thiouracil and Hyperthyroidism

Topics: Adenoma; Carbimazole; Child; Eye Manifestations; Female; gamma-Globulins; Graves Disease; Hot Temperature; Humans; Hyperkinesis; Hyperthyroidism; Iodides; Iodine Isotopes; Long-Acting Thyroid Stimulator; Pregnancy; Sweating; Thiouracil; Thyroid Function Tests; Thyroidectomy; Thyroxine

Topics: Adult; Child; Chlordiazepoxide; Diazepam; Eye Manifestations; Female; Glucocorticoids; Graves Disease; Humans; Hyperthyroidism; Hypothyroidism; Imidazoles; Infant, Newborn; Iodine; Iodine Isotopes; Myxedema; Perchlorates; Potassium; Pregnancy; Pregnancy Complications; Propranolol; Reserpine; Thiouracil; Thyroid Crisis; Thyroidectomy

Topics: Animals; Autoradiography; Cerebellum; Cerebral Cortex; DNA; Female; Gestational Age; Hyperthyroidism; Hypothyroidism; Mitosis; Pregnancy; Rats; Thiouracil; Thymidine; Thyroxine; Time Factors; Tritium

Topics: Antithyroid Agents; Barbiturates; Carbimazole; Diiodotyrosine; Estrogens; Fluorides; Humans; Hyperthyroidism; Imidazoles; Iodine; Iodine Isotopes; Methylthiouracil; Perchlorates; Phenylacetates; Plant Extracts; Potassium; Propiophenones; Reserpine; Sodium; Sulfonamides; Thiazoles; Thiocyanates; Thiouracil; Tissue Extracts; Tyrosine; Vitamins

Topics: Basal Metabolism; Female; Fetal Death; Goiter; Humans; Hyperthyroidism; Infant; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methylthiouracil; Pregnancy; Pregnancy Complications; Propylthiouracil; Research; Thiouracil; Thyroid Function Tests; Thyrotropin; Thyroxine; Toxicology

Topics: Adenoma; Alpha-Globulins; Antibody Formation; Antigens; Autoantibodies; Autoimmune Diseases; Beta-Globulins; Blood Proteins; Child; Humans; Hyperthyroidism; Hypothyroidism; Organ Specificity; Serum Globulins; Species Specificity; Thiouracil; Thyroid Function Tests; Thyroid Hormones; Thyroid Neoplasms; Thyroiditis; Thyroiditis, Autoimmune; Thyrotropin; Triiodothyronine

Topics: Adult; Antithyroid Agents; Clinical Trials as Topic; Female; Follow-Up Studies; Goiter; Humans; Hyperthyroidism; Male; Middle Aged; Prognosis; Propylthiouracil; Thiouracil

The crystal structures of dimorphic benzylthiouracil, a drug against hyperthyroidism, have been redetermined and the atom coordinates of the two independent molecules of form I have been obtained for the first time. The dimorphism convincingly demonstrates the conformational versatility of the benzylthiouracil molecule. It has been established through calorimetric studies that the low-temperature form II transforms endothermically (Δ

Topics: Crystallization; Humans; Hyperthyroidism; Pharmaceutical Preparations; Pressure; Thiouracil

Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6-

Topics: Animals; Antithyroid Agents; Binding Sites; Disease Models, Animal; Hydrophobic and Hydrophilic Interactions; Hyperthyroidism; Lactoperoxidase; Models, Molecular; Rats; Structure-Activity Relationship; Thiouracil; Triiodothyronine; Uracil

The effect of the thyroid activity on the formation of lipid peroxidation and on liver and heart antioxidant enzyme activities was investigated in Wistar rats. Hypothyroidism and hyperthyroidism conditions were induced for five weeks by the administration of 0.05% benzythiouracile (BTU) and L-thyroxine sodium salt (0.0012%), in drinking water, respectively. No significant effect was observed on the rates of both lipid peroxidation and the vitamin E in hepatic and cardiac tissues of hypothyroidism rats compared to the controls, contrary to the hyperthyroidism rats, which expressed a pronounced increase. The increased glutathione peroxidase activity in rats suffering from hyperthyroidism was associated with a fall of the reduced glutathione in the homogenate and a marked increase in the glutathione reductase activity. An increase in superoxide dismutase and catalase activities was also recorded in hyperthyroidism. Our results explain the thyroid activity variation in relation to the lipid peroxidation and the tissular contents of the enzymatic and the non-enzymatic antioxidants. To conclude, our results show the occurrence of a state of oxidizing stress in relation to hyperthyroidism.

Topics: Animals; Body Weight; Catalase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hyperthyroidism; Hypothyroidism; Lipid Peroxidation; Liver; Male; Myocardium; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiouracil; Thyroid Gland; Thyroxine

Several cases of vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA) have been reported in patients treated with synthetic anti-thyroid drugs but only 2 cases have incriminated benzylthiouracil.. A 36 year-old woman, 3 years after treatment with benzylthiouracil, rapidly developed progressive kidney failure, related to a pauci-immune extra-capillary glomerular nephropathy and necrotic vasculitis lesions. The search for p-ANCA was positive with anti-myeloperoxidase specificity. She was treated with corticosteroids and 6 monthly intravenous pulses of cyclophosphamide substituted by azathioprine. Renal failure and proteinuria significantly improved. However the high level of p-ANCA.. ANCA vascularities are a rare but serious complication of treatment with synthetic thiouracile-type anti-thyroid drugs. The ANCA must be measured when confronted with a systemic manifestation during treatment.

Topics: Adrenal Cortex Hormones; Adult; Antibodies, Antinuclear; Female; Humans; Hyperthyroidism; Thiouracil; Uridine Phosphorylase; Vasculitis

This study determined the effects of thyroid hormone on the renal dopaminergic system. Surgical thyroidectomy (Tx) and treatment with 2-thiouracil (Thio) decreased renal cortex Na+/K+ ATPase activity and urinary volume. Tx also decreased urinary Na+ and urinary L-DOPA without changing urinary excretion of Dopamine (DA). Thio treatment decreased slightly urinary L-DOPA and Na+, but increased urinary excretion of DA. In both models of thyroid hormone deficiency, the ratio urinary DA/DOPA increased. Changes after Thio treatment were reversed after one month of drug withdrawal. Treatment with T3 via osmotic minipump increased Na+/K+ ATPase activity and urinary L-DOPA, did not change urinary DA, and increased the ratio DA/DOPA. To further analyze the effects of thyroid hormone deficiency, we administered selective DA1 (SCH-23390), DA2 (Sulpiride), and a non selective (Haloperidol) DA receptor antagonists to Thio treated and control animals. The DA1 antagonist decreased diuresis, natriuresis and urinary L-DOPA in control, but had no effect in Thio treated rats. Sulpiride had no effect in either group. The combination of SCH-23390 plus Sulpiride decreased urinary L-DOPA and urinary volume only in Thio treated animals. Haloperidol decreased urinary volume in Thio treated animals, but had no effect in controls. Our findings suggest that renal DA synthesis is to some extent dependent on thyroid hormone levels, and that the response of DA receptors is altered by thyroid hormone deficiency, indicating a role of this hormone in the regulation of the renal dopaminergic system.

Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antithyroid Agents; Benzazepines; Catechols; Dihydroxyphenylalanine; Dopamine; Dopamine Antagonists; Haloperidol; Hyperthyroidism; Hypothyroidism; Kidney; Male; Rats; Receptors, Dopamine D1; Sodium-Potassium-Exchanging ATPase; Thiouracil; Thyroid Hormones; Thyroidectomy

Changes in thyroid status affect metabolism not only directly, but influence it also by alterations in insulin secretion and action. Despite several investigations, these effects are, however, poorly characterised or even controversial. The aim of the studies was to investigate the effect of hyperthyreosis (HT) and hypothyreosis (HPT) on insulin binding by rat liver membranes. Some metabolic parameters reflecting insulin and thyroid hormones action were also determined. HT and HPT were developed by daily administration for 3 weeks of thyroxine (T (4) ) and thiouracil (TU), respectively. Experimental hyperthyreosis and hypothyreosis caused deep changes in metabolism. The greatest alterations were observed in body and thyroid glands weight, blood triiodothyronine (T (3) ), T (4), glucose, and insulin levels, liver glycogen amount and number of insulin receptors. HT reflected in rats in slower rate of growth and in smaller thyroid glands weight. In comparison to controls, T (4) concentration in HT was almost doubled and it was reduced by about 30% in HPT. Also, T(3), insulin and glucose levels in HT were heightened. Simultaneously, binding of insulin to liver membranes was elevated in HT and reduced in HPT. In HT the number of high affinity insulin receptors (HAIRs) and low affinity insulin receptors (LAIRs) was increased, whereas in HPT the amount of HAIRs was diminished. HT caused a drastic reduction of glycogen concentration in liver, but no changes were observed for muscle glycogen. Considering lipid metabolism, only free fatty acids (FFA) level in blood was changed (in HPT), but no differences were observed in serum concentration of triglycerides and cholesterol. Several metabolic changes observed in HT and HPT seem to be the dire ct consequence of alterations of thyroid hormone concentrations. These disturbances, together with the direct effect of HT or HPT on insulin secretion, binding and action lead, in turn, to changes in the other metabolic parameters. As a result of these disturbances the adaptive mechanisms appear. One of them is change in the number of insulin membrane receptors taking place even against the well known "down-regulation" theory.

Topics: Animals; Antithyroid Agents; Cholesterol; Fatty Acids, Nonesterified; Glucose; Glycogen; Hyperthyroidism; Hypothyroidism; Insulin; Liver; Male; Protein Binding; Rats; Rats, Wistar; Receptor, Insulin; Thiouracil; Thyroxine; Triglycerides

Thyrostatic treatment of pregnant women with Graves' disease is a special problem. Observation of 46 pregnancies of 35 women suffering from Graves' disease has been summarized. The outcome was successful in 45 cases. Methimazole and propylthiouracil was administered to the patients without thyroxine. Therapy was needed for the two thirds of the mothers. At the end of the second trimester the thyrostatic agent could have been withdrawn in the 77% of the cases. Antithyroid treatment administered in low dose at the time of conception did not affect the outcome. Premature delivery rate and the number of neonates with low weight did not increased. Transient hyperthyrotropinaemia was observed in one case. Likewise, one infant suffered from neonatal thyrotoxicosis. 37% of the mothers had postpartal recurrence of hyperthyroidism.. the free thyroxin level monitoring is essential during thyrostatic treatment. Thyrotropin receptor antibody investigation, having predictive value for neonatal thyrotoxicosis, should be done, too. Postpartal thyroid control is necessary for elucidate a hyperthyroid relapse, the rate of which was almost 40%.

Topics: Adult; Antithyroid Agents; Female; Graves Disease; Humans; Hyperthyroidism; Infant, Newborn; Maternal-Fetal Exchange; Methimazole; Predictive Value of Tests; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prognosis; Recurrence; Thiouracil; Thyrotoxicosis; Thyroxine; Treatment Outcome

Sixteen cases of pediatric hyperthyroidism treated by antithyroid drugs are reported. First-line treatment with carbimazole in a mean dose of 19 mg/m2 initially and 7 mg/m2 after one year ensured control of the disease within 6 weeks. Mean follow-up was 4 years. Only two children were able to discontinue the drug, after 9.1 years and 4.6 years. Two other patients had thyroidectomy, after 6.7 years and 3.4 years. The main disadvantages of antithyroid drugs are the need for prolonged treatment and the risk of recurrence. An attempt at treatment discontinuation is warranted in patients with good disease control of 2 to 3 years duration, goiter size reduction, improved exophthalmos, and decreased anti-TSH receptor antibodies.

Topics: Autoantibodies; Autoimmune Diseases; Body Mass Index; Carbimazole; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Hyperthyroidism; Infant; Male; Recurrence; Thiouracil; Thyroglobulin; Thyroid Function Tests; Thyroidectomy

This work tests the notion that the effect of thyroid hormone on orbital and ocular tissues is mediated through its action on their lysosomal enzymes. Hyperthyroidism was produced in guinea pigs by thyroxin and TSH; hypothyroidism was induced by thiouracil. After treatment for 10 to 21 days, several ocular and orbital tissues were taken for histological, morphometrical, and histochemical examinations. High acid phosphatase activity was demonstrated in extraocular muscles, optic nerve and the retinal pigment epithelium of thyroxine- and TSH-treated animals. The findings fit the notion that the effects of thyroid hormones are mediated through lysosomes also in ocular and orbital tissues.

Topics: Adipose Tissue; Animals; Eye; Female; Guinea Pigs; Hyperthyroidism; Hypothyroidism; Lysosomes; Oculomotor Muscles; Retina; Thiouracil; Thyrotropin; Thyroxine

Ten hyperthyroid patients were assessed for muscle strength before and after a period of medical treatment that averaged 12 months. The subjects did not change their habitual level of physical activity between the two test occasions. Maximal voluntary isokinetic knee extensor muscle strength was determined during various concentric, eccentric and isometric conditions. Average increases in strength from before to termination of treatment ranged from 25 to 41% for the concentric and isometric tests (P less than 0.01, n = 10), and from 19 to 35% for the eccentric tests (P less than 0.01, n = 6). The present study demonstrates that medical treatment of hyperthyroid patients results in a marked increase in muscle strength.

Topics: Adult; Analysis of Variance; Body Weight; Female; Humans; Hyperthyroidism; Male; Methimazole; Muscles; Propranolol; Thiouracil

Seven hyperthyroid patients were studied by repeated muscle biopsies (vastus lateralis) before and after a period of medical treatment which averaged 10 months. The biopsies were analysed with regard to fibre-type composition, fibre area, capillary density, glycogen content and enzyme activities representing the glycolytic capacity (hexokinase, 6-phosphofructokinase), oxidative capacity (oxoglutarate dehydrogenase, citrate synthase) and Ca2+- and Mg2+-stimulated ATPase in muscle. In the pretreatment biopsy (hyperthyroid state), there was a significantly lower proportion of type I fibres (30% vs. 41%), a higher capillary density (23%), lower glycogen content (33%), and higher hexokinase activity (32%) compared with the post-treatment biopsy. No significant changes in the activity of the remaining enzymes were observed. The present study indicates that hyperthyroidism induces a transformation from type I to type II fibres in human skeletal muscle. The increase in hexokinase activity probably reflects a higher glucose utilization by skeletal muscle in order to compensate partially for the reduced glycogen content.

Topics: Adult; Biopsy; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Citrate (si)-Synthase; Female; Glycogen; Hexokinase; Humans; Hyperthyroidism; Ketoglutarate Dehydrogenase Complex; Male; Methimazole; Middle Aged; Muscles; Phosphofructokinase-1; Thiouracil

Long-term (35 days) effects of thyroid hormone on the number of myocardial beta-adrenergic receptors and the c-AMP concentration were studied in the rat. The ventricles from triiodothyronine-administered rats (T3 rats) showed an increase in the number of beta-receptors compared to controls (54.3 +/- 3.1 vs 39.3 +/- 1.8 fmole of [125I]-iodohydroxybenzylpindolol (IHYP) binding sites/mg protein p less than 0.001) on the 35th day. Conversely, the ventricles from thiouracil-administered rats (TU rats) showed a decrease in the number of beta-receptors compared to controls (31.4 +/- 1.6 vs. 38.4 +/- 2.6 fmole/mg protein, p less than 0.05). The equilibrium dissociation constants (Kd) for the interaction of receptors with IHYP did not differ significantly (0.10 to 0.15 nM). The myocardial concentration of cyclic AMP was not significantly different (T3 rats, 1.09 +/- 0.09 nM/g wet weight tissue; T3 controls, 1.12 +/- 0.07; TU rats, 1.13 +/- 0.07; TU controls, 1.16 +/- 0.12) on the 35th day. On serial effects of triiodothyronine from the first to the 35th day, the number of beta-receptors of T3 rats increased significantly on the 24th and the 35th day, but the c-AMP concentration was not significantly different from that in control rats. These results demonstrated that thyroid hormone affects the number of myocardial beta-receptors in rats, and suggested a different mechanism of action of thyroid hormone on the myocardium from that of catecholamines.

Topics: Animals; Body Weight; Cyclic AMP; Hyperthyroidism; Hypothyroidism; Male; Myocardium; Organ Size; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Thiouracil; Triiodothyronine

Topics: Animals; History, 20th Century; Humans; Hyperthyroidism; Thiouracil; Thiourea

Topics: History, 20th Century; Humans; Hyperthyroidism; Thiouracil; Thiourea; United States

Topics: Female; Humans; Hyperthyroidism; Iodides; Pregnancy; Pregnancy Complications; Thiouracil

Topics: Animals; Folic Acid; Histidine; Hyperthyroidism; Liver; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Nutritional Physiological Phenomena; Thiouracil; Thyroid Gland; Thyroidectomy; Thyroxine; Tissue Extracts; Vitamin B 12

Topics: Female; Humans; Hyperthyroidism; Pregnancy; Pregnancy Complications; Thiouracil

Topics: Animals; Cadmium; Hyperthyroidism; Hypothyroidism; Kidney; Liver; Male; Radioisotopes; Rats; Thiouracil; Thyroxine; Time Factors

Topics: Adrenergic beta-Antagonists; Antithyroid Agents; Carbimazole; Humans; Hyperthyroidism; Iodine Radioisotopes; Lithium; Potassium Iodide; Thiouracil; Thyroidectomy

Topics: Adolescent; Asthma; Dose-Response Relationship, Drug; Humans; Hyperthyroidism; Male; Physical Exertion; Thiouracil

The possibilities of the treatment of hyperthyroidism are mentioned, in which cases the author especially deals with the medicamentous therapy, taking into consideration the different chemical groups (imidazol derivations, thiourazil derivations, perchlorates) and their therapeutic mechanisms. The indications and contraindications of this treatment and the possible side effects are compiled in form of a table. The in-vitro-parameters which are necessary for the observation of the course are estimated in their significance. The author deals with the problems of the additional treatment. Taking into consideration indications and contraindications as well as controls of the course of functional parameters the medicamentous therapy concerned is a treatment with a good prognosis. It is promising particularly in such cases, when suitable parameters are used for the solution of the question concerning the end of the therapy. For this purpose nowadays two tests are at our disposal: 1. modified Alexander's test (radioiodine-test and suppression test under thyreostatic therapy) and 2. TRH-test with radioimmunological determination of TSH. The treatment should be carried out in adequate endocrinological dispensaries, as there are certain risks in not optimal therapy.

Topics: Conjunctivitis; Drug Eruptions; Fever; Humans; Hyperthyroidism; Methimazole; Nausea; Perchlorates; Thiouracil

The TRH-degrading activity of rat serum in vitro is five times more potent than that of human serum. In rats, it is significantly reduced in hypothyroidism (thiouracil-induced) and significantly increased in hyperthyroidism (T3 or T4-induced). This suggests a possible role in the regulation of adenohypophysial-thyroid function which is probably, in turn, dependent on thyroid hormone, rather than TSH, levels.

Topics: Animals; Cold Temperature; Enzyme Activation; Female; Hyperthyroidism; Hypothalamus; Hypothyroidism; Male; Peptide Hydrolases; Pituitary Gland, Anterior; Rats; Thiouracil; Thyroid Gland; Thyroid Hormones; Thyrotropin-Releasing Hormone

An infant, whose mother was treated for thyrotoxicosis during pregnancy, appeared normal at birth, but laboratory data were indicative of hypothyroidism. On the sixth day of life the infant had clinical and laboratory evidence of hyperthyroidism. A plan of management is proposed for infants born to thyrotoxic mothers.

Topics: Adult; Female; Fetal Blood; Humans; Hyperthyroidism; Hypothyroidism; Infant, Newborn; Infant, Newborn, Diseases; Iodine; Long-Acting Thyroid Stimulator; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Protein Binding; Thiouracil; Thyroid Function Tests; Thyrotropin; Thyroxine

Effect of 1-methyl-2-mercaptoimidazole (MMI) on the serum triiodothyronine (T3) and thyroxine (T4) was studied in six patients with hyperthyroidism. From 30 to 60 mg of MMI per day were administered to the patients orally. Serum T3 was measured by radioimmunoassay and T4 by radioimmunoassay of Tetrasorb Kit (Abbott Lab.). Serum T4/T3 ratios in these patients were low initially, but increased to normal range in two cases immediately after the administration of MMI. But they were unchanged at first in the other four cases. When high serum T3 values decreased abruptly to normal at a later course of medication, the serum T4/T3 ratios increased to normal range in almost all cases. Even though the serum T4/T3 ratio became normal, serum T3 and T4 values remained high in some cases. Elevated serum T4 values in all cases decreased to normal faster than serum T3 with the administration of MMI. When MMI was administered to the patents concinuously, the T4/T3 ratios, once increased to normal, then decreased again gradually in five cases. And serum T3 which decreased to normal sometimes gave high values. After the discontinuation of MMI, serum T3 increased over the normal range more rapidly than did T4.

Topics: Adult; Female; Humans; Hyperthyroidism; Male; Methimazole; Middle Aged; Radioimmunoassay; Thiouracil; Thyroxine; Time Factors; Triiodothyronine

Topics: Female; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Propranolol; Thiouracil; Thyroidectomy

Topics: Antithyroid Agents; Chemistry; Contraceptives, Oral; Female; Goiter; History, 19th Century; History, 20th Century; Humans; Hyperthyroidism; Hypothyroidism; Imidazoles; Iodine Radioisotopes; Lithium; Perchlorates; Pregnancy; Thiouracil; Thyroid (USP); Thyroid Diseases; Thyroid Hormones; Thyroid Neoplasms; Thyroxine; Triiodothyronine

Topics: Aging; Animals; Half-Life; Hyperthyroidism; Hypothyroidism; Male; Monoamine Oxidase; Myocardium; Organ Size; Pargyline; Rats; Thiouracil; Thyroid Hormones; Thyroxine

Topics: Adult; Aged; Antithyroid Agents; Chemical Phenomena; Chemistry; Female; Humans; Hyperthyroidism; Imidazoles; Male; Methylthiouracil; Perchlorates; Propylthiouracil; Sympatholytics; Thiouracil; Thyroid Hormones; Thyronines

Topics: Adolescent; Adult; Age Factors; Antithyroid Agents; Carbimazole; Child; Goiter; Humans; Hyperthyroidism; Hypothyroidism; Iodine; Iodine Isotopes; Propranolol; Thiouracil; Thyroid Diseases; Thyroxine; Triiodothyronine

Topics: Angina Pectoris; Animals; Epinephrine; Glycols; Hyperthyroidism; Hypothyroidism; Lethal Dose 50; Male; Nitrates; Nitroglycerin; Rats; Thiouracil; Thyroid Hormones; Thyroxine; Triiodothyronine

Topics: Aged; Arthritis, Rheumatoid; Autopsy; Diabetes Complications; Female; Goiter; Goiter, Nodular; Heart Failure; Humans; Hyperthyroidism; Iodine Isotopes; Thiouracil; Thyroid Crisis; Thyroid Gland

Topics: Acclimatization; Altitude; Animals; Female; Goiter; Hyperthyroidism; Hypothyroidism; Iodine; Rats; Rats, Inbred Strains; Thiouracil; Thyroid Function Tests; Thyroid Gland; Thyroidectomy; Thyrotropin; Thyroxine

Topics: Animals; Benzyl Compounds; Drug Synergism; Gallamine Triethiodide; Germ-Free Life; Hyperthyroidism; Hypothyroidism; Male; Neuromuscular Nondepolarizing Agents; Rats; Succinylcholine; Thiouracil; Thyroid Gland; Thyroidectomy; Thyrotropin; Tissue Extracts; Tubocurarine

Topics: Antihypertensive Agents; Humans; Hyperthyroidism; Perchlorates; Plant Extracts; Thiouracil

Topics: Adult; Humans; Hyperthyroidism; Male; Thiouracil; Thyroid Crisis

Topics: Adult; Antithyroid Agents; Child; Exophthalmos; Female; Humans; Hyperthyroidism; Imidazoles; Iodides; Iodine; Perchlorates; Pregnancy; Pregnancy Complications; Thiouracil

Topics: Animals; Body Weight; Cardiac Output; Heart Rate; Hyperthyroidism; Hypothyroidism; Male; Organ Size; Rats; Temperature; Thiouracil; Thyroxine

Topics: Animals; Cytoplasm; Ethanol; Hyperthyroidism; Hypothyroidism; Liver; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats; Sorbitol; Thiouracil; Triiodothyronine

Topics: Adolescent; Age Factors; Child; Child, Preschool; Deficiency Diseases; Disease Reservoirs; Female; Goiter; Humans; Hyperthyroidism; Imidazoles; Iodine; Male; Sex Factors; Thiouracil; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyroxine; Tissue Extracts; Triiodothyronine

Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Congenital Hypothyroidism; Cushing Syndrome; Female; Glucocorticoids; Goiter; Humans; Hydrocortisone; Hyperparathyroidism; Hyperthyroidism; Hypocalcemia; Hypoparathyroidism; Infant, Newborn; Iodine; Maternal-Fetal Exchange; Parathyroid Diseases; Pregnancy; Thiouracil; Thyroid Hormones

Topics: Adenoma; Graves Disease; Humans; Hyperthyroidism; Iodine; Iodine Isotopes; Perchlorates; Thiouracil; Thyroglobulin; Thyroid Neoplasms; Thyroidectomy

Topics: Aging; Animals; Animals, Newborn; Brain; Cytoplasm; Glycerolphosphate Dehydrogenase; Hyperthyroidism; Hypothyroidism; Liver; Malate Dehydrogenase; Mitochondria; Mitochondria, Liver; Rats; Thiouracil; Thyroxine; Tissue Extracts

Topics: Chemical and Drug Induced Liver Injury; Female; Glucocorticoids; Hepatitis A; Humans; Hyperthyroidism; Imidazoles; Middle Aged; Thiouracil

Topics: Hyperthyroidism; Iodine Isotopes; Oklahoma; Thiouracil; United States

Topics: Adult; Auscultation; Female; Humans; Hyperthyroidism; Male; Methods; Potassium Iodide; Quinine; Thiouracil; Thyroid Gland

Topics: Aged; Exophthalmos; Graves Disease; Humans; Hyperthyroidism; Male; Osteoarthropathy, Secondary Hypertrophic; Thiouracil

Topics: Adolescent; Adult; Antithyroid Agents; Blood Cell Count; Diagnosis, Differential; Diagnostic Errors; Female; Goiter; Heart Auscultation; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Methylthiouracil; Myxedema; Nervous System Diseases; Neurotic Disorders; Propylthiouracil; Radioisotope Dilution Technique; Thiazoles; Thiouracil; Thiourea; Thyrotropin

Topics: Adolescent; Adult; Antithyroid Agents; Female; Follow-Up Studies; Humans; Hyperthyroidism; Hypothyroidism; Iodine Isotopes; Male; Middle Aged; Reflex, Stretch; Thiouracil; Thyroid Function Tests

Topics: Adenoma; Antithyroid Agents; Graves Disease; Humans; Hyperthyroidism; Imidazoles; Iodine; Perchlorates; Potassium; Radiography; Radionuclide Imaging; Sulfhydryl Compounds; Thiouracil; Thyroid Neoplasms; Thyroidectomy

Topics: Animals; Blood Protein Electrophoresis; Body Weight; Dental Caries Susceptibility; Female; Food; Hyperthyroidism; Hypothyroidism; Male; Organ Size; Protein Biosynthesis; Rats; Saliva; Submandibular Gland; Thiouracil; Thyroid Gland

Topics: Adult; Female; Humans; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Thiouracil

Topics: Animals; Ascariasis; Ascaris; Ecology; Female; Hyperthyroidism; Hypothyroidism; Male; Mice; Thiouracil; Thyroxine

Topics: Adult; Animals; Electrocardiography; Electroencephalography; Electromyography; Eye Movements; Female; Hippocampus; Humans; Hyperthyroidism; Hypothalamus; Hypothyroidism; Male; Middle Aged; Rats; Respiration; Sleep; Thiouracil; Thyroxine

Topics: Animals; Biological Assay; Chickens; Chorionic Gonadotropin; Follicle Stimulating Hormone; Gonadotropins; Humans; Hyperthyroidism; Luteinizing Hormone; Male; Pharmacology; Phosphorus; Phosphorus Isotopes; Poultry; Radiometry; Research; Testis; Thiouracil; Thyroxine

Topics: Antithyroid Agents; Humans; Hyperthyroidism; Iodine Isotopes; Thiouracil

Topics: Humans; Hyperthyroidism; Iodine Isotopes; Thiouracil; Thyroidectomy

Topics: Adrenal Glands; Butter; Caseins; Cholesterol; Cottonseed Oil; Dietary Fats; Hyperthyroidism; Hypothyroidism; Liver; Metabolism; Rats; Research; Thiouracil; Thyroid Gland

Topics: Carcinoma; Endometriosis; Endometritis; Female; Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine Isotopes; Myxedema; Neoplasms; Ovarian Neoplasms; Salpingitis; Thiouracil; Thyroid Diseases; Thyroidectomy; Tuberculosis; Tuberculosis, Female Genital; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: Adolescent; Down Syndrome; Humans; Hyperthyroidism; Leukocytes; Thiouracil; Trisomy

Topics: Diagnosis; Female; Humans; Hyperthyroidism; Hypothyroidism; Pregnancy; Pregnancy Complications; Thiouracil; Thyroid Diseases

Topics: Antithyroid Agents; Humans; Hyperthyroidism; Imidazoles; Iodides; Iodine; Iodine Isotopes; Perchlorates; Radiotherapy; Thiouracil

Topics: Autoradiography; Electrophoresis; Goiter; Humans; Hyperthyroidism; Iodates; Iodides; Iodine; Iodine Isotopes; Methylthiouracil; Proteins; Thiouracil; Thyroglobulin; Thyroid Gland

Topics: Aging; Antithyroid Agents; Exophthalmos; Goiter; Humans; Hyperthyroidism; Iodides; Iodine; Iodine Isotopes; Postoperative Complications; Thiocyanates; Thiouracil; Thyroidectomy

Topics: Animals; Colloids; Cortisone; Cricetinae; Goiter; Hyperplasia; Hyperthyroidism; Iodine; Pharmacology; Research; Sulfadiazine; Thiocyanates; Thiouracil; Thyroiditis; Triiodothyronine

Topics: Antithyroid Agents; Humans; Hyperthyroidism; Imidazoles; Iodine Isotopes; Thiouracil; Thyroidectomy

Topics: Antithyroid Agents; Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Perchlorates; Radiotherapy; Thiouracil; Thiourea; Thyroidectomy

Topics: Acromegaly; Clinical Laboratory Techniques; Digitalis Glycosides; Growth Hormone; Hemagglutination Inhibition Tests; Human Growth Hormone; Humans; Hyperthyroidism; Hypopituitarism; Hypothyroidism; Thiouracil; Thyroid Hormones

Topics: Combined Modality Therapy; Hyperthyroidism; Manipulation, Osteopathic; Perchlorates; Propylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Antineoplastic Agents, Hormonal; Antithyroid Agents; Humans; Hyperthyroidism; Hypothyroidism; Iodine; Iodine Radioisotopes; Radioisotopes; Thiouracil

Topics: Humans; Hyperthyroidism; Hypothyroidism; Iodine; Iodine Radioisotopes; Propylthiouracil; Radioisotopes; Thiouracil; Thyroxine

Topics: Humans; Hyperthyroidism; Thiouracil

Topics: Humans; Hyperthyroidism; Imidazoles; Iodides; Iodine; Iodine Isotopes; Potassium; Reserpine; Thiouracil

Topics: Humans; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Reserpine; Thiouracil; Thyrotoxicosis

Topics: Combined Modality Therapy; Goiter; Hyperthyroidism; Iodine; Iodine Radioisotopes; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Iodine; Iodine Radioisotopes; Methylthiouracil; Radioisotopes; Thiouracil

Topics: Antineoplastic Agents, Hormonal; Antithyroid Agents; Carbimazole; Humans; Hyperthyroidism; Methylthiouracil; Perchlorates; Potassium Compounds; Thiouracil; Thyrotoxicosis

Topics: Graves Disease; Humans; Hyperthyroidism; Immunologic Tests; Iodides; Iodine; Methylthiouracil; Thiouracil

Topics: Antithyroid Agents; Hyperthyroidism; Thiouracil

Topics: Antithyroid Agents; Hyperthyroidism; Thiouracil

Topics: Hydroxypropiophenone; Hyperthyroidism; Methionine; Pituitary Hormones, Anterior; Thiouracil

Topics: Cardiovascular Agents; Hydroxypropiophenone; Hyperthyroidism; Muscle Relaxants, Central; Pituitary Gland; Thiouracil

Topics: Agranulocytosis; Heart Failure; Hyperthyroidism; Propylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Cardiovascular Agents; Hydroxypropiophenone; Hyperthyroidism; Muscle Relaxants, Central; Pituitary Diseases; Pituitary Gland; Thiouracil

Topics: Animals; Bromides; Bromine; Guinea Pigs; Hyperthyroidism; Methylthiouracil; Rats; Thiouracil; Thyroid Gland; Viscera

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Child; Disease; Diseases in Twins; Female; Goiter; Humans; Hyperthyroidism; Infant; Pregnancy; Propylthiouracil; Thiouracil; Twins

Topics: Child; Female; Goiter; Humans; Hyperthyroidism; Infant; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Thiouracil; Thyroid Diseases

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyroxine

Topics: Hyperthyroidism; Pregnancy; Thiouracil; Thyrotoxicosis

Topics: Goiter; Humans; Hyperthyroidism; Methylthiouracil; Syndrome; Thiouracil

Topics: Goiter; Hyperkinesis; Hyperthyroidism; Hypothalamus; Methylthiouracil; Neurosecretion; Pharmaceutical Preparations; Thiouracil

Topics: Child; Humans; Hyperthyroidism; Infant; Thiouracil

Topics: Cardiovascular Diseases; Humans; Hyperthyroidism; Tachycardia; Thiouracil

Topics: 17-Ketosteroids; Body Fluids; Graves Disease; Hyperthyroidism; Methylthiouracil; Steroids; Thiouracil; Urine

Topics: Female; Fetal Diseases; Fetus; Humans; Hyperthyroidism; Pregnancy; Pregnancy Complications; Pyruvates; Thiouracil

Topics: Animals; Estradiol; Estrogens; Goiter; Hyperthyroidism; Rats; Thiouracil

Topics: Antithyroid Agents; Female; Fetus; Humans; Hyperthyroidism; Pregnancy; Thiouracil

Topics: Blood Transfusion; Cortisone; Hemostatics; Hyperthyroidism; Hypoprothrombinemias; Propylthiouracil; Prothrombin; Thiouracil; Vitamin K

Topics: Hyperthyroidism; Methylthiouracil; Radiotherapy; Thiouracil; X-Ray Therapy; X-Rays

Topics: Hyperthyroidism; Iodides; Iodine; Phosphoric Acids; Thiouracil; Thyroid Function Tests; Thyroid Gland

Topics: Agranulocytosis; Anemia; Diaphragm; Hernia; Hernia, Diaphragmatic; Hyperthyroidism; Spinal Cord; Spinal Cord Diseases; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Pregnancy; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Neoplasms; Thiazoles; Thiouracil

Topics: Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Iodine; Iodine Radioisotopes; Propylthiouracil; Radioisotopes; Thiouracil; Thyroid Gland; Viscera

Topics: Humans; Hyperthyroidism; Iodine; Kinetics; Propylthiouracil; Thiouracil; Thyroid Gland; Viscera

Topics: Hyperthyroidism; Perchlorates; Potassium; Potassium Compounds; Thiouracil; Thyrotoxicosis

Topics: Diabetes Complications; Diabetes Mellitus; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Syndrome; Thiouracil

Topics: Antithyroid Agents; Hyperthyroidism; Methimazole; Thiouracil

Topics: Abortion, Induced; Female; Fetus; Humans; Hyperthyroidism; Pregnancy; Pregnancy Complications; Thiouracil

Topics: Goiter; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Animals; Growth; Hyperthyroidism; Liver; Rats; Thiouracil

Topics: Graves Disease; Humans; Hyperthyroidism; Methylthiouracil; Thiouracil; Tuberculosis; Tuberculosis, Miliary

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Crisis

Topics: Humans; Hyperthyroidism; Myasthenia Gravis; Neostigmine; Thiouracil

Topics: Angina Pectoris; Humans; Hyperthyroidism; Thiouracil

Topics: Humans; Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Lymphocytes; Thiouracil; Thyrotoxicosis

Topics: Antithyroid Agents; Humans; Hyperthyroidism; Radiotherapy; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Female; Fetus; Humans; Hyperthyroidism; Pregnancy; Thiouracil

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Humans; Hyperthyroidism; Iodides; Kinetics; Physics; Propylthiouracil; Thiouracil; Thyroid Gland; Viscera

Topics: Child; Female; Goiter; Humans; Hyperthyroidism; Infant; Infant, Newborn; Pregnancy; Thiouracil

Topics: Hyperthyroidism; Insulin; Insulin Resistance; Insulins; Thiouracil

Topics: Aged; Asthma; Humans; Hyperthyroidism; Thiouracil

Topics: Graves Disease; Humans; Hyperthyroidism; Neoplasms; Thiouracil; Thyroid Gland; Thyroid Neoplasms

Topics: Adrenal Cortex; Ascorbic Acid; Guinea Pigs; Hyperthyroidism; Scurvy; Thiouracil; Thyroxine; Vitamins

Topics: Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyrotoxicosis; Thyroxine

Topics: Hyperthyroidism; Potassium Iodide; Sodium; Thiouracil

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Biometry; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Agranulocytosis; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Female; Fetus; Humans; Hyperthyroidism; Pregnancy; Thiouracil

Topics: Female; Humans; Hyperthyroidism; Hypothyroidism; Infant; Infant, Newborn; Pregnancy; Thiouracil

Topics: Goiter; Humans; Hyperthyroidism; Iodine; Iodine Radioisotopes; Myxedema; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Propylthiouracil; Smell; Taste; Thiouracil

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Endocrine System Diseases; Hyperthyroidism; Methylthiouracil; Musculoskeletal Diseases; Thiouracil

Topics: Hyperthyroidism; Thiouracil; Thyroxine

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Child; Disease Management; Humans; Hyperthyroidism; Imidazoles; Infant; Parathyroid Glands; Thiouracil; Thyroid Gland

Topics: Female; Humans; Hyperthyroidism; Pregnancy; Thiouracil

Topics: Humans; Hyperthyroidism; Preoperative Care; Propylthiouracil; Thiouracil; Thyroidectomy

Topics: Biomedical Research; Hyperthyroidism; Thiouracil

Topics: Goiter; Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Follow-Up Studies; Graves Disease; Humans; Hyperthyroidism; Patient Selection; Propylthiouracil; Thiouracil

Topics: Adrenocorticotropic Hormone; Graves Disease; Hyperthyroidism; Iodides; Iodine; Thiouracil

Topics: Blood; Hyperthyroidism; Iodides; Iodine; Thiouracil

Topics: Hyperthyroidism; Iodine; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Humans; Hyperthyroidism; Iodine; Iodine Radioisotopes; Language; Propylthiouracil; Thiouracil; Thyroid Gland; Viscera

Topics: Antithyroid Agents; Hyperthyroidism; Thiouracil

Topics: Cholelithiasis; Humans; Hyperthyroidism; Jaundice; Lithiasis; Syndrome; Thiouracil

Topics: Hyperthyroidism; Neuritis; Thiouracil

Topics: Goiter; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil

Topics: Exophthalmos; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Blood Proteins; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Cardiomyopathies; Electrocardiography; Heart; Hyperthyroidism; Thiouracil

Topics: Graves Disease; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Blood Cells; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Agranulocytosis; Chemical and Drug Induced Liver Injury; Death; Humans; Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Goiter; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Humans; Hyperthyroidism; Long-Term Care; Propylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil

Topics: Blood Proteins; Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Thiouracil

Topics: Bone Marrow; Eosinophils; Hyperthyroidism; Methylthiouracil; Propylthiouracil; Thiouracil

Topics: Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Thiouracil

Topics: Edema; Graves Disease; Hyperthyroidism; Myxedema; Propylthiouracil; Thiouracil

Topics: Antithyroid Agents; Humans; Hyperthyroidism; Methimazole; Propylthiouracil; Thiouracil

Topics: Antineoplastic Agents, Hormonal; Hyperthyroidism; Thiouracil

Topics: Basal Metabolism; Humans; Hyperthyroidism; Thiosemicarbazones; Thiouracil; Tuberculosis; Tuberculosis, Pulmonary

Topics: Humans; Hyperthyroidism; Iodides; Iodine; Mental Disorders; Substance-Related Disorders; Thiouracil

Topics: Agranulocytosis; Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Mental Disorders; Substance-Related Disorders; Thiouracil

The preoperative use of antithyroid drugs is mandatory if surgical treatment of complicated hyperthyroidism is contemplated. Six months to a year may be required for suitable preparation. The long-term use of antithyroid drugs is less effective for the "cure" of hyperthyroidism than is operation or the use of radioactive iodine. Propyl and methyl thiouracil are the antithyroid drugs of choice. Either of these thiouracil derivatives is capable of producing leukopenia. The antithyroid drugs exert no favorable effect on exophthalmos. The antithyroid drugs are suitable for the control of hyperthyroidism during pregnancy. The patient probably should not be kept hypothyroid during pregnancy but rather in a state of mild hyperthyroidism.

Topics: Antithyroid Agents; Exophthalmos; Female; Humans; Hyperthyroidism; Hypothyroidism; Pregnancy; Thiouracil

Topics: Hyperthyroidism; Iodides; Iodine; Iodine Compounds; Radioactivity; Thiouracil

Topics: Calcium; Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Thiouracil

Topics: Goiter; Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Thiouracil

Topics: Humans; Hyperthyroidism; Iodine; Propylthiouracil; Radioisotopes; Thiouracil; Thyroidectomy

Topics: Graves Disease; Humans; Hyperthyroidism; Propylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Minnesota; Thiouracil

Topics: Humans; Hypertension; Hyperthyroidism; Polyarteritis Nodosa; Sympathectomy; Thiouracil

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Humans; Hyperthyroidism; Thiouracil; Thiourea

Topics: Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine; Iodine Isotopes; Neoadjuvant Therapy; Thiouracil

Topics: Hyperthyroidism; Sodium; Sodium, Dietary; Thiouracil

Topics: Diabetes Complications; Diabetes Mellitus; Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Blood Proteins; Hyperthyroidism; Iodine; Thiouracil

Topics: Humans; Hyperthyroidism; Leukemia; Leukemia, Myeloid; Thiouracil

Topics: Antifibrinolytic Agents; Goiter; Hyperthyroidism; Naphthoquinones; Thiouracil; Vitamin K

Topics: Antithyroid Agents; Hyperthyroidism; Thiazoles; Thiouracil

Topics: Humans; Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Thiouracil

Topics: Confusion; Databases, Genetic; Female; Humans; Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Humans; Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroidectomy; Thyrotoxicosis

Topics: Anemia; Anemia, Pernicious; Antacids; Anti-Bacterial Agents; Arthritis; Arthritis, Rheumatoid; Blood Pressure; Cortisone; Dibenzylchlorethamine; Dicumarol; Epilepsy; Ergot Alkaloids; Heart Failure; Heparin; Histamine Antagonists; Humans; Hyaluronoglucosaminidase; Hydantoins; Hypersensitivity; Hypertension; Hyperthyroidism; Imidazoles; Iodine; Iodine Isotopes; Kidney; Meperidine; Mephenesin; Methadone; Motion Sickness; Norepinephrine; Organomercury Compounds; Peptic Ulcer; Tetraethylammonium; Therapeutics; Thiouracil; Thrombosis; Veratrum; Vitamin B 12

Topics: Animals; Exophthalmos; Humans; Hyperthyroidism; Thiouracil; Weevils

Topics: Hyperthyroidism; Pregnancy; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Animals; Dogs; Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Angina Pectoris; Electrocardiography; Ergonovine; Ergot Alkaloids; Humans; Hyperthyroidism; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Hyperthyroidism; Methylthiouracil; Skin Temperature; Thiouracil

Topics: Hyperthyroidism; Thiouracil

Topics: Animals; Dogs; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Antithyroid Agents; Hyperthyroidism; Thiouracil

Topics: Family Practice; General Practice; Hyperthyroidism; Thiouracil

Topics: Estrogens; Hexestrol; Hyperthyroidism; Leadership; Methylthiouracil; Thiouracil

Topics: Blood; Humans; Hyperthyroidism; Pituitary Diseases; Pituitary Gland; Thiouracil; Thyrotropin

Topics: Blood; Hyperthyroidism; Iron; Thiouracil

Topics: Blood; Hyperthyroidism; Methylthiouracil; Thiouracil

Topics: Humans; Hyperthyroidism; Iodides; Iodine; Iodine Radioisotopes; Radioactivity; Thiouracil; Thiourea; Thyroid Gland

Topics: Hyperthyroidism; Iodides; Iodine; Iodine Isotopes; Methylthiouracil; Thiouracil; Thyroid Gland

Topics: Anemia; Estrogens; Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Liver; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Cardiomyopathies; Heart; Hyperthyroidism; Methylthiouracil; Propylthiouracil; Thiouracil; Thiourea; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Pulmonary emphysema is not an infrequent complication of tracheal compression due to goiter. In many cases the goiter is in the mediastinum and therefore overlooked. Among 13 patients with this combination of disease, chronic cough, dyspnea and wheezing were the chief respiratory symptoms. Ten of the 13 patients also had hyperthyroidism; in eight of the ten the disease was of the "masked" variety and both the thyrotoxicosis and the mediastinal mass were overlooked. Early recognition and surgical removal of substernal goiter may prevent or retard otherwise irreversible and progressive tracheobronchopulmonary disease. Medical management of such cases with thiouracil preparations may lessen the toxic symptoms but probably will not affect the mechanical compression of the trachea.

Topics: Cough; Dyspnea; Emphysema; Goiter; Goiter, Substernal; Humans; Hyperthyroidism; Mediastinum; Pulmonary Emphysema; Respiratory Sounds; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Humans; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Climacteric; Hyperthyroidism; Menopause; Thiouracil; Thiourea; Thyroid Gland

Topics: Hyperthyroidism; Pregnancy; Thiouracil; Thiourea; Thyroid Gland; Thyrotoxicosis

Topics: Aged; Humans; Hyperthyroidism; Musculoskeletal Diseases; Thiouracil; Thiourea; Thyroid Gland; Thyrotoxicosis

Topics: Arylsulfonates; Data Collection; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Humans; Hyperthyroidism; Iodine; Iodine Compounds; Potassium Iodide; Saliva; Thiouracil; Thiourea; Thyroid Gland

Topics: Arylsulfonates; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Adolescent; Humans; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Antineoplastic Agents, Hormonal; Hyperthyroidism; Thiouracil; Thiourea; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Parathyroid Glands; Thiouracil; Thyroid Gland; Thyroidectomy

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Female; Fetus; Humans; Hyperthyroidism; Pregnancy; Pregnancy Complications; Thiouracil

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Graves Disease; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Goiter; Humans; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Female; Fetus; Hyperthyroidism; Pregnancy; Pregnancy Complications; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Thiouracil

Topics: Goiter; Humans; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Goiter; Graves Disease; Hyperthyroidism; Liver; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Chronic Disease; Hyperthyroidism; Recurrence; Thiouracil; Thyroid Gland

Topics: Goiter; Graves Disease; Humans; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyroidectomy; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Disease Management; Hyperthyroidism; Thiopental; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Iodine; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Iodine; Thiouracil; Thyroid Gland

Topics: Humans; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Child; Humans; Hyperthyroidism; Infant; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Iodine; Thiouracil; Thyroid Gland

Topics: Female; Hyperthyroidism; Pregnancy; Pregnancy Complications; Thiouracil; Thyroid Gland

Topics: Disease Management; General Surgery; Humans; Hyperthyroidism; Iodides; Iodine; Preoperative Care; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Goiter; Goiter, Nodular; Graves Disease; Humans; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Humans; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Neoplasms; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Antithyroid Agents; Hyperthyroidism; Thiazoles; Thiouracil; Thiourea; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Barbital; Barbiturates; Hyperthyroidism; Propylthiouracil; Thiopental; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Exophthalmos; Goiter; Graves Disease; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Methylthiouracil; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Iodine; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Blood; Hyperthyroidism; Plasma; Regression Analysis; Thiouracil; Thyroid Gland; Urine

Topics: Hyperthyroidism; Thiouracil; Thyroid Diseases; Thyroid Gland

Topics: Disease Management; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyroidectomy

Topics: Adenoma; Adult; Humans; Hyperthyroidism; Neoplasms; Thiouracil; Thyroid Gland; Thyroid Neoplasms; Thyrotoxicosis

Topics: Exophthalmos; Goiter; Graves Disease; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Animals; Hyperthyroidism; Rats; Thiouracil; Thyroid Gland; Viscera

Topics: Hyperthyroidism; Propylthiouracil; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Diabetes Complications; Diabetes Mellitus; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Pregnancy; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hospitals; Hospitals, Military; Hyperthyroidism; Protestantism; Thiouracil; Thyroid Gland; Thyrotoxicosis; United States

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Child; Humans; Hyperthyroidism; Infant; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Postoperative Complications; Thiouracil; Thyroid Gland

Topics: Bone Marrow; Hyperthyroidism; Research; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Goiter; Humans; Hyperthyroidism; Thiouracil; Thiourea; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Diabetes Complications; Diabetes Mellitus; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Graves Disease; Humans; Hyperthyroidism; Thiouracil; Thyroid Gland; Viscera

Topics: Antithyroid Agents; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Humans; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Adenocarcinoma; Humans; Hyperthyroidism; Iodine Radioisotopes; Neoplasms, Second Primary; Thiouracil; Thyroid Gland; Thyroid Neoplasms

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Carcinoma; Hyperplasia; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyroid Neoplasms

Topics: Hyperthyroidism; Parathyroid Glands; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thiourea; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Humans; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Graves Disease; Humans; Hyperthyroidism; Iodine; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Agranulocytosis; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Hyperthyroidism; Thiouracil; Thyroid Gland