thiouracil and Adenoma

thiouracil has been researched along with Adenoma* in 9 studies

Reviews

3 review(s) available for thiouracil and Adenoma

ArticleYear
Hyperthyroidism.
    British medical journal, 1972, May-06, Volume: 2, Issue:5809

    Topics: Adenoma; Carbimazole; Child; Eye Manifestations; Female; gamma-Globulins; Graves Disease; Hot Temperature; Humans; Hyperkinesis; Hyperthyroidism; Iodides; Iodine Isotopes; Long-Acting Thyroid Stimulator; Pregnancy; Sweating; Thiouracil; Thyroid Function Tests; Thyroidectomy; Thyroxine

1972
Experimental thyroid tumours.
    Neoplastic disease at various sites, 1970, Volume: 6

    Topics: Adenoma; Animals; Dogs; Fluorenes; Humans; Iodine; Iodine Radioisotopes; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Radiation Effects; Radiotherapy; Rats; Sheep; Thiouracil; Thiourea; Thyroid Gland; Thyroid Neoplasms; Thyroidectomy; Transplantation, Homologous

1970
THYROIDITIS IN CHILDHOOD.
    Advances in pediatrics, 1964, Volume: 13

    Topics: Adenoma; Alpha-Globulins; Antibody Formation; Antigens; Autoantibodies; Autoimmune Diseases; Beta-Globulins; Blood Proteins; Child; Humans; Hyperthyroidism; Hypothyroidism; Organ Specificity; Serum Globulins; Species Specificity; Thiouracil; Thyroid Function Tests; Thyroid Hormones; Thyroid Neoplasms; Thyroiditis; Thyroiditis, Autoimmune; Thyrotropin; Triiodothyronine

1964

Other Studies

6 other study(ies) available for thiouracil and Adenoma

ArticleYear
Involvement of glycogen synthase kinase-3beta signaling and aberrant nucleocytoplasmic localization of retinoblastoma protein in tumor promotion in a rat two-stage thyroid carcinogenesis model.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2010, Volume: 62, Issue:3

    To investigate the cell cycle kinetics during the tumor promotion process induced by hypothyroidism in a rat model of thyroid follicular cell carcinogenesis, immunohistochemical analysis of cell cycle molecules and related signaling molecules was performed in conjunction with analysis of cell proliferation activity in an initiation-promotion model. Male F344 rats were injected with N-bis(2-hydroxypropyl)nitrosamine, and one week later treated with 6-propyl-2-thiouracil (PTU) at 12ppm in the drinking water for 4, 10 or 15 weeks. At each time point, proliferative lesions increased the expression of cyclin A, cyclin D, cyclin E and cyclin-dependent kinase (Cdk)-2, in association with the development of lesion stages from the early focal hyperplasia to the late carcinoma, while a subpopulation of proliferative lesions showed decreased numbers of both cell division cycle-2- and Ki-67-positive cells at week 15 compared with that at week 10, suggesting a reduced promoting effect of serum thyroid-stimulating hormone in the sensitive cellular population after long-term exposure to PTU. On the other hand, increased immunolocalization of phosphorylated and inactive glycogen synthase kinase (GSK)-3beta was observed in a subpopulation of proliferative lesions, in parallel with the cyclins and Cdk2. Nuclear immunoreactivity of phosphorylated and inactive retinoblastoma (Rb) protein was also increased in association with lesion development, with carcinomas showing increased cytoplasmic localization. The results suggest that proliferative lesions activate the cell cycle machinery following tumor promotion via a regulatory mechanism involving inactivation of GSK3beta and Rb protein, the latter signaling mechanism involving its aberrant nucleocytoplasmic transport for the acquisition of a malignant phenotype.

    Topics: Adenocarcinoma, Follicular; Adenoma; Animals; Carcinogens; Cell Cycle Proteins; Cell Nucleus; Cell Transformation, Neoplastic; Cytoplasm; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; Male; Nitrosamines; Protein Transport; Rats; Rats, Inbred F344; Retinoblastoma Protein; Signal Transduction; Thiouracil; Thyroid Neoplasms

2010
[Therapy of thyrotoxicosis].
    Helvetica medica acta, 1968

    Topics: Adenoma; Graves Disease; Humans; Hyperthyroidism; Iodine; Iodine Isotopes; Perchlorates; Thiouracil; Thyroglobulin; Thyroid Neoplasms; Thyroidectomy

1968
[Treatment of hyperthyroidism].
    Schweizerische medizinische Wochenschrift, 1967, Oct-14, Volume: 97, Issue:41

    Topics: Adenoma; Antithyroid Agents; Graves Disease; Humans; Hyperthyroidism; Imidazoles; Iodine; Perchlorates; Potassium; Radiography; Radionuclide Imaging; Sulfhydryl Compounds; Thiouracil; Thyroid Neoplasms; Thyroidectomy

1967
[The development of thyroid carcinoma in rats treated with thiouracil and 2-acetaminofluoren].
    Beitrage zur pathologischen Anatomie und zur allgemeinen Pathologie, 1965, Volume: 132, Issue:2

    Topics: Adenoma; Animals; Carcinogens; Carcinoma; Fluorenes; Methylthiouracil; Neoplasm Metastasis; Neoplasms, Experimental; Propylthiouracil; Rats; Thiouracil; Thyroid Neoplasms

1965
[Pregnancy and thiouracil adenoma of the thyroid gland].
    Zeitschrift fur Geburtshilfe und Gynakologie, 1955, Volume: 144, Issue:3

    Topics: Adenoma; Humans; Neoplasms; Pregnancy; Thiouracil; Thyroid Gland; Viscera

1955
A case of solitary toxic adenoma of the thyroid in an adult with an evaluation of the pre- and postoperative use of thiouracil in thyrotoxicosis.
    Staff proceedings. Hillcrest Medical Center (Tulsa, Okla.), 1946

    Topics: Adenoma; Adult; Humans; Hyperthyroidism; Neoplasms; Thiouracil; Thyroid Gland; Thyroid Neoplasms; Thyrotoxicosis

1946