thiouracil and Liver-Neoplasms

Topics: Bone Neoplasms; Brain Neoplasms; Gold Isotopes; Humans; Iodine Radioisotopes; Liver Neoplasms; Mercury Isotopes; Neoplasm Metastasis; Paraneoplastic Endocrine Syndromes; Radioisotopes; Radionuclide Imaging; Technetium; Thiouracil; Thyroid Gland; Thyroid Neoplasms; Thyrotropin

The condensation of 6-amino-2-thiouracil 1 with aromatic aldehydes afforded azomethine derivatives 3a,b. The formed azomethines underwent [4+2] cycloaddition with enaminones 4a-c and enaminonitrile 9 to form the corresponding condensed pyrimidines 8a-f and 11a,b, respectively. On the other hand, the interaction of 3a,b with acetylene derivatives 12a,b, 14 afforded the corresponding pyrido[2,3-d]pyrimidines 13a-d and 16a,b, respectively. The newly synthesized 2-azadiene 18 reacted with ortho-aminophenol and ortho-aminothiophenol 19a,b to yield the amidines 21a,b. The in vitro antimicrobial activity of some of the newly synthesized compounds was examined. All the tested compounds proved to be active as antibacterial and antifungal agents. Also the in vivo antitumor activity of compounds 8a, 11b, 13a,d, and 16b against lung (H460) and liver (HEPG2) carcinoma cells was examined. Compounds 8a, 16b showed moderate activity against lung carcinoma cell line (H460).

Topics: Antifungal Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Liver Neoplasms; Lung Neoplasms; Microbial Sensitivity Tests; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiouracil; Tumor Cells, Cultured

N-diethylnitrosamine (DEN) was simultaneously administered with diazepam (DZP) or thiouracil (TU) once weekly for life to gerbils (Meriones unguiculatus). Additional DZP or TU treatment increased significantly average survival time and inhibited the development of cholangiocarcinomas, although cholangiomas were still observed in these groups. Tumor type and incidence in the nasal cavities were not influenced by DZP or TU. However, in comparison to DEN alone tumor latencies were prolonged.

Topics: Adenoma, Bile Duct; Animals; Diazepam; Diethylnitrosamine; Gerbillinae; Liver; Liver Neoplasms; Thiouracil

Topics: Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; Escherichia coli; Genetic Code; Glutamates; Liver; Liver Neoplasms; Methylation; Nucleotides; RNA, Neoplasm; RNA, Transfer; Sulfhydryl Compounds; Templates, Genetic; Thiouracil; Tritium; Uridine; Yeasts

Topics: Aminohydrolases; Animals; Annelida; Carcinoma, Hepatocellular; Escherichia coli; Liver Neoplasms; Male; Mice; Neoplasms; Nucleotidases; Prostate; Rats; Ribonucleases; RNA, Transfer; Species Specificity; Thiouracil

Topics: Animals; Antineoplastic Agents; Benz(a)Anthracenes; Benzofurans; Carcinoma 256, Walker; Cortisone; Disulfiram; Ethionine; Hepatectomy; Liver Neoplasms; Liver Regeneration; Nikethamide; Phenylbutazone; Pyrimidines; Rats; Thalidomide; Thiouracil

Topics: Animals; Animals, Laboratory; Carcinoma, Hepatocellular; Liver Neoplasms; Mice; Mice, Inbred Strains; Thiouracil

Topics: Carcinogenesis; Humans; Liver Neoplasms; Neoplasms; Thiouracil; Uracil