thiouracil and Arteriosclerosis

The aim of this study was to investigate the antiatherogenic effects of 17 beta-estradiol and 17 alpha-estradiol and its derivative J811 (estra-1,3,5(10),8-tetraene-3, 17 alpha-diol), having a non-feminizing effect and high antioxidant potential, in male rabbits.. Male White-Russian rabbits weighing 2.1-2.6 kg were fed either a standard or a high-cholesterol (200 mg/kg) diet, with thyroid function-inhibiting thiouracil (20 mg/kg) combined with cholic acid (40 mg/kg) administered daily in sunflower oil for 3 months. During the last month of the study, estrogens were administered by gavage at a dose of 0.02 or 0.1 mg/kg.. All three estrogens exerted remarkable antiatherosclerotic effects. Decreases in serum and aortic-wall lipid parameters and the index of atherogenicity were dependent on estrogen dose. Morphological evaluation of the aortic wall (height of plaques, size of plaque relative to aortic half-circumference) showed only weak therapeutic effects with all three estrogens. It is an open question whether the treatment period was too short to reverse the above changes. On the other hand, the data clearly suggest that 17 alpha-estradiol and J811 offer new perspectives for the prevention of atherosclerosis in men, which is similar to that found with 17 beta-estradiol in women.

Topics: Animals; Anticholesteremic Agents; Antithyroid Agents; Arteriosclerosis; Cholesterol, HDL; Diet, Atherogenic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Estradiol; Free Radical Scavengers; Hypercholesterolemia; Male; Rabbits; Random Allocation; Sex Characteristics; Thiouracil

Topics: Animals; Aorta; Arteriosclerosis; Cholesterol; Chondroitin; Dietary Fats; Female; Glycosaminoglycans; Heparitin Sulfate; Hexosamines; Hyaluronic Acid; Phospholipids; Rabbits; Thiouracil; Thyroxine

Topics: Animals; Arteriosclerosis; Cholesterol; Diet, Atherogenic; Dietary Fats; Dogs; Fatty Acids, Essential; Female; Linoleic Acids; Male; Thiouracil

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Aorta; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Calcium; Cholesterol; Diet, Atherogenic; Female; Magnesium; Male; Rats; Thiouracil

Topics: Adipose Tissue; Arteriosclerosis; Atherosclerosis; Cholesterol; Collagen; Connective Tissue; Diet; Diet, Atherogenic; Epinephrine; Fatty Acids; Hexosamines; Histocytochemistry; Hydroxyproline; Pharmacology; Rats; Research; Skin; Thiouracil

Topics: Animals; Aorta; Arteriosclerosis; Atherosclerosis; Cholesterol; Dietary Fats; Dogs; Fatty Acids; Lipid Metabolism; Lipids; Liver; Phospholipids; Research; Thiouracil

Topics: Anemia; Arteriosclerosis; Cholesterol; Chromium Isotopes; Diet, Atherogenic; Dietary Fats; Erythrocytes; Hematocrit; Hemoglobins; Metabolism; Pyridoxine; Rats; Research; Starvation; Thiouracil; Tryptophan; Xanthurenates

Topics: Allografts; Animals; Aorta; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Arteriosclerosis; Atherosclerosis; Blood Vessels; Cholesterol; Dogs; Hypercholesterolemia; Pathology; Research; Thiouracil; Transplantation, Homologous; Vascular Surgical Procedures

Topics: Arteriosclerosis; Atherosclerosis; Bile Acids and Salts; Cholesterol; Diet; Diet, Atherogenic; Dietary Fats; Dogs; Pathology; Research; Salts; Thiouracil

Topics: Animals; Arteriosclerosis; Cholesterol; Dietary Fats; Fats; Glycine max; Linoleic Acid; Linoleic Acids; Liver; Rats; Thiouracil

Topics: Animals; Arteries; Arteriosclerosis; Diet, Atherogenic; Methoxamine; Rats; Thiouracil; Tunica Media

Topics: Animals; Arteriosclerosis; Atherosclerosis; Cholesterol; Epinephrine; Rabbits; Thiouracil

Albino rats maintained for 50 to 60 days on rations containing cholesterol, sodium cholate, and thiouracil were found to be highly susceptible to the lethal effects of infection with Mycobacterium tuberculosis. Maximum loss of resistance occurred only when all three components were present in a single ration. A lesser degree of susceptibility resulted from the deletion of one or more of the factors from the diet. Animals maintained on control rations never died of the infection. Histopathological studies of stained sections of tissues of infected animals revealed that the reaction of the host to the bacillus was more extensive and less well contained in animals fed the complete atherogenic ration than in the controls.

Topics: Animals; Arteriosclerosis; Cholesterol; Diet; Diet, Atherogenic; Rats; Thiouracil; Tuberculosis

Topics: Animals; Aorta; Arteriosclerosis; Chickens; Cholesterol; Male; Sulfur; Thiouracil; Thyroid Hormones; Thyroxine

Topics: Animals; Arteriosclerosis; Diet; Humans; Hypercholesterolemia; Rats; Sitosterols; Steroids; Thiouracil

Topics: Animals; Arteries; Arteriosclerosis; Cholesterol; Diet; Fats; Humans; Hypercholesterolemia; Rats; Sitosterols; Steroids; Thiouracil

Topics: Animals; Arteriosclerosis; Atherosclerosis; Cholesterol; Dogs; Hypertension; Hypertension, Renal; Thiouracil

Topics: Animals; Arteriosclerosis; Blood Proteins; Cholesterol; Diet; Diet, Atherogenic; Dogs; Humans; Lipoproteins; Thiouracil

Topics: Animals; Arteriosclerosis; Cholesterol; Dogs; Humans; Thiouracil; Thiourea

Topics: Animals; Arteriosclerosis; Cholesterol; Dogs; Humans; Thiouracil; Thiourea

Topics: Animals; Arteriosclerosis; Cholesterol; Dogs; Thiouracil; Thiourea

Topics: Animals; Arteriosclerosis; Atherosclerosis; Cholesterol; Dogs; Eating; Thiouracil