thiotepa has been researched along with Spinal Cord Neoplasms in 3 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Spinal Cord Neoplasms: Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between April 1986 and March 1989, ten patients under 21 years of age with histologically confirmed malignant astrocytoma, received marrow-ablative chemotherapy with either thiotepa and Etoposide (five patients) or thiotepa, Etoposide and BCNU (five patients), followed by bone marrow 'rescue'." | 5.06 | High-dose multi-agent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence. ( August, C; Bayever, E; Finlay, JL; Freid, A; Kamani, N; Kramer, E; Packer, R; Rorke, L; Sutton, L; Zimmerman, R, 1990) |
| "Twelve had Burkitt's leukemia/lymphoma." | 2.39 | Excessive spinal cord toxicity from intensive central nervous system-directed therapies. ( Frierdich, S; Lee, Y; Moertel, CL; Morse, M; Nieder, M; Priest, JR; Toogood, I; Watterson, J, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thorarinsdottir, HK | 1 |
| Rood, B | 1 |
| Kamani, N | 2 |
| Lafond, D | 1 |
| Perez-Albuerne, E | 1 |
| Loechelt, B | 1 |
| Packer, RJ | 1 |
| MacDonald, TJ | 1 |
| Watterson, J | 1 |
| Toogood, I | 1 |
| Nieder, M | 1 |
| Morse, M | 1 |
| Frierdich, S | 1 |
| Lee, Y | 1 |
| Moertel, CL | 1 |
| Priest, JR | 1 |
| Finlay, JL | 1 |
| August, C | 1 |
| Packer, R | 1 |
| Zimmerman, R | 1 |
| Sutton, L | 1 |
| Freid, A | 1 |
| Rorke, L | 1 |
| Bayever, E | 1 |
| Kramer, E | 1 |
1 review available for thiotepa and Spinal Cord Neoplasms
| Article | Year |
|---|---|
Excessive spinal cord toxicity from intensive central nervous system-directed therapies.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, P | 1994 |
1 trial available for thiotepa and Spinal Cord Neoplasms
| Article | Year |
|---|---|
High-dose multi-agent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bone Marrow Transplantation | 1990 |
1 other study available for thiotepa and Spinal Cord Neoplasms
| Article | Year |
|---|---|
Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child, Preschool; Cisp | 2007 |