thiotepa has been researched along with Pregnancy in 44 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chromosome aberrations were studied in cells of embryo liver of 101/H and CBA mice following mutagenic treatment with the alkylating agent--thiophosphamide." | 1.26 | [101/H line mice, a possible model of human chromosomal instability diseases]. ( Korogodina, IuV; S'iakste, TG, 1981) |
| "Chromosomal aberrations were studied in cells of embryonic liver and bone marrow of A/He and C57BL/6 mice following mutagenic treatment by the alkylating agent thiophosphamide in g1-S periods of the cell cycle." | 1.26 | [Thiophosphamide-induced chromosome aberrations in embryonal liver and bone marrow cells of A/He and C57BL/L mice]. ( Gordeeva, EV; Korogodina, IuV; Lil'p, IG, 1979) |
| "The contribution of induced chromosomal aberrations to preimplantation embryonic death was studied." | 1.26 | [Estimation of the contribution of thiophosphamide-induced chromosomal aberrations to perimplantation embryonic mortality in mice]. ( Malashenko, AM; Semenov, KhKh, 1979) |
| "Structure chromosome aberrations were found in the cells of such embryos." | 1.26 | [Mutagenic effect of chemical compounds on laboratory mice]. ( Malashenko, AM; Selezneva, GP; Semenov, KhKh; Surkova, NI, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (90.91) | 18.7374 |
| 1990's | 4 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| TEN BERGE, BS | 1 |
| NECHAEVA, ID | 1 |
| HRESCHCHYSHYN, MM | 1 |
| HART, LG | 1 |
| DIXON, RL | 1 |
| LONG, JP | 1 |
| MACKAY, B | 1 |
| NISHIKAWA, M | 1 |
| NANJO, H | 1 |
| Howe, GR | 1 |
| Steward, R | 1 |
| S'iakste, TG | 2 |
| S'iakste, NI | 1 |
| Likhtenshteĭn, AV | 1 |
| Fujii, T | 1 |
| Nakatsuka, T | 1 |
| Ambrossieva, ED | 1 |
| Korogodina, IuV | 3 |
| Kaurov, BA | 1 |
| Semenov, KhKh | 6 |
| Malashenko, AM | 6 |
| Ariyuki, F | 1 |
| Higaki, K | 1 |
| Yasuda, M | 2 |
| Dirven, HA | 1 |
| Dictus, EL | 1 |
| Broeders, NL | 1 |
| van Ommen, B | 1 |
| van Bladeren, PJ | 1 |
| Lil'p, IG | 3 |
| Bizikoeva, FZ | 1 |
| Poletaeva, II | 1 |
| Ivanov, VI | 1 |
| Llombart, A | 1 |
| Gordeeva, EV | 1 |
| Selezneva, GP | 1 |
| Surkova, NI | 1 |
| Khil'kevich, LV | 1 |
| Kurilo, LF | 1 |
| Zhubinskaia, VP | 1 |
| Krarup-Hansen, A | 2 |
| Lacher, MJ | 1 |
| Toner, K | 1 |
| Brok, KE | 2 |
| Elberg, JJ | 2 |
| Nishimura, H | 4 |
| Terada, M | 1 |
| Takano, K | 1 |
| Tanimura, T | 4 |
| Takino, T | 1 |
| Yamamura, H | 1 |
| Okada, T | 1 |
| Tanaka, T | 1 |
| Zipper, J | 1 |
| Medel, M | 1 |
| Prager, R | 1 |
| Hershberger, LG | 1 |
| Hansen, DM | 1 |
| Hansen, LM | 1 |
| Halbrecht, I | 1 |
| Komlos, L | 1 |
| Vasnetsova, SS | 1 |
| Bulkina, ZP | 1 |
| Turkevich, NM | 1 |
2 reviews available for thiotepa and Pregnancy
| Article | Year |
|---|---|
Tris (1-aziridinyl)phosphine sulphide.
Topics: Animals; Carcinogens; Drosophila melanogaster; Drug Evaluation, Preclinical; Female; Genes, Lethal; | 1975 |
Thiotepa.
Topics: Animals; Carcinogens; Female; Humans; Male; Molecular Structure; Pregnancy; Reproduction; Thiotepa | 1990 |
42 other studies available for thiotepa and Pregnancy
| Article | Year |
|---|---|
[A patient with choriocarcinoma after molar abortion & pulmonary metastases treated with x-rays & thio-TEPA].
Topics: Abortion, Induced; Abortion, Spontaneous; Animals; Antineoplastic Agents; Choriocarcinoma; Female; H | 1959 |
[DATA ON THE USE OF THIO-TEPA IN COMBINED TREATMENT OF PATIENTS WITH MALIGNANT OVARIAN TUMORS].
Topics: Adnexa Uteri; Choriocarcinoma; Cystadenoma; Cystadenoma, Mucinous; Dermoid Cyst; Female; Humans; Hys | 1963 |
EXPERIENCES WITH CHEMOTHERAPY IN GYNECOLOGIC CANCER.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Cyclophosphamide; Dactinomycin; Female; Ge | 1964 |
STUDIES USING CLOSTRIDIUM BOTULINUM TOXIN--TYPE A.
Topics: Acetylcholine; Antitoxins; Barbiturates; Botulinum Toxins; Brain Chemistry; Calcium; Chlorpromazine; | 1965 |
[TERATOGENIC EFFECT OF A COMBINATION OF FASTING AND THIO-TEPA ADMINISTRATION IN PREGNANT MICE].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Fasting; Female; Humans; Mice; Pharm | 1964 |
[MATERNAL AGE OF MICE AND THE ADMINISTRATION OF THIO-TEPA DURING PREGNANCY AS RELATED TO THE MALFORMATION OF THE FETUS].
Topics: Abnormalities, Drug-Induced; Aging; Animals; Female; Fetus; Humans; Maternal Age; Mice; Pharmacology | 1964 |
Fertility regulation in male rats and hamsters with alkylating agents.
Topics: Animals; Azirines; Contraceptive Agents, Male; Cricetinae; Female; Fertility; Injections; Litter Siz | 1980 |
[DNA and chromatin defects induced by thiophosphamide].
Topics: Animals; Cells, Cultured; Chromatin; DNA; Embryo, Mammalian; Female; Fibroblasts; Mice; Pregnancy; T | 1983 |
Potentiating effects of caffeine on teratogenicity of alkylating agents in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Alkylating Agents; Animals; Antibioti | 1983 |
Electrophoretic enzyme variants detected in F1 progeny of males treated by alkylating mutagen.
Topics: Animals; Crosses, Genetic; Female; Fetus; Gene Frequency; Genes, Dominant; Genes, Lethal; Genetic Va | 1984 |
[Teratogenic effect of thiophosphamide on mice of different genotypes].
Topics: Abnormalities, Drug-Induced; Animals; Female; Genotype; Mice; Mice, Inbred Strains; Pregnancy; Terat | 1984 |
[Preimplantation embryonic mortality--method of studying interstrain differences in the reparative activity of mouse ova].
Topics: Animals; DNA Repair; Embryonic Development; Female; Fetal Death; Genotype; Hybridization, Genetic; M | 1980 |
A study of fetal growth retardation in teratological tests: an examination of the relationship between body weight and ossification of coccygeal vertebrae in mouse and rat fetuses.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Animals; Body Weight; Coccyx; Female; Fetal Growth Retardation; | 1980 |
[Role of female genotype in manifestation of dominant lethal mutations induced by thiophosphamide in the spermatids of male rats].
Topics: Animals; Female; Fertilization; Fetal Death; Genes, Dominant; Genes, Lethal; Genotype; Male; Mice; M | 1980 |
[Demonstration of dominant lethal mutations in early mouse embryogenesis].
Topics: Animals; Blastocyst; Female; Fetal Death; Genes, Dominant; Genes, Lethal; Infertility, Male; Male; M | 1981 |
[101/H line mice, a possible model of human chromosomal instability diseases].
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Disease Models, Animal; Female; Fetal Death; | 1981 |
The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa.
Topics: Chromatography, High Pressure Liquid; Female; Glutathione; Glutathione Transferase; Humans; Isoenzym | 1995 |
[Behavior of adult mice of various strains after exposure of thiophosphamide during organogenesis].
Topics: Animals; Behavior, Animal; DNA Repair; Embryonic and Fetal Development; Female; Genotype; Male; Mice | 1995 |
Tumoral drugs as possible blastogenic agents the problem of anti-blastic medication.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinogens; Cyclophosphamide; Dactinomycin; Daunorubicin | 1976 |
[Thiophosphamide-induced chromosome aberrations in embryonal liver and bone marrow cells of A/He and C57BL/L mice].
Topics: Animals; Bone Marrow; Chromosome Aberrations; Embryo, Mammalian; Female; Liver; Male; Mice; Mice, In | 1979 |
[Estimation of the contribution of thiophosphamide-induced chromosomal aberrations to perimplantation embryonic mortality in mice].
Topics: Animals; Chromosome Aberrations; Embryo, Mammalian; Embryonic Development; Female; Fetal Death; Kary | 1979 |
[Chemotherapy of gynecologic tumors].
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cyclophosphamide; Female; Humans; Melphalan; Methotre | 1976 |
[Mutagenic effect of chemical compounds on laboratory mice].
Topics: Animals; Chromosome Aberrations; Embryonic Development; Female; Genes, Dominant; Genes, Lethal; Male | 1978 |
[Cytological study of early embryonic mortality in laboratory mice].
Topics: Animals; Animals, Laboratory; Chromosome Aberrations; Embryo Loss; Embryonic Development; Female; Fe | 1975 |
[Effect of antenatal action of Thio-Tepa on spermatogenesis of mature 101/N and CBA mice].
Topics: Age Factors; Animals; Female; Fetus; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Pregnancy; | 1992 |
[Teratogenic effect of thiotepa].
Topics: Adult; Female; Humans; Pregnancy; Teratogens; Thiotepa | 1989 |
Pregnancies and menstrual function before and after combined radiation (RT) and chemotherapy (TVPP) for Hodgkin's disease.
Topics: Adolescent; Adult; Age Factors; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Combined | 1986 |
[Teratogenic effect of thiotepa despite observation of safety regulations].
Topics: Adult; Antineoplastic Agents; Diaphragmatic Eventration; Diseases in Twins; Female; Humans; Infant, | 1988 |
[Teratogenic effect of thio-tepa despite use of safety rules].
Topics: Adult; Female; Humans; Infant, Newborn; Nurses; Occupational Diseases; Pregnancy; Teratogens; Thiote | 1988 |
[Teratogen effect of Thiotepa].
Topics: Female; Humans; Pregnancy; Teratogens; Thiotepa | 1988 |
Mitigated teratogenicity of thio-TEPA in goldthioglucose obese mice.
Topics: Abnormalities, Drug-Induced; Animals; Clubfoot; Female; Fingers; Glucose; Gold; Mice; Obesity; Pregn | 1967 |
The susceptibility of the offspring of alloxandiabetic mice to a teratogen.
Topics: Abnormalities, Drug-Induced; Animals; Diabetes Mellitus, Experimental; Female; Fetus; Maternal-Fetal | 1965 |
Modification of the teratogenic effect of thio-TEPA on the mouse offspring by successive maternal treatment with tolbutamide.
Topics: Abnormalities, Drug-Induced; Animals; Female; Mice; Pregnancy; Thiotepa; Tolbutamide | 1966 |
[Effect of thio-TEPA on the forelimb buds of the mouse embryo in vitro].
Topics: Abnormalities, Drug-Induced; Animals; Cartilage; Extremities; Female; In Vitro Techniques; Male; Mes | 1966 |
[Postnatal fate of mice subjected to thio-TEPA during the embryonic stage].
Topics: Abnormalities, Drug-Induced; Animals; Female; Male; Mice; Pregnancy; Thiotepa | 1967 |
Alterations in fertility induced by unilateral intrauterine instillation of cytotoxic compounds in rats.
Topics: Animals; Cadmium; Colchicine; Endometrium; Ethanol; Female; Fertility; Humans; Iodoacetates; Plants, | 1968 |
Relationship of dosage and time of administration to the teratogenic effects of thio-TEPA in mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Maternal-Fetal Exchange; Mice; Placenta; Pregnancy; Pr | 1968 |
Cytotoxic agents in the treatment of malignant disease.
Topics: Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Chlorambucil; Choriocarcinoma; | 1968 |
Modification of the teratogenic effects of certain antineoplastic agents by combined treatment with vitamins.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Drug Antagonism; Drug Synergism; Female; Fetal De | 1968 |
Effects of antifertility agents on male mice as determined by a serial mating method.
Topics: Amines; Animals; Female; Fertility; Male; Mice; Nitrofurazone; Pregnancy; Pyrrolidines; Thiotepa | 1969 |
Cytotoxic effects of various sera on primary cultures of placentas and ovarian tumors.
Topics: Adenocarcinoma; Ascitic Fluid; Blood; Culture Techniques; Cytotoxicity Tests, Immunologic; Female; H | 1971 |
[Effect of antineoplastic agents on the hypophysis-ovarian system in rats with transplantable mammary neoplasms].
Topics: Adrenal Glands; Animals; Cyclophosphamide; Estrus; Female; Fluorouracil; Mammary Neoplasms, Experime | 1971 |