thiouracil and Goiter

Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aminosalicylic Acids; Animals; Antimony; Barbiturates; Child; Child, Preschool; Cobalt; Depression, Chemical; Diazepam; Female; Goiter; Guinea Pigs; Humans; Hydantoins; Hypoglycemic Agents; Hypothyroidism; Infant, Newborn; Iodine; Lithium; Male; Perchlorates; Phenothiazines; Phenylbutazone; Pregnancy; Sulfonamides; Thiocyanates; Thiouracil; Thyroid Function Tests; Thyroid Gland; Xanthines

Topics: Basal Metabolism; Female; Fetal Death; Goiter; Humans; Hyperthyroidism; Infant; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methylthiouracil; Pregnancy; Pregnancy Complications; Propylthiouracil; Research; Thiouracil; Thyroid Function Tests; Thyrotropin; Thyroxine; Toxicology

Topics: Adult; Antithyroid Agents; Clinical Trials as Topic; Female; Follow-Up Studies; Goiter; Humans; Hyperthyroidism; Male; Middle Aged; Prognosis; Propylthiouracil; Thiouracil

Placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) represent two closely related angiogenic growth factors active as homodimers or heterodimers. Since goiters of the thyroid gland are extremely hypervascular, we investigated the expression of PlGF, VEGF and their receptors, Flt-1 and Flk-1/KDR, in a small panel of human goiters from patients with Graves's disease, in an animal model of thyroid goitrogenesis and in in vitro cultured thyroid cells. Here we report that the mRNA expression of PlGF, VEGF and their receptors is markedly enhanced in biopsies of goiters resected from Graves's patients. In vivo studies demonstrated that in the thyroid gland of thiouracil-fed rats, increased mRNA and protein expression of PIGF, VEGF, Flt-1 and Flk-1/KDR occurred subsequent to the rise in the serum thyroid stimulating hormone (TSH) levels and in parallel with thyroid capillary proliferation. In vitro studies confirmed the existence of such TSH-dependent paracrine communication between thyroid epithelial cells and endothelium since the conditioned medium collected from TSH-stimulated thyrocytes acquired mitogenic activity for human umbilical vein endothelial (HUVE) cells. Altogether, these data suggest that PlGF and VEGF, released by thyrocytes in response to the chronic activation of the TSH receptor pathway, may act through a paracrine mechanism on thyroid endothelium.

Topics: Animals; Antithyroid Agents; Cells, Cultured; Culture Media, Conditioned; Endothelial Growth Factors; Endothelium, Vascular; Goiter; Graves Disease; Humans; Lymphokines; Neovascularization, Pathologic; Placenta Growth Factor; Pregnancy Proteins; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Rats; Rats, Inbred Strains; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Thiouracil; Thyroid Gland; Thyrotropin; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors

Endothelin-1 (ET-1) is a major vasoconstrictor peptide, first found in endothelial cells, and later in many other tissues, including the thyroid gland. We analysed the expression of the ET-1 gene in the rat thyroid gland and changes in ET-1 mRNA and peptide levels in goiter development and involution, two circumstances characterised by vascular changes. Thyroid hyperplasia was induced in adult Wistar rats by feeding a low iodine diet (LID) supplemented with 0.25% thiouracil for 10 days, and LID alone for 2 further days (H.12 group). Involution was induced by injecting 100 micrograms iodide and refeeding a normal diet during 6 h, 12 h, and 24 h (I.6h, I.12h, I.24h groups). Rats fed a normal iodine diet were used as controls. A specific 488 bp cDNA corresponding to the known sequence of pre-pro ET-1 was found by RT-PCR from RNA extracts in all thyroid experimental groups, as well as in lung and kidney which were used as positive controls. RP-HPLC analysis showed that ET-1 immunoreactivity eluted similarly as mature ET-1. During hyperplasia, ET-1 mRNA and peptide levels were increased 3.5- and 5-fold respectively. The relative volume of the vascular bed was more than doubled. During iodide-induced involution, the glandular ET-1 mRNA level remained elevated. The concentration of ET-1 peptide increased and was significantly greater at 12 h involution than in the H.12 group. At this time, the capillary reticulum reverted to individual capillaries and the vascular bed was significantly reduced. These data demonstrate that the ET-1 gene is expressed in the rat thyroid gland and that the ET-1 mRNA and peptide levels are increased during thyroid hyperplasia and remain elevated during a phase of rapid iodide-induced involution. These data suggest that changes in ET-1 production may play a role in control of thyroid gland trophic regulation and vascularity.

Topics: Animals; Base Sequence; Chromatography, High Pressure Liquid; Diet; Endothelins; Gene Expression; Goiter; Iodine; Male; Molecular Sequence Data; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Thiouracil; Thyroid Gland

The effects of a goitrogen (thiouracil) on the structural variations of the thyroid gland were studied in male buffalo calves. Following the treatment, the thyroid became enlarged and both the weight and the size of the gland were significantly increased (P less than 0.01). Hyperplasia and hypertrophy of the gland were correlated with a significant increase of thyroidal uptake of 131I. The height and number of the follicular cells were significantly increased (P less than 0.01). The follicles were small and had vacuolations in the colloid. The colloid content of the follicles became reduced. The vascularity of the gland was appreciably increased.

Topics: Animal Feed; Animals; Buffaloes; Goiter; Hypertrophy; Male; Organ Size; Thiouracil; Thyroid Gland

Topics: Antithyroid Agents; Chemistry; Contraceptives, Oral; Female; Goiter; History, 19th Century; History, 20th Century; Humans; Hyperthyroidism; Hypothyroidism; Imidazoles; Iodine Radioisotopes; Lithium; Perchlorates; Pregnancy; Thiouracil; Thyroid (USP); Thyroid Diseases; Thyroid Hormones; Thyroid Neoplasms; Thyroxine; Triiodothyronine

Topics: Azides; Chemical Phenomena; Chemistry; Dimethyl Sulfoxide; Goiter; Heterocyclic Compounds; Imides; Iodine; Kinetics; Models, Biological; Nitrogen; Phthalic Acids; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Succinimides; Thiouracil; Thiourea; Thyroid Gland; Time Factors

Topics: Acid Phosphatase; Animals; Cathepsins; Centrifugation, Density Gradient; Glucuronidase; Goiter; Hydrogen-Ion Concentration; Hydrolysis; Iodides; Iodine Radioisotopes; Lysosomes; Male; Polyethylene Glycols; Rats; Thiouracil; Thyroglobulin; Thyroid Gland; Thyrotropin; Thyroxine

Topics: Animals; Dose-Response Relationship, Drug; Goiter; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Rats; Structure-Activity Relationship; Thiouracil; Thyronines; Thyroxine

Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Bone and Bones; Calcification, Physiologic; Calcium; Chickens; Deficiency Diseases; Erythropoiesis; Goiter; Hypothyroidism; Iodine; Iodine Radioisotopes; Male; Mitochondria, Muscle; Oxygen Consumption; Thiouracil; Thyroid Gland; Vitamin D Deficiency; Vitamin E

Topics: Animals; Chromatography, Thin Layer; Goiter; Mass Spectrometry; Methylation; Optical Rotation; Rats; Thiouracil; Thyronines

Topics: Adolescent; Adult; Age Factors; Antithyroid Agents; Carbimazole; Child; Goiter; Humans; Hyperthyroidism; Hypothyroidism; Iodine; Iodine Isotopes; Propranolol; Thiouracil; Thyroid Diseases; Thyroxine; Triiodothyronine

Topics: Animals; Chlorates; Diet; Glucuronidase; Goiter; Insulin; Iodine; Male; Rats; Thiocyanates; Thiouracil; Thyroid Gland; Thyroid Hormones; Thyroidectomy

Topics: Animals; Autoradiography; Blood Proteins; Chromatography; Chromatography, Paper; Diet; Female; Goiter; Iodine; Iodine Isotopes; Male; Methylamines; Organ Size; Pituitary Gland; Protein Binding; Rats; Tetracycline; Thiouracil; Thyroid Gland; Thyroidectomy; Thyroxine; Triiodothyronine

Topics: Animals; Chromatography, DEAE-Cellulose; Electrophoresis; Goiter; Hydrogen-Ion Concentration; Iodine; Isoelectric Focusing; Swine; Thiouracil; Thyroglobulin; Thyroid Gland; Ultracentrifugation; Urea

Topics: Aged; Arthritis, Rheumatoid; Autopsy; Diabetes Complications; Female; Goiter; Goiter, Nodular; Heart Failure; Humans; Hyperthyroidism; Iodine Isotopes; Thiouracil; Thyroid Crisis; Thyroid Gland

Topics: Acclimatization; Altitude; Animals; Female; Goiter; Hyperthyroidism; Hypothyroidism; Iodine; Rats; Rats, Inbred Strains; Thiouracil; Thyroid Function Tests; Thyroid Gland; Thyroidectomy; Thyrotropin; Thyroxine

Topics: Animals; Choline; Dextrans; Drug Evaluation; Goiter; Male; Organ Size; Propylthiouracil; Rats; Thiouracil; Thyroid Gland

Topics: Animals; Biological Assay; Diet; Female; Goiter; Iodine; Organ Size; Pharmacopoeias as Topic; Rats; Tablets; Thiouracil; Thyroid Hormones; United States

Topics: Child; Goiter; Goiter, Endemic; Humans; Iodine; Spain; Thiouracil; Thyroxine

Topics: Animals; Arteries; Chronic Disease; Goiter; Guinea Pigs; Humans; Thiouracil; Thyroid Gland; Thyroidectomy; Thyrotropin

Topics: Animals; Carbon Isotopes; Centrifugation, Density Gradient; Goiter; Male; Phenylalanine; Polynucleotides; Protein Biosynthesis; Proteins; Rats; Ribosomes; RNA, Messenger; Thiouracil; Thyroid Gland; Thyrotropin; Uracil Nucleotides

Topics: Adolescent; Age Factors; Child; Child, Preschool; Deficiency Diseases; Disease Reservoirs; Female; Goiter; Humans; Hyperthyroidism; Imidazoles; Iodine; Male; Sex Factors; Thiouracil; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyroxine; Tissue Extracts; Triiodothyronine

Topics: Animals; Anura; Colloids; Goiter; Microscopy, Electron; Perchlorates; Thiocyanates; Thiouracil; Thiourea

Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Congenital Hypothyroidism; Cushing Syndrome; Female; Glucocorticoids; Goiter; Humans; Hydrocortisone; Hyperparathyroidism; Hyperthyroidism; Hypocalcemia; Hypoparathyroidism; Infant, Newborn; Iodine; Maternal-Fetal Exchange; Parathyroid Diseases; Pregnancy; Thiouracil; Thyroid Hormones

Topics: Acrylic Resins; Animals; Autoradiography; Carbon Isotopes; Electrophoresis, Disc; Gels; Goiter; Humans; Hypothyroidism; Immune Sera; Immunodiffusion; Iodine; Iodine Isotopes; Iodoproteins; Methods; Proteins; Rats; Thiouracil; Thyroglobulin; Thyroid Hormones; Tissue Extracts

Topics: Animals; Chemistry, Organic; Goiter; Organic Chemistry Phenomena; Rats; Thiouracil; Thyroid Hormones

Topics: Adolescent; Adult; Antithyroid Agents; Blood Cell Count; Diagnosis, Differential; Diagnostic Errors; Female; Goiter; Heart Auscultation; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Methylthiouracil; Myxedema; Nervous System Diseases; Neurotic Disorders; Propylthiouracil; Radioisotope Dilution Technique; Thiazoles; Thiouracil; Thiourea; Thyrotropin

Topics: Adolescent; Adult; Aged; Antithyroid Agents; Basal Metabolism; Chromatography; Female; Goiter; Humans; Hypothyroidism; Iodine Isotopes; Male; Middle Aged; Radionuclide Imaging; Thiouracil; Thyroid Function Tests

Topics: Animals; Body Weight; Brain; Ear, Middle; Goiter; Hypertrophy; Hypothalamus; Male; Methods; Organ Size; Rats; Thiouracil; Thyroid Gland; Thyrotropin

Topics: Animals; Body Weight; DNA; Goiter; Hypophysectomy; Iodides; Iodine; Iodine Isotopes; Male; Mice; Organ Size; Pituitary Gland; Proteins; RNA; Thiouracil; Thyroid Gland; Thyroid Hormones; Thyrotropin; Trichloroacetic Acid

Topics: Animals; Diet; Female; Goiter; Iodine Isotopes; Manihot; Nigeria; Rats; Thiouracil; Thyroid Function Tests; Thyroid Gland

Topics: Antithyroid Agents; Carbon Isotopes; Chromatography; Cytosine Nucleotides; DNA; Glucosyltransferases; Goiter; Metabolism; Orotic Acid; Pharmacology; Phosphotransferases; Rats; Research; RNA; Spectrophotometry; Thiouracil; Thyroid Gland; Uracil; Uracil Nucleotides

Topics: 17-Ketosteroids; Adolescent; Adult; Animals; Estradiol; Estrogens; Female; Follow-Up Studies; Goiter; Humans; Iodine Isotopes; Male; Metabolism, Inborn Errors; Mice; Neoplasm Metastasis; Pituitary Neoplasms; Radiography, Thoracic; Rats; Thiouracil; Thyroid Neoplasms; Thyrotropin; Thyroxine; Triiodothyronine

Topics: Antithyroid Agents; Chlorides; Cobalt; Goiter; Graves Disease; Humans; Microscopy; Pathology; Thiouracil; Thyroid Diseases; Thyroid Neoplasms; Thyroiditis; Thyroiditis, Autoimmune; Toxicology

Topics: Anti-Infective Agents, Local; Antithyroid Agents; Basal Metabolism; Diet; Goiter; Humans; Iodides; Iodine; Perchlorates; Pharmacology; Thiocyanates; Thiouracil; Thyroid Gland; Thyroxine; Triiodothyronine

Topics: Carcinoma; Endometriosis; Endometritis; Female; Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine Isotopes; Myxedema; Neoplasms; Ovarian Neoplasms; Salpingitis; Thiouracil; Thyroid Diseases; Thyroidectomy; Tuberculosis; Tuberculosis, Female Genital; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: Autoradiography; Electrophoresis; Goiter; Humans; Hyperthyroidism; Iodates; Iodides; Iodine; Iodine Isotopes; Methylthiouracil; Proteins; Thiouracil; Thyroglobulin; Thyroid Gland

Topics: Aging; Antithyroid Agents; Exophthalmos; Goiter; Humans; Hyperthyroidism; Iodides; Iodine; Iodine Isotopes; Postoperative Complications; Thiocyanates; Thiouracil; Thyroidectomy

Topics: Animals; Colloids; Cortisone; Cricetinae; Goiter; Hyperplasia; Hyperthyroidism; Iodine; Pharmacology; Research; Sulfadiazine; Thiocyanates; Thiouracil; Thyroiditis; Triiodothyronine

Topics: Alkaline Phosphatase; Animals; Biological Assay; Biomedical Research; Chickens; Goiter; Meat; Pharmacology; Physiology; Poultry; Research; Thiouracil; Thyroid Gland; Thyroxine

Topics: Adrenergic Agents; Exophthalmos; Goiter; Graves Disease; Guanethidine; Humans; Thiouracil; Thyrotoxicosis

Topics: Animals; Biological Assay; Goiter; Hypoxia; Mice; Pharmacology; Research; Thiouracil; Thyroid Function Tests; Thyroid Hormones

Topics: Antithyroid Agents; Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine Isotopes; Methylthiouracil; Perchlorates; Radiotherapy; Thiouracil; Thiourea; Thyroidectomy

Topics: Goiter; Iodides; Iodine; Iodine Radioisotopes; Propylthiouracil; Thiouracil

Topics: Goiter; Propylthiouracil; Thiouracil; Thyroxine

Topics: Exophthalmos; Goiter; Graves Disease; Graves Ophthalmopathy; Humans; Hyaluronoglucosaminidase; Iodine Isotopes; Prednisone; Thiouracil; Thyrotropin

Topics: Animals; Antithyroid Agents; Goiter; Iodides; Iodine; Rats; Sodium Chloride; Thiouracil

Topics: Animals; Goiter; Iodides; Iodine; Rats; Thiouracil; Thyroxine; Triiodothyronine

Topics: Combined Modality Therapy; Goiter; Hyperthyroidism; Iodine; Iodine Radioisotopes; Methylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Goiter; Reserpine; Thiouracil

Topics: Goiter; Humans; Pituitary Gland; Pituitary Gland, Anterior; Thiouracil

Topics: Goiter; Guinea Pigs; Hypothalamus; Pituitary Gland; Propylthiouracil; Thiouracil; Thyrotropin

Topics: Animals; Biomedical Research; Goiter; Iodides; Iodine; Propylthiouracil; Rats; Thiouracil

Topics: Child; Female; Goiter; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal Nutritional Physiological Phenomena; Nutritional Physiological Phenomena; Pregnancy; Prenatal Nutritional Physiological Phenomena; Thiouracil; Vegetables

Topics: Colloids; Goiter; Thiouracil

Topics: Diencephalon; Goiter; Goiter, Endemic; Humans; Iodine; Thiouracil; Thyroid Diseases

Topics: Goiter; Leadership; Prednisolone; Propylthiouracil; Thiouracil

Topics: Cholesterol; Formates; Goiter; Lipid Metabolism; Liver; Thiouracil; Thyrotropin; Thyroxine

Topics: Child; Disease; Diseases in Twins; Female; Goiter; Humans; Hyperthyroidism; Infant; Pregnancy; Propylthiouracil; Thiouracil; Twins

Topics: Child; Female; Goiter; Humans; Hyperthyroidism; Infant; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Thiouracil; Thyroid Diseases

Topics: Goiter; Humans; Hyperthyroidism; Methylthiouracil; Syndrome; Thiouracil

Topics: Goiter; Hyperkinesis; Hyperthyroidism; Hypothalamus; Methylthiouracil; Neurosecretion; Pharmaceutical Preparations; Thiouracil

Topics: Goiter; Propylthiouracil; Thiouracil; Thyroxine

Topics: Goiter; Guinea Pigs; Methylthiouracil; Thiouracil; Thyronines; Thyroxine

Topics: Goiter; Thiouracil

Topics: Animals; Estradiol; Estrogens; Goiter; Hyperthyroidism; Rats; Thiouracil

Topics: Acetylcholine; Animals; Cholinergic Agents; Cholinesterase Inhibitors; Female; Goiter; Hyperplasia; Neoplasms; Neostigmine; Pregnancy; Pregnancy Complications; Rats; Thiouracil; Thyroid Gland; Thyroid Neoplasms

Topics: Child; Eating; Goiter; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Mothers; Propylthiouracil; Thiouracil

Topics: Child; Goiter; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Propylthiouracil; Thiouracil

Topics: Goiter; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Adrenocorticotropic Hormone; Goiter; Propylthiouracil; Thiouracil

Topics: Analgesics; Animals; Goiter; Propylthiouracil; Rats; Thiouracil

Topics: Goiter; Iodides; Iodine; Iodine Compounds; Methylthiouracil; Musculoskeletal Physiological Phenomena; Thiouracil; Thyroxine

Topics: Cystine; Dimercaprol; Goiter; Hyperplasia; Hypertrophy; Methionine; Methylthiouracil; Pharmaceutical Preparations; Thiouracil; Thyroid Gland; Viscera

Topics: Cystine; Dimercaprol; Goiter; Hyperplasia; Hypertrophy; Methionine; Methylthiouracil; Thiouracil

Topics: Child; Female; Goiter; Humans; Hyperthyroidism; Infant; Infant, Newborn; Pregnancy; Thiouracil

Topics: Goiter; Humans; Hyperthyroidism; Iodine; Iodine Radioisotopes; Myxedema; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Adrenocorticotropic Hormone; Goiter; Humans; Thiouracil

Topics: Goiter; Methylthiouracil; Thiouracil; Vitamin E

Topics: Goiter; Hyperthyroidism; Propylthiouracil; Thiouracil

Topics: Estrogens; Goiter; Gonadal Steroid Hormones; Humans; Progesterone; Thiouracil

Topics: Goiter; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Antithyroid Agents; Goiter; Humans; Thiouracil

Topics: Goiter; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Disease; Female; Goiter; Humans; Hyperplasia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Iodides; Iodine; Mothers; Pregnancy; Thiouracil; Thyroid Diseases; Thyroid Gland

Topics: Goiter; Hyperthyroidism; Thiouracil

Topics: Agranulocytosis; Goiter; Graves Disease; Humans; Propylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Goiter; Graves Disease; Humans; Hyperthyroidism; Iodine; Iodine Isotopes; Neoadjuvant Therapy; Thiouracil

Topics: Animals; Goiter; Guinea Pigs; Propylthiouracil; Rats; Thiouracil

Topics: Antifibrinolytic Agents; Goiter; Hyperthyroidism; Naphthoquinones; Thiouracil; Vitamin K

Topics: Disease Management; Goiter; Graves Disease; Propylthiouracil; Thiouracil

Topics: Animals; Chickens; Genetics; Goiter; Meat; Thiouracil

Topics: Goiter; Graves Disease; Humans; Iodides; Iodine; Iodine Radioisotopes; Thiouracil; Thyroid Gland

Topics: Exophthalmos; Goiter; Graves Disease; Humans; Thiouracil; Thyroid Gland; Thyroidectomy

Topics: Anemia; Estrogens; Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Liver; Thiouracil; Thyroid Gland

Topics: Goiter; Logic; Thiouracil; Thyroid Gland

Topics: Goiter; Graves Disease; Humans; Methylthiouracil; Sulfanilamide; Sulfanilamides; Sulfonamides; Thiouracil; Thyroid Gland

Topics: Chronic Disease; Goiter; Graves Disease; Recurrence; Thiouracil

Topics: Electrocardiography; Exophthalmos; Goiter; Graves Disease; Humans; Thiouracil; Thiourea

Pulmonary emphysema is not an infrequent complication of tracheal compression due to goiter. In many cases the goiter is in the mediastinum and therefore overlooked. Among 13 patients with this combination of disease, chronic cough, dyspnea and wheezing were the chief respiratory symptoms. Ten of the 13 patients also had hyperthyroidism; in eight of the ten the disease was of the "masked" variety and both the thyrotoxicosis and the mediastinal mass were overlooked. Early recognition and surgical removal of substernal goiter may prevent or retard otherwise irreversible and progressive tracheobronchopulmonary disease. Medical management of such cases with thiouracil preparations may lessen the toxic symptoms but probably will not affect the mechanical compression of the trachea.

Topics: Cough; Dyspnea; Emphysema; Goiter; Goiter, Substernal; Humans; Hyperthyroidism; Mediastinum; Pulmonary Emphysema; Respiratory Sounds; Thiouracil; Thyrotoxicosis

Topics: Goiter; Goiter, Endemic; Iodides; Iodine; Thiouracil; Thiourea

Topics: Goiter; Halogens; Iodides; Iodine; Iodine Isotopes; Thiouracil; Thiourea

Topics: Exophthalmos; Goiter; Graves Disease; Thiouracil; Thiourea

Topics: Endocrine System Diseases; Goiter; Musculoskeletal Diseases; Thiouracil; Thiourea; Thyroid Gland

Topics: Goiter; Graves Disease; Graves Ophthalmopathy; Humans; Propylthiouracil; Thiouracil

Topics: Goiter; Thiouracil; Thiourea; Thyrotoxicosis

Topics: Exophthalmos; Goiter; Graves Disease; Thiouracil; Thiourea; Thyrotoxicosis

Topics: Goiter; Humans; Thiouracil; Thyrotoxicosis

Topics: Goiter; Humans; Thiouracil; Thyrotoxicosis

Topics: Goiter; Graves Disease; Thiouracil

Topics: Goiter; Graves Disease; Propylthiouracil; Thiouracil; Thyrotoxicosis

Topics: Goiter; Humans; Hyperthyroidism; Thiouracil; Thyrotoxicosis

Topics: Exophthalmos; Goiter; Graves Disease; Humans; Hyperthyroidism; Thiouracil

Topics: Goiter; Humans; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Goiter; Graves Disease; Hyperthyroidism; Liver; Thiouracil; Thyroid Gland

Topics: Goiter; Graves Disease; Humans; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyroidectomy; Thyrotoxicosis

Topics: Goiter; Goiter, Nodular; Graves Disease; Humans; Hyperthyroidism; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Exophthalmos; Goiter; Graves Disease; Thiouracil

Topics: Exophthalmos; Goiter; Graves Disease; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Exophthalmos; Goiter; Graves Disease; Hyperthyroidism; Thiouracil; Thyroid Gland

Topics: Exophthalmos; Goiter; Graves Disease; Humans; Hypertrophy; Thiouracil; Thyroid Gland

Topics: Goiter; Hypertrophy; Neoplasms; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Goiter; Hypertrophy; Thiouracil; Thyroid Gland; Thyrotoxicosis

Topics: Exophthalmos; Goiter; Graves Disease; Thiouracil

Topics: Antithyroid Agents; Goiter; Thiouracil; Thiourea

Topics: Goiter; Humans; Hyperthyroidism; Thiouracil; Thiourea; Thyroid Gland

Topics: Goiter; Hyperplasia; Methylthiouracil; Pharmaceutical Preparations; Thiouracil; Thiourea; Thyroid Gland

Topics: Animals; Goiter; Pyrimidines; Rats; Thiouracil