thiotepa has been researched along with Thrombopenia in 28 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously demonstrated that Busulfan-Thiotepa (Bu-Thio) and ASCT effectively treated patients with locally relapsed medulloblastoma after surgery and conventional chemotherapy." | 9.11 | High-dose busulfan and thiotepa followed by autologous stem cell transplantation (ASCT) in previously irradiated medulloblastoma patients: high toxicity and lack of efficacy. ( Benhamou, E; Couanet, D; Fillipini, B; Grill, J; Habrand, JL; Hartmann, O; Kalifa, C; Valteau-Couanet, D, 2005) |
| "The dose-limiting toxicities were interstitial pneumonitis and mucositis with moderately severe diarrhea (n = 3) and rash (n = 3)." | 6.69 | Repetitive high-dose therapy with cyclophosphamide, thiotepa and docetaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer: results of a phase I study. ( Blakey, D; Brettell, M; Briggs, P; Chapple, P; Eerhard, S; Gates, P; Januszewicz, EH; Juneja, S; Prince, HM; Quinn, M; Richardson, G; Rischin, D; Scarlett, J; Seymour, JF; Toner, GC; Wolf, M, 2000) |
| "We previously demonstrated that Busulfan-Thiotepa (Bu-Thio) and ASCT effectively treated patients with locally relapsed medulloblastoma after surgery and conventional chemotherapy." | 5.11 | High-dose busulfan and thiotepa followed by autologous stem cell transplantation (ASCT) in previously irradiated medulloblastoma patients: high toxicity and lack of efficacy. ( Benhamou, E; Couanet, D; Fillipini, B; Grill, J; Habrand, JL; Hartmann, O; Kalifa, C; Valteau-Couanet, D, 2005) |
| "Autologous stem cell transplantation (ASCT) with high-dose thiotepa and busulfan is a treatment option for patients with central nervous system (CNS) lymphoma." | 3.96 | Secondary failure of platelet recovery in patients treated with high-dose thiotepa and busulfan followed by autologous stem cell transplantation. ( Aiba, A; Hishizawa, M; Kitano, T; Kondo, T; Nishikori, M; Shimazu, Y; Shindo, T; Takaori-Kondo, A; Wada, F; Watanabe, M, 2020) |
| "In the phase 1/2 study, 75 breast cancer patients underwent a bone marrow harvest and myeloablative STAMP V chemotherapy and were randomized to receive placebo or one of three doses of PEG-rHuMGDF." | 2.70 | The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation. ( Abboud, CN; Beveridge, R; Cruickshank, S; Frei-Lahr, D; Holden, J; Macri, M; Menchaca, D; Schuster, MW; Waller, EK, 2002) |
| "The dose-limiting toxicities were interstitial pneumonitis and mucositis with moderately severe diarrhea (n = 3) and rash (n = 3)." | 2.69 | Repetitive high-dose therapy with cyclophosphamide, thiotepa and docetaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer: results of a phase I study. ( Blakey, D; Brettell, M; Briggs, P; Chapple, P; Eerhard, S; Gates, P; Januszewicz, EH; Juneja, S; Prince, HM; Quinn, M; Richardson, G; Rischin, D; Scarlett, J; Seymour, JF; Toner, GC; Wolf, M, 2000) |
| " Thirty-five previously treated advanced breast cancer patients received 70 cycles (median, 2 cycles/patient; range, 1-6) of 1600 mg of oral sustained release pentoxifylline every 8 h for 4 doses in combination with escalating doses of i." | 2.68 | Dose escalation of N,N',N"-triethylenethiophosphoramide combined with pentoxifylline for advanced breast cancer. ( Cap, B; Dezube, BJ; Hayes, DF; Henderson, IC; Shapiro, CL; Tretyakov, O; Wright, J, 1995) |
| "ThioTEPA was administered i." | 2.67 | Phase I/pharmacokinetic reevaluation of thioTEPA. ( Cole, D; DeLap, RJ; DeVito, J; Engstrom, PF; LaCreta, F; Litwin, S; O'Dwyer, PJ; Peter, R; Poplack, D; Tartaglia, L, 1991) |
| "One patient had a retinal vein thrombosis." | 2.39 | Hemolytic uremic syndrome after high dose chemotherapy with autologous stem cell support. ( Baars, JW; de Glas-Vos, CW; Rodenhuis, S; Thomas, BL; van der Lelie, H; van Dijk, MA; van Oers, RH; von dem Borne, AE, 1995) |
| "Thirty-five patients with advanced gynecologic malignancies were entered into a phase I study evaluating thio-TEPA in combination with cisplatin (50 mg/m2) intravenously every 4 weeks." | 1.28 | Phase I evaluation of thio-TEPA in combination with cisplatin for advanced gynecologic malignancies. ( Edwards, CL; Freedman, RS; Kavanagh, J; Raber, MN; Sandles, LG; Scott, WR; Wharton, JT, 1990) |
| "Thiotepa treatments should be limited to 90 mg/mo and protracted therapy avoided in elderly men." | 1.26 | Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma. ( Coleman, M; Hollister, D, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (50.00) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Wada, F | 1 |
| Nishikori, M | 1 |
| Hishizawa, M | 1 |
| Watanabe, M | 1 |
| Aiba, A | 1 |
| Kitano, T | 1 |
| Shimazu, Y | 1 |
| Shindo, T | 1 |
| Kondo, T | 1 |
| Takaori-Kondo, A | 1 |
| Ferreri, AJ | 1 |
| Cwynarski, K | 1 |
| Pulczynski, E | 1 |
| Ponzoni, M | 1 |
| Deckert, M | 1 |
| Politi, LS | 1 |
| Torri, V | 1 |
| Fox, CP | 1 |
| Rosée, PL | 1 |
| Schorb, E | 1 |
| Ambrosetti, A | 1 |
| Roth, A | 1 |
| Hemmaway, C | 1 |
| Ferrari, A | 1 |
| Linton, KM | 1 |
| Rudà, R | 1 |
| Binder, M | 1 |
| Pukrop, T | 1 |
| Balzarotti, M | 1 |
| Fabbri, A | 1 |
| Johnson, P | 1 |
| Gørløv, JS | 1 |
| Hess, G | 1 |
| Panse, J | 1 |
| Pisani, F | 1 |
| Tucci, A | 1 |
| Stilgenbauer, S | 1 |
| Hertenstein, B | 1 |
| Keller, U | 1 |
| Krause, SW | 1 |
| Levis, A | 1 |
| Schmoll, HJ | 1 |
| Cavalli, F | 1 |
| Finke, J | 1 |
| Reni, M | 1 |
| Zucca, E | 1 |
| Illerhaus, G | 1 |
| Minichmayr, I | 1 |
| Nock, V | 1 |
| Jaehde, U | 1 |
| Kloft, C | 1 |
| Schuster, MW | 1 |
| Beveridge, R | 1 |
| Frei-Lahr, D | 1 |
| Abboud, CN | 1 |
| Cruickshank, S | 1 |
| Macri, M | 1 |
| Menchaca, D | 1 |
| Holden, J | 1 |
| Waller, EK | 1 |
| Valteau-Couanet, D | 1 |
| Fillipini, B | 1 |
| Benhamou, E | 1 |
| Grill, J | 1 |
| Kalifa, C | 1 |
| Couanet, D | 1 |
| Habrand, JL | 1 |
| Hartmann, O | 1 |
| Soloway, MS | 1 |
| Ford, KS | 1 |
| Hollister, D | 1 |
| Coleman, M | 1 |
| Williams, SF | 1 |
| Lee, WJ | 1 |
| Bender, JG | 1 |
| Zimmerman, T | 1 |
| Swinney, P | 1 |
| Blake, M | 1 |
| Carreon, J | 1 |
| Schilling, M | 1 |
| Smith, S | 1 |
| Williams, DE | 1 |
| Oldham, F | 1 |
| Van Epps, D | 1 |
| van der Lelie, H | 1 |
| Baars, JW | 1 |
| Rodenhuis, S | 1 |
| van Dijk, MA | 1 |
| de Glas-Vos, CW | 1 |
| Thomas, BL | 1 |
| van Oers, RH | 1 |
| von dem Borne, AE | 1 |
| Hara, J | 1 |
| Osugi, Y | 1 |
| Ohta, H | 1 |
| Matsuda, Y | 1 |
| Nakanishi, K | 1 |
| Takai, K | 1 |
| Fujisaki, H | 1 |
| Tokimasa, S | 1 |
| Fukuzawa, M | 1 |
| Okada, A | 1 |
| Okada, S | 1 |
| Shapiro, CL | 1 |
| Dezube, BJ | 1 |
| Tretyakov, O | 1 |
| Wright, J | 1 |
| Cap, B | 1 |
| Henderson, IC | 1 |
| Hayes, DF | 1 |
| Torretta, L | 1 |
| Perotti, C | 1 |
| Pedrazzoli, P | 1 |
| Dornini, G | 1 |
| Viarengo, G | 1 |
| Livraghi, A | 1 |
| Noris, P | 1 |
| Da Prada, GA | 1 |
| Balduini, CL | 1 |
| della Cuna, GR | 1 |
| Salvaneschi, L | 1 |
| Prince, HM | 1 |
| Rischin, D | 1 |
| Toner, GC | 1 |
| Seymour, JF | 1 |
| Blakey, D | 1 |
| Gates, P | 1 |
| Eerhard, S | 1 |
| Chapple, P | 1 |
| Quinn, M | 1 |
| Brettell, M | 1 |
| Juneja, S | 1 |
| Wolf, M | 1 |
| Januszewicz, EH | 1 |
| Richardson, G | 1 |
| Scarlett, J | 1 |
| Briggs, P | 1 |
| Rampal, M | 1 |
| Alimi, JC | 1 |
| Pons, G | 1 |
| Fiquet, JM | 1 |
| O'Dwyer, PJ | 2 |
| LaCreta, F | 1 |
| Engstrom, PF | 1 |
| Peter, R | 1 |
| Tartaglia, L | 1 |
| Cole, D | 1 |
| Litwin, S | 1 |
| DeVito, J | 1 |
| Poplack, D | 1 |
| DeLap, RJ | 1 |
| Langer, CJ | 1 |
| Nash, S | 1 |
| Catalano, R | 1 |
| Rosenblum, NG | 1 |
| Hogan, WM | 1 |
| Comis, RL | 1 |
| Sandles, LG | 1 |
| Freedman, RS | 1 |
| Raber, MN | 1 |
| Kavanagh, J | 1 |
| Edwards, CL | 1 |
| Scott, WR | 1 |
| Wharton, JT | 1 |
| Mukaiyama, T | 1 |
| Ogawa, M | 1 |
| Horikoshi, N | 1 |
| Inoue, K | 1 |
| Fukutani, H | 1 |
| Tabata, M | 1 |
| Hirano, A | 1 |
| Mizunuma, N | 1 |
| Itami, S | 1 |
| Lokich, JJ | 1 |
| Egorin, MJ | 1 |
| Cohen, BE | 1 |
| Bern, MM | 1 |
| Zipoli, TE | 1 |
| Moore, C | 1 |
| Skeel, RT | 1 |
| Andersen, JW | 1 |
| Tormey, DC | 1 |
| Benson, AB | 1 |
| Asbury, RF | 1 |
| Falkson, G | 1 |
| Veenema, RJ | 1 |
| Romas, NA | 1 |
| Fingerhut, B | 1 |
| Shuvaeva, NI | 1 |
| Emel'ianova, LS | 1 |
| des Roseaux, M | 1 |
| Vacant, J | 1 |
| Beurton, D | 1 |
| Cukier, J | 1 |
| Archimbaud, JP | 1 |
| Calcat, P | 1 |
| Martel, JP | 1 |
| Oravisto, KJ | 1 |
| Livshits, MA | 1 |
| Chernyĭ, VA | 1 |
| Smirnova, IN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Phase II Trial On Primary Chemotherapy With High-Dose Methotrexate And High-Dose Cytarabine With Or Without Thiotepa, And With Or Without Rituximab, Followed By Brain Irradiation Vs. High-Dose Chemotherapy Supported By Autologous Stem Cells Tra[NCT01011920] | Phase 2 | 126 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thiotepa and Thrombopenia
| Article | Year |
|---|---|
Hemolytic uremic syndrome after high dose chemotherapy with autologous stem cell support.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; An | 1995 |
Chemotherapy for bladder cancer.
Topics: Administration, Topical; Alkylating Agents; Blood Cell Count; Carcinoma, Papillary; Cystitis; Cystos | 1974 |
8 trials available for thiotepa and Thrombopenia
| Article | Year |
|---|---|
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Topics: Acute Kidney Injury; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System | 2016 |
The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Bone Marrow Transplantation; | 2002 |
High-dose busulfan and thiotepa followed by autologous stem cell transplantation (ASCT) in previously irradiated medulloblastoma patients: high toxicity and lack of efficacy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; Child, Preschool; Combi | 2005 |
Selection and expansion of peripheral blood CD34+ cells in autologous stem cell transplantation for breast cancer.
Topics: Adult; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin | 1996 |
Dose escalation of N,N',N"-triethylenethiophosphoramide combined with pentoxifylline for advanced breast cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Dose-Response Relationship, Dr | 1995 |
Repetitive high-dose therapy with cyclophosphamide, thiotepa and docetaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer: results of a phase I study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Diarrhea; | 2000 |
Phase I/pharmacokinetic reevaluation of thioTEPA.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Leukocyte Count; Leukopenia; Male | 1991 |
Phase II trial of thio-TEPA in relapsed and refractory ovarian carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Agranulocytosis; Carcinoma, Squamous Cell; Drug Evaluation; Female; Hum | 1991 |
18 other studies available for thiotepa and Thrombopenia
| Article | Year |
|---|---|
Secondary failure of platelet recovery in patients treated with high-dose thiotepa and busulfan followed by autologous stem cell transplantation.
Topics: Adult; Aged; Busulfan; Central Nervous System Neoplasms; Female; Hematopoietic Stem Cell Transplanta | 2020 |
Thrombocytopenia following high-dose chemotherapy with carboplatin, etoposide and thiotepa in patients with testicular germ cell cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Etoposide; Humans; Male; Neoplas | 2013 |
Thiotepa-induced myelosuppression: review of 670 bladder instillations.
Topics: Adult; Aged; Female; Humans; Leukopenia; Male; Middle Aged; Thiotepa; Thrombocytopenia; Urinary Blad | 1983 |
Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma.
Topics: Adult; Aged; Anemia; Blood Cell Count; Bone Marrow; Female; Hematologic Diseases; Humans; Injections | 1980 |
Double-conditioning regimens consisting of thiotepa, melphalan and busulfan with stem cell rescue for the treatment of pediatric solid tumors.
Topics: Adolescent; Adult; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; | 1998 |
Autologous platelet collection and storage to support thrombocytopenia in patients undergoing high-dose chemotherapy and circulating progenitor cell transplantation for high-risk breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Blood Preservation; Blood Transfusi | 1998 |
[The harmfulness of intravesical instillations of thiotepa in cases of vesico-renal reflux].
Topics: Aged; Carcinoma, Transitional Cell; Humans; Leukopenia; Male; Thiotepa; Thrombocytopenia; Urinary Bl | 1978 |
Phase I evaluation of thio-TEPA in combination with cisplatin for advanced gynecologic malignancies.
Topics: Agranulocytosis; Anemia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; | 1990 |
[A study to overcome drug resistance using high-dose chemotherapy with autologous bone marrow transplantation].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Colony-Stimulati | 1989 |
A phase I study of thiotepa administered by short-term and protracted continuous intravenous infusion.
Topics: Adult; Aged; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leukocyte Count; | 1989 |
Combination chemotherapy of advanced breast cancer. Comparison of dibromodulcitol, doxorubicin, vincristine, and fluoxymesterone to thiotepa, doxorubicin, vinblastine, and fluoxymesterone: an Eastern Cooperative Oncology Group Study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; | 1989 |
[Toxic reactions during treatment of the ovarian cancer with ThioTEPA].
Topics: Animals; Blood Cell Count; Dyspepsia; Female; Leukopenia; Ovarian Neoplasms; Thiotepa; Thrombocytope | 1974 |
[Usual harmlessness of endovesical instillations of thio-tepa].
Topics: Carcinoma, Papillary; Electrocoagulation; Humans; Leukopenia; Papilloma; Thiotepa; Thrombocytopenia; | 1973 |
[Spontaneously cured pancytopenia due to intravesical thio-tepa, apropos of one case].
Topics: Anemia; Female; Herpes Zoster; Humans; Leukopenia; Middle Aged; Mucous Membrane; Papilloma; Thiotepa | 1973 |
Optimal intravesical dosage of thio-tepa in the prophylaxis of recurrent bladder papillomatosis.
Topics: Administration, Oral; Cystoscopy; Humans; Injections; Leukopenia; Neoplasm Recurrence, Local; Papill | 1972 |
[On quantitative changes in the leukocytes and thrombocytes after chemotherapy in patients with malignant tumors of the ovaries].
Topics: Antineoplastic Agents; Cyclophosphamide; Female; Humans; Leukopenia; Ovarian Neoplasms; Pyrimidines; | 1966 |
[The morphologic composition of peripheral blood following intra-arterial infusion of 5-fluorouracil and alkylating preparations in stomach cancer patients].
Topics: Anemia; Fluorouracil; Humans; Leukopenia; Melphalan; Nitrogen Mustard Compounds; Stomach Neoplasms; | 1970 |
[Results of treatment of tonsillar tumors by olivomycin].
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Chlorpromazine; Cyclophosp | 1969 |