reaction to mixed dialkyl thioureas. A thorough review of his history revealed that he was likely being exposed through his neoprene taekwondo shoes. After implementation of allergen avoidance measures, his dermatitis resolved. This case emphasizes awareness of potential allergen exposures and offers helpful avoidance strategies.

Topics: Allergens; Child; Dermatitis, Allergic Contact; Follow-Up Studies; Foot Dermatoses; Humans; Male; Patch Tests; Risk Assessment; Severity of Illness Index; Shoes; Thiourea

Topics: Blister; Dermatitis, Allergic Contact; Foot Dermatoses; Humans; Male; Middle Aged; Neoprene; Patch Tests; Shoes; Thiourea; Time Factors

Topics: Dermatitis, Contact; Female; Foot Dermatoses; Humans; Middle Aged; Phenylenediamines; Purpura; Shoes; Thiourea

Ten patients with severe foot dermatitis were found to be highly allergic to innersole material prepared by Spenco Medical Corporation and used in Nike athletic shoes. Contact allergy testing showed sensitivity to ethyl butyl thiourea, a chemical accelerator in some neoprene (polychioroprene) rubber products. The dermatitis was recalcitrant and in many cases persisted long after discontinuance of wearing Nike shoes, raising the concern that traces of ethyl butyl thiorea or cross-reacting chemicals may be present in other footwear.

Topics: Adult; Allergens; Dermatitis, Contact; Foot Dermatoses; Humans; Male; Patch Tests; Shoes; Thiourea