thiouracil and Liver-Diseases

The effect of two levels each of methionine (0.0 and 0.07 percent), thiouracil (0.0 and 0.05 percent), dienestrol diacetate (0.0 and 0.007 percent), and thyroactive casein (0.0 and 0.0125 percent) on the performancy, organ changes, and liver composition in 640 pullets of two strains was studied in a 24 factorial arrangement of treatments. Egg production, egg characteristics, feed conversion, organ weights, and liver composition were parameters measured. Supplemental methionine increased the phosphorus content of liver fat in strain A, but other parameters in the two strains were mot affected by the increase in dietary methionine. The thiouracil increased weight grains, gram of fat per total liver, percent of liver fat, thyroid weight, and heart weight but decreased the phosphorus content of liver fat. Nine typical cases of fatty liver syndrome with large liver hematomas occurred in the thiouracil treated birds and one case occurred in an untreated pullet. Dienestrol diacetate did not affect egg production, egg characteristics, organ weights, and liver composition in the two strains. Thyroprotein decreased weight gain, abdominal fat, liver weight. liver fat, thyroid weight, and percent red cells, but decreased percent blood sports in eggs and adjusted weights of the kidney and heart in both strains.

Topics: Adipose Tissue; Animal Feed; Animals; Caseins; Chickens; Dienestrol; Eggs; Fatty Liver; Female; Hematoma; Hemorrhage; Iodoproteins; Lipid Metabolism; Liver; Liver Diseases; Methionine; Phenols; Phosphorus; Poultry Diseases; Syndrome; Thiouracil

Topics: Adrenalectomy; Androsterone; Anticholesteremic Agents; Butyrates; Castration; Cholesterol; Clofibrate; Glycerides; Hepatomegaly; Lipid Metabolism; Lipidoses; Lipids; Liver; Liver Diseases; Pharmacology; Rats; Research; Thiouracil; Thyroidectomy; Toxicology

Topics: Abdominal Injuries; Carbohydrate Metabolism; Carbon Tetrachloride; Glucuronates; Liver; Liver Diseases; Methylthiouracil; Thiouracil

Topics: Animals; Hypothyroidism; Liver; Liver Diseases; Liver Regeneration; Rats; Thiouracil; Thyroid Hormones; Triiodothyronine

Topics: Fatty Liver; Liver Diseases; Methylthiouracil; Thiouracil

Topics: Abdominal Injuries; Liver; Liver Diseases; Liver Function Tests; Thiouracil; Thiourea; Thyroid Gland; Thyrotoxicosis

Topics: Humans; Hyperplasia; Liver Diseases; Thiouracil; Thiourea; Thyroid Gland

Topics: Liver; Liver Diseases; Liver Regeneration; Thiouracil; Thiourea

Topics: Cytochromes c; Humans; Liver Diseases; Liver Regeneration; Thiouracil; Thyroidectomy