thiouracil and Hepatitis-B

A number of N- and S-substituted uracil and thiouracil glycosides were synthesized by coupling reaction of 5,6-dibenzyle pyrimidine derivatives with the corresponding acetobromosugar. The synthesized compounds were tested for their antiviral activity against hepatitis B virus. Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high antiviral activities.

Topics: Algorithms; Antiviral Agents; Drug Design; Glycosides; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thiouracil; Uracil; Viral Plaque Assay