thiourea and Escherichia-coli-Infections

The intraperitoneal instillation of noxythiolin in the treatment of peritonitis is widespread in clinical practice despite contradictory evidence as to its efficacy. In this light the value of noxythiolin was reappraised by studying its effect in guinea-pigs and mice with induced bacterial peritonitis. Treatment with a 1% solution of noxythiolin reduced the mortality rate of mice by 14% (P less than 0.1). The guinea-pig model proved unreliable giving inconsistent mortality rates throughout. Further studies are required to determine the optimum dose and concentration of noxythiolin while the search for more effective intraperitoneal antiseptics should continue.

Topics: Animals; Escherichia coli Infections; Female; Guinea Pigs; Injections, Intraperitoneal; Mice; Noxythiolin; Peritonitis; Thiourea

The clinically used topical antibiotic ointments, gentamicin 0.1%, oxytetracycline 3% w/polymyxin 0.1% and chloramphenicol 2% and an experimental preparation, 10-undecen-1-yl thiopseudourea iodide (AHR-1911) were studied for anti-infective action applied externally on the skin of mice inoculated subcutaneously with S. aureus and E. coli. In both infections statistically significant difference was encountered between curative and "clinical" healing rate in the case of the less effective preparations and/or dosages. The method appears suitable to establish and to compare the in vivo activity of ointments. This is not directly related to that of the aqueous drug solutions. AHR-1911, a powerful inhibitor of nucleic acid and protein synthesis, showed a bimodal action, with maximal effectiveness at 0.12-0.25% concentration, due presumably to the anti-inflammatory effect of higher concentrations. Direct evidence for the absorption of the drug from the application site was obtained using 14C labeled AHR-1911.

Topics: Abscess; Administration, Topical; Animals; Drug Combinations; Drug Evaluation; Escherichia coli Infections; Gentamicins; Isothiuronium; Mice; Ointments; Oxytetracycline; Polymyxins; Skin Ulcer; Staphylococcal Infections; Thiourea

Topics: Amphotericin B; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Candida albicans; Candidiasis; Escherichia coli; Escherichia coli Infections; Mice; Neomycin; Nystatin; Penicillins; Polymyxins; Staphylococcal Infections; Streptomycin; Tetracycline; Thiourea; Undecylenic Acids

Topics: Aged; Ampicillin; Anti-Infective Agents, Local; Arthritis, Rheumatoid; Cloxacillin; Escherichia coli; Escherichia coli Infections; Female; Humans; Joint Diseases; Joint Prosthesis; Knee; Knee Joint; Methanol; Necrosis; Radiography; Splints; Therapeutic Irrigation; Thiourea; Urinary Tract Infections

Topics: Animals; Bacteriuria; Escherichia coli; Escherichia coli Infections; Female; Germ-Free Life; Hydroxyurea; Injections, Intraperitoneal; Kidney; Mice; Mice, Inbred ICR; Proteus Infections; Proteus mirabilis; Pyelonephritis; Thiourea; Urease

Comparison of the action of TURISYNCHRON and its zinc complex SUISYNCHRON in mice, rats and dogs showed that neither compound interfered with the implantation process in rats. After oral administration, blood concentrations were lower with SUISYNCHRON than with TURISYNCHRON. The zinc complex was broken down in the acid medium of the stomach, and absorbed in the duodinum or in distal segments of the intestine. Metallibure did not affect on phagocytosis not the course of infections with Escherichia coli or Erysipelothrix insidosa. Both compounds had a thymolytic action, which did not mimic the effect of cofticosteriods.

Topics: Adrenal Cortex Hormones; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Drug Interactions; Erysipelothrix Infections; Escherichia coli Infections; Female; Glucose Tolerance Test; Intestinal Absorption; Male; Methallibure; Mice; Phagocytosis; Pregnancy; Pregnancy, Animal; Rats; Thiourea; Thymus Gland; Zinc

Topics: Cystitis; Drug Combinations; Escherichia coli; Escherichia coli Infections; Humans; Hypertrophy; Male; Prostatic Hyperplasia; Sulfadiazine; Sulfonamides; Thiourea