thiotepa has been researched along with Pterygium in 30 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Pterygium: An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea, being immovably united to the cornea at its apex, firmly attached to the sclera throughout its middle portion, and merged with the conjunctiva at its base. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Topical Mitomycin caused: iritis, conjunctival irritation, excessive lacrymation, photophobia, ocular pain; Thio-tepa caused: photophobia, foreign body sensation, headache." | 9.08 | [A comparative study of thio-tepa and mitomycin C in the treatment of pterygium. Preliminary results]. ( Kayembe, L; Ngoy, D, 1998) |
| "To evaluate the efficiency of Cyclosporine A and Thiotepa to decrease the postoperative recurrence rate of pterygium." | 7.70 | [Cyclosporine A and thiotepa in prevention of postoperative recurrence of pterygium]. ( Chen, G; Wu, H, 1999) |
| "To analyze effectiveness and side effects of thiotepa eyedrops utilized to prevent postoperative pterygium recurrence, with a retrospective study allowing a long follow-up." | 7.70 | [Thiotepa eyedrops for prevention of pterygium recurrence: 18 years of use]. ( Ribe, D; Tassy, A, 1999) |
| " Topical Mitomycin caused: iritis, conjunctival irritation, excessive lacrymation, photophobia, ocular pain; Thio-tepa caused: photophobia, foreign body sensation, headache." | 5.08 | [A comparative study of thio-tepa and mitomycin C in the treatment of pterygium. Preliminary results]. ( Kayembe, L; Ngoy, D, 1998) |
| "To analyze effectiveness and side effects of thiotepa eyedrops utilized to prevent postoperative pterygium recurrence, with a retrospective study allowing a long follow-up." | 3.70 | [Thiotepa eyedrops for prevention of pterygium recurrence: 18 years of use]. ( Ribe, D; Tassy, A, 1999) |
| "Pterygium excision was complicated by bacterial corneoscleritis and endophthalmitis in two patients, one who had received postoperative beta irradiation and the other topical thiotepa." | 3.67 | Bacterial corneoscleritis complicating pterygium excision. ( Farrell, PL; Smith, RE, 1989) |
| " When beta-radiation or Thiotepa is used there is a general consensus on the dosage for each of these." | 1.28 | Treatment of pterygia in Queensland. ( Hirst, LW; Sebban, A, 1991) |
| "The difference in the recurrence rate between the eyes submitted to Beta therapy and those not submitted is considered statistically significant." | 1.27 | Pterygium and beta irradiation. ( Barishak, YR; Monselise, M; Politi, F; Schwartz, M, 1984) |
| "Guidelines for the treatment of pterygium are recommended." | 1.26 | The management of pterygium. ( Ehrlich, D, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (80.00) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 1 (3.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harrison, M | 2 |
| Wu, H | 1 |
| Chen, G | 1 |
| MEACHAM, CT | 2 |
| WESSON, TW | 1 |
| PETTIS, JL | 1 |
| Cassady, JR | 1 |
| Liddy, BS | 1 |
| Morgan, JF | 1 |
| Joselson, GA | 1 |
| Muller, P | 1 |
| Gourcuff, A | 1 |
| Tassy, A | 2 |
| Garron, J | 1 |
| Perruchot, PJ | 1 |
| Blondel, P | 1 |
| Monselise, M | 1 |
| Schwartz, M | 1 |
| Politi, F | 1 |
| Barishak, YR | 1 |
| Ngoy, D | 1 |
| Kayembe, L | 1 |
| Ribe, D | 1 |
| Olander, K | 1 |
| Haik, KG | 1 |
| Haik, GM | 1 |
| Ehrlich, D | 1 |
| Chapman-Smith, JS | 1 |
| Sebban, A | 1 |
| Hirst, LW | 1 |
| Farrell, PL | 1 |
| Smith, RE | 1 |
| Kleis, W | 1 |
| Picó, G | 1 |
| Colvin, C | 1 |
| Hornblass, A | 1 |
| Adler, RI | 1 |
| Vukcevich, WM | 1 |
| Gombos, GM | 1 |
| Choon, LK | 1 |
| Asregadoo, ER | 1 |
| Cooper, JC | 1 |
| Vitali, G | 1 |
| Portney, GL | 1 |
| Allende, FP | 1 |
| Howitt, D | 1 |
| Karp, EJ | 1 |
| Chervin, M | 1 |
| Vaccaro, GL | 1 |
| De Vecchi, HP | 1 |
| Kelly, A | 1 |
| Ohlrich, J | 1 |
| Whaites, JM | 1 |
2 reviews available for thiotepa and Pterygium
| Article | Year |
|---|---|
The inhibition of pterygium recurrence by thio-tepa.
Topics: Animals; Antineoplastic Agents, Alkylating; Humans; Ophthalmologic Surgical Procedures; Postoperativ | 1966 |
Management of pterygia: should thiotepa be used?
Topics: Animals; Humans; Pigmentation Disorders; Pterygium; Recurrence; Sunlight; Thiotepa | 1978 |
2 trials available for thiotepa and Pterygium
| Article | Year |
|---|---|
[A comparative study of thio-tepa and mitomycin C in the treatment of pterygium. Preliminary results].
Topics: Administration, Topical; Adult; Aged; Alkylating Agents; Conjunctiva; Cost-Benefit Analysis; Drug Co | 1998 |
Pterygium: "thiotepa" versus beta radiation, a double-blind trial.
Topics: Clinical Trials as Topic; Eye; Humans; Placebos; Pterygium; Radiation Effects; Thiotepa | 1969 |
26 other studies available for thiotepa and Pterygium
| Article | Year |
|---|---|
Cost of pterygium.
Topics: Clinical Trials as Topic; Humans; Pterygium; Thiotepa | 2002 |
[Cyclosporine A and thiotepa in prevention of postoperative recurrence of pterygium].
Topics: Adult; Aged; Cyclosporine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Ophthalmic Solution | 1999 |
Triethylene thiophosphoramide in the prevention of pterygium recurrence.
Topics: Biomedical Research; Humans; Pterygium; Thiotepa | 1962 |
RECURRENT PTERYGIUM: USE OF TOPICAL TRIETHYLENE THIOPHOSPHORAMIDE.
Topics: Drug Therapy; Humans; Pterygium; Thiotepa | 1965 |
PREVENTION ON RECURRENCE OF PTERYGIUM.
Topics: Biomedical Research; Humans; Neoplasms; Preventive Medicine; Pterygium; Recurrence; Thiotepa | 1965 |
Triethylene thiophosphoramide (thio-tepa) and pterygium.
Topics: Antineoplastic Agents, Alkylating; Follow-Up Studies; Humans; Male; Ophthalmic Solutions; Ophthalmol | 1966 |
Incidence of pterygium recurrence in patients treated with thio-tepa.
Topics: Antineoplastic Agents, Alkylating; Follow-Up Studies; Humans; Incidence; Pterygium; Recurrence; Thio | 1966 |
[Thio-tepa eyedrops against recurrent pterygium and neovascularization of the cornea].
Topics: Cornea; Humans; Neovascularization, Pathologic; Ophthalmic Solutions; Postoperative Care; Pterygium; | 1984 |
Pterygium and beta irradiation.
Topics: Dexamethasone; Humans; Postoperative Complications; Pterygium; Recurrence; Thiotepa | 1984 |
[Thiotepa eyedrops for prevention of pterygium recurrence: 18 years of use].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Follow-Up Studies; Humans; Middle Aged; Ophth | 1999 |
The management of pterygium.
Topics: Administration, Topical; Anti-Inflammatory Agents; Glucocorticoids; Humans; Postoperative Complicati | 1977 |
Pterygium treatment with triethylene thiophosphoramide.
Topics: Adolescent; Adult; Aged; Female; Follow-Up Studies; Humans; Male; Middle Aged; Ophthalmic Solutions; | 1992 |
Treatment of pterygia in Queensland.
Topics: Australia; Beta Particles; Data Collection; Humans; Postoperative Complications; Pterygium; Recurren | 1991 |
Bacterial corneoscleritis complicating pterygium excision.
Topics: Adult; Aged; Beta Particles; Combined Modality Therapy; Endophthalmitis; Female; Humans; Keratitis; | 1989 |
Thio-TEPA therapy to prevent postoperative pterygium occurrence and neovascularization.
Topics: Follow-Up Studies; Humans; Ophthalmic Solutions; Postoperative Complications; Pterygium; Thiotepa | 1973 |
Treatment of pterygia with and without thiotepa.
Topics: Adult; Child; Female; Humans; Male; Methods; Postoperative Care; Pterygium; Thiotepa | 1973 |
A delayed side effect of topical thiotepa.
Topics: Administration, Topical; Eyelashes; Female; Histocytochemistry; Humans; Melanins; Middle Aged; Pigme | 1974 |
Topical thio-tipa in the prevention of pterygium recurrence after surgery.
Topics: Adult; Female; Humans; Male; Ophthalmologic Surgical Procedures; Pterygium; Thiotepa | 1969 |
Surgery, thio-tepa, and corticosteroid in the treatment of pterygium.
Topics: Dexamethasone; Follow-Up Studies; Humans; Pigmentation Disorders; Pterygium; Recurrence; Sunlight; T | 1972 |
Pterygium: prevention of recurrence by excision and postoperative thio-tepa.
Topics: Adult; Aged; Humans; Middle Aged; Pterygium; Thiotepa | 1966 |
[Recurrences of pterygium after treatment. Our results with the local use of an antimitotic drug].
Topics: Female; Humans; Male; Pterygium; Thiotepa | 1968 |
Bare sclera, scleral cautery and corticosteroid therapy of endemic pterygium in the Navajo Indian.
Topics: Arizona; Cautery; Disease Reservoirs; Eye Diseases; Follow-Up Studies; Humans; Indians, North Americ | 1969 |
[Prevention of recurrence in the pterygium operation by means of an antimitotic cytolytic collyrium with triethylenethiophosphoramide base (Thio-Tepa) used from the immediate postoperative period].
Topics: Humans; Pterygium; Thiotepa | 1969 |
Side-effect of topical Thio-tepa.
Topics: Adult; Eye Diseases; Eyelashes; Humans; Male; Pigmentation Disorders; Pterygium; Thiotepa | 1969 |
[Use of Thio-Tepa (thiethylene thiophosphoramide) in the postoperative period of pterygium. Personal experience in 71 eyes operated on during a period of more than 2 years of observation].
Topics: Humans; Postoperative Care; Pterygium; Thiotepa | 1969 |
The prevention of recurrent pterygia.
Topics: Humans; Pterygium; Suture Techniques; Thiotepa; Tropical Climate | 1971 |