thiourea and Anemia--Hemolytic

Topics: Acetamides; Anemia, Hemolytic; Aniline Compounds; Animals; Clofazimine; Dapsone; Disease Models, Animal; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Leprosy; Methimazole; Mice; Mycobacterium leprae; Phenyl Ethers; Rifampin; Sulfonamides; Thiosemicarbazones; Thiourea

Activated neutrophils at effector/target ratios of 1:20 to 1:2,000 induced depletion of red blood cell (RBC)-reduced glutathione, increased membrane-bound hemoglobin and methemoglobin, and promoted immunoglobulin binding to the cell membrane. Superoxide dismutase/catalase ameliorated the decrease in reduced glutathione and the increase in methemoglobin and immunoglobulin binding. This is interpreted as evidence that activated neutrophils can alter the antigenic nature of the RBC membrane through generation of toxic oxygen radicals.

Topics: Anemia, Hemolytic; Animals; Cats; Dose-Response Relationship, Immunologic; Erythrocyte Membrane; Erythrocytes; Glutathione; Hemoglobins; Hydrogen Peroxide; Immunoglobulins; Inflammation; Methemoglobin; Neutrophils; Protease Inhibitors; Superoxides; Thiourea

Topics: Anemia, Hemolytic; Animals; Cell Membrane; Cell Membrane Permeability; Erythrocytes; Fatty Acids; Glycerolphosphate Dehydrogenase; Heinz Bodies; Humans; Lipids; Phenylhydrazines; Phospholipids; Proteins; Rabbits; Splenectomy; Thiourea

Topics: Anemia, Hemolytic; Aniline Compounds; Anti-Bacterial Agents; Dapsone; Drug Resistance, Microbial; Humans; Injections, Intramuscular; Leprosy; Mycobacterium leprae; Phenazines; Rifampin; Sulfonamides; Sulfones; Thioacetazone; Thiourea