thiourea and Appendicitis

A controlled trial of intraperitoneal noxytiolin (Noxiflex) solution in patients with peritonitis due to perforated appendicitis is reported. No significant difference was found in the incidence of complications between the treated and a control group, raising doubts as to whether this substance is of value when used intraperitoneally in peritonitis.

Topics: Administration, Topical; Appendectomy; Appendicitis; Clinical Trials as Topic; Female; Humans; Intestinal Perforation; Intestinal Pseudo-Obstruction; Male; Noxythiolin; Peritonitis; Surgical Wound Infection; Thiourea

Topics: Ampicillin; Antifungal Agents; Appendectomy; Appendicitis; Clinical Trials as Topic; Gangrene; Humans; Surgical Wound Infection; Thiourea

Peritoneal lavage resulted in a significant reduction in the duration of hospital stay in a retrospective series of 189 children with peritonitis secondary to perforation of the appendix. Antibiotic peritoneal lavage also resulted in a significant reduction in the number of children with septic and adhesive complications compared with antiseptic lavage and no lavage, mainly as a result of fewer wound infections. The overall incidence of residual intraperitoneal infection was low, and although differences in this respect were not significant, none of the children treated with antibiotic peritoneal lavage required reoperation for intraperitoneal sepsis.

Topics: Appendicitis; Child; Humans; Length of Stay; Noxythiolin; Peritonitis; Tetracycline; Therapeutic Irrigation; Thiourea