thiourea and Adenocarcinoma--Follicular

thiourea has been researched along with Adenocarcinoma--Follicular* in 1 studies

Other Studies

1 other study(ies) available for thiourea and Adenocarcinoma--Follicular

ArticleYear
DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by chemicals carcinogenic to the rat thyroid.
    Mutation research, 2006, Oct-30, Volume: 609, Issue:2

    Five chemicals that are known to induce in rats thyroid follicular-cell adenomas and carcinomas were assayed for their ability to induce DNA damage and DNA repair synthesis in primary cultures of human thyroid cells. Significant dose-dependent increases in the frequency of DNA single-strand breaks and alkali-labile sites, as measured by the same Comet assay, were obtained after a 20-h exposure to the following subtoxic concentrations of the five test compounds: methimazole from 2.5 to 10mM; nitrobenzene, potassium bromate, N,N'-diethylthiourea and ethylenethiourea from 1.25 to 5mM. Under the same experimental conditions, DNA repair synthesis, as evaluated by quantitative autoradiography, was present in potassium bromate-exposed thyroid cells from all the three donors and in those from two of three donors with either nitrobenzene or ethylenethiourea, but did not match the criteria for a positive response in thyroid cells from any of the donors with methimazole and N,N'-diethylthiourea. Consistently with their ability to induce thyroid tumors, all the five test compounds, administered p.o. in rats in a single dose corresponding to 1/2 LD50, induced a statistically significant degree of DNA fragmentation in the thyroid. These findings suggest that the five test compounds might be carcinogenic to thyroid in humans.

    Topics: Adenocarcinoma, Follicular; Adenoma; Animals; Bromates; Carcinogens; Cells, Cultured; DNA Damage; DNA Fragmentation; DNA Repair; Ethylenethiourea; Humans; In Vitro Techniques; Kidney; Liver; Male; Methimazole; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Thiourea; Thyroid Gland; Thyroid Neoplasms

2006
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