Page last updated: 2024-11-05

thiotepa and Rheumatoid Arthritis

thiotepa has been researched along with Rheumatoid Arthritis in 26 studies

Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

Research Excerpts

Excerpt	Relevance	Reference
"Rheumatoid arthritis was the most common underlying disease, in addition to giant cell arteritis, polyarteritis nodosa, chronic glomerulonephritis, and scleroderma."	1.26	Acute nonlymphocytic leukemia in patients receiving chemotherapy for nonmalignant diseases. ( Bukowski, RM; Hoffman, GC; Savage, RA; Sebek, BA; Sheibani, K; Tubbs, RR, 1980)

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (96.15)	18.7374
1990's	1 (3.85)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
FLATT, AE	1
WENLEY, WG	1
GLICK, EN	1
FEARNLEY, ME	1
HOWES, RG	2
JARVIS, B	1
Pincus, T	1
Callahan, LF	1
Sale, WG	1
Brooks, AL	1
Payne, LE	1
Vaughn, WK	1
Sheibani, K	1
Bukowski, RM	1
Tubbs, RR	1
Savage, RA	1
Sebek, BA	1
Hoffman, GC	1
Pardini Júnior, AG	1
Akel, AN	1
Menkes, CJ	1
Decker, JL	1
Healey, LA	1
Venenson, EV	1
Currey, HL	1
Kogstad, O	1
Zuckner, J	1
Uddin, J	1
Ramsey, RH	1
Gantner, GE	1
Ahern, AM	1
Dorner, RW	2
Langkilde, M	1
Rossel, I	1
Elstein, D	1
Isdale, IC	1
Rose, BS	1
Conlon, PW	1
Gross, D	3
Enderlin, M	2
Fehr, K	1
Llopis Faner, B	1
Morandi, GA	1
Andreotti, L	1
Frosecchi, M	1
Del Mela, P	1
Deicher, H	2
Fricke, R	2
Krull, P	1
Gristina, AG	1
Pace, NA	1
Kantor, TG	1
Thompson, WA	1
Kruli, P	1

Clinical Trials (2)

Trial Overview

Trial	Enrollment	Study Type	Start Date	Status
The Use of a Health Management Tool in a Clinic Setting to Improve Self-Efficacy in Rheumatoid Arthritis Patients: a Randomized Clinical Trial.[NCT01913080]	67 participants (Actual)	Interventional	2013-09-30	Completed
Rheumatoid Arthritis Patient-to-Patient Connection Program[NCT01525654]	65 participants (Actual)	Interventional	2009-03-31	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for thiotepa and Rheumatoid Arthritis

Article	Year
[Immunosuppresive therapy of progredient chronic polyarthritis using antimetabolites and cytostatics]. Schweizerische medizinische Wochenschrift, 1967, Oct-07, Volume: 97, Issue:40 Topics: Adrenal Cortex Hormones; Antigen-Antibody Reactions; Antimetabolites; Antineoplastic Agents; Arthrit	1967
[Treatment of chronic diseases of connective tissue by cytostatic drugs]. Revista clinica espanola, 1970, Volume: 116, Issue:6 Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Female; Huma	1970

Trials

2 trials available for thiotepa and Rheumatoid Arthritis

Article	Year
Is there a place for chemical and radiation synovectomy in rheumatic diseases? Rheumatology and rehabilitation, 1979, Volume: 18, Issue:2 Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Erbium; Gold Colloid, Radioact	1979
Evaluation of intra-articular thio-tepa in rheumatoid arthritis. Annals of the rheumatic diseases, 1966, Volume: 25, Issue:2 Topics: Arthritis, Rheumatoid; Chemistry Techniques, Analytical; Clinical Trials as Topic; Humans; Hydrocort	1966

Other Studies

22 other studies available for thiotepa and Rheumatoid Arthritis

Article	Year
Intraarticular Thio-tepa in rheumatoid disease of the hands. Rheumatism, 1962, Volume: 18 Topics: Arthritis; Arthritis, Rheumatoid; Hand; Humans; Thiotepa	1962
MEDICAL SYNOVECTOMY WITH THIOTEPA. Annals of physical medicine, 1964, Volume: 8 Topics: Arthritis; Arthritis, Rheumatoid; Drug Therapy; Humans; Hydrocortisone; Injections; Injections, Intr	1964
INTRA-ARTICULAR THIOTEPA THERAPY IN RHEUMATOID ARTHRITIS. Annals of physical medicine, 1964, Volume: 8 Topics: Arthritis; Arthritis, Rheumatoid; Drug Therapy; Humans; Injections; Injections, Intra-Articular; Met	1964
THE EFFECTS OF INTRA-ARTICULAR THIOTEPA ON SYNOVIAL FLUIDS. Arthritis and rheumatism, 1965, Volume: 8 Topics: Arthritis; Arthritis, Rheumatoid; Blood Cell Count; Blood Proteins; Drug Therapy; Electrophoresis; H	1965
Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis and rheumatism, 1984, Volume: 27, Issue:8 Topics: Activities of Daily Living; Adult; Aged; Arthritis, Rheumatoid; Disability Evaluation; Female; Human	1984
Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis and rheumatism, 1984, Volume: 27, Issue:8 Topics: Activities of Daily Living; Adult; Aged; Arthritis, Rheumatoid; Disability Evaluation; Female; Human	1984
Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis and rheumatism, 1984, Volume: 27, Issue:8 Topics: Activities of Daily Living; Adult; Aged; Arthritis, Rheumatoid; Disability Evaluation; Female; Human	1984
Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis and rheumatism, 1984, Volume: 27, Issue:8 Topics: Activities of Daily Living; Adult; Aged; Arthritis, Rheumatoid; Disability Evaluation; Female; Human	1984
Acute nonlymphocytic leukemia in patients receiving chemotherapy for nonmalignant diseases. Human pathology, 1980, Volume: 11, Issue:2 Topics: Arthritis, Rheumatoid; Chromosomes; Drug Therapy, Combination; Drug-Related Side Effects and Adverse	1980
Intra-articular injection of thiotepa in the treatment of rheumatoid arthritis of the digital joints. The Journal of hand surgery, 1995, Volume: 20, Issue:3 Pt 2 Topics: Arthritis, Rheumatoid; Female; Finger Joint; Follow-Up Studies; Humans; Injections, Intra-Articular;	1995
Editorial: Medical synovectomy. Lancet (London, England), 1974, Mar-02, Volume: 1, Issue:7853 Topics: Arthritis, Rheumatoid; Gold Colloid, Radioactive; Humans; Injections, Intra-Articular; Nitrogen Must	1974
When to use cytotoxic drugs in rheumatoid arthritis. Geriatrics, 1973, Volume: 28, Issue:6 Topics: Antigen-Antibody Complex; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil;	1973
[Mechanism of action of cytostatic agents in rheumatoid arthritis]. Terapevticheskii arkhiv, 1974, Volume: 46, Issue:1 Topics: Adult; Antibodies; Antineoplastic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Chlorambucil;	1974
Intra-articular thiotepa in rheumatoid arthritis. Annals of the rheumatic diseases, 1965, Volume: 24, Issue:4 Topics: Arthritis, Rheumatoid; Fingers; Humans; Immunoelectrophoresis; In Vitro Techniques; Injections, Intr	1965
Baker's cyst. Acta rheumatologica Scandinavica, 1965, Volume: 11, Issue:3 Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Diagnosis, Di	1965
Intra-articular use of cytostatica. (Thio-Tepa, Azetepa and Osmium acid). Acta rheumatologica Scandinavica, 1967, Volume: 13, Issue:2 Topics: Adolescent; Adult; Aged; Alkylating Agents; Arthritis, Rheumatoid; Aziridines; Azirines; Female; Hum	1967
Treatment of rheumatoid arthritis. Chemical and surgical synovectomy. Minnesota medicine, 1966, Volume: 49, Issue:12 Topics: Arthritis, Rheumatoid; Humans; Synovectomy; Thiotepa	1966
Experiences with intra-articular thiotepa in rheumatoid arthritis. The New Zealand medical journal, 1967, Volume: 66, Issue:422 Topics: Arthritis, Rheumatoid; Bone Marrow; Female; Follow-Up Studies; Humans; Injections, Intra-Articular;	1967
[Our 1st experiences with the intra-articular use of ethylamines and other alkylating agents]. Revista espanola de reumatismo y enfermedades osteoarticulares, 1966, Volume: 11, Issue:8 Topics: Arthritis, Rheumatoid; Cyclophosphamide; Female; Humans; Male; Thiotepa	1966
[Contribution on the therapy of progressive chronic polyarthritis with antimetabolites and cytostatics]. Zeitschrift fur Rheumaforschung, 1967, Volume: 26, Issue:1 Topics: Adolescent; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Betamethaso	1967
[Intra-articular thio-tepa in the treatment of rheumatoid arthritis]. Rivista critica di clinica medica, 1968, Volume: 68, Issue:3 Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Injections, Intra-Articular; Male; Methylprednis	1968
[Treatment of chronic connective tissue diseases with cytostatics]. Minerva medica, 1970, Jul-11, Volume: 61, Issue:55 Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Chronic Disease; Collagen	1970
Intra-articular thio-tepa compared with depomedrol and procaine in the treatment of arthritis. The Journal of bone and joint surgery. American volume, 1970, Volume: 52, Issue:8 Topics: Animals; Arthritis, Rheumatoid; Female; Humans; Injections, Intra-Articular; Male; Methylprednisolon	1970
Effect of nitrogen mustard on hyaluronate. Biochemical pharmacology, 1969, Volume: 18, Issue:10 Topics: Arthritis, Rheumatoid; Chemical Phenomena; Chemistry; Chemistry, Physical; Chromatography, Gel; Dial	1969
[Intra-articular treatment of progressive chronic polyarthritis with cytostatic agents (thio-tepa)]. Helvetica medica acta. Supplementum, 1966, May-15, Volume: 46 Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Chronic Disease; Humans; Injections, Intra-Articular;	1966