thiotepa has been researched along with Peritoneal Carcinomatosis in 13 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| " With this rationale a clinical phase I and pharmacokinetic study of intraperitoneally administered N, N', N'' triethylenethiophosphoramide (thiotepa), an alkylating agent with activity against ovarian carcinoma, was initiated with the objectives of determining the systemic and local toxicities, maximum-tolerated dose, and pharmacokinetic advantage associated with using the drug in this manner." | 1.28 | Phase I clinical and pharmacokinetic study of thiotepa administered intraperitoneally in patients with advanced malignancies. ( Egorin, MJ; Runowicz, CD; Salva, K; Tortorello, L; Wadler, S; Wiernik, PH; Zuhowski, EG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| NECHAEVA, ID | 1 |
| Vinokurov, VL | 1 |
| Mitrokhina, MV | 1 |
| Spratt, JS | 1 |
| Adcock, RA | 1 |
| Muskovin, M | 1 |
| Sherrill, W | 1 |
| McKeown, J | 1 |
| Irzhanov, SI | 1 |
| Serov, SF | 1 |
| Brenner, J | 1 |
| Sordillo, PP | 1 |
| Magill, GB | 1 |
| Legha, SS | 1 |
| Muggia, FM | 1 |
| Chauffert, B | 1 |
| Dimanche-Boitrel, MT | 1 |
| Genne, P | 1 |
| Petit, JM | 1 |
| Onier, N | 1 |
| Jeannin, JF | 1 |
| Wadler, S | 1 |
| Egorin, MJ | 1 |
| Zuhowski, EG | 1 |
| Tortorello, L | 1 |
| Salva, K | 1 |
| Runowicz, CD | 1 |
| Wiernik, PH | 1 |
| Schwandt, P | 1 |
| Ehrhart, H | 1 |
| Magell, J | 1 |
| Limber, GK | 1 |
| King, RE | 1 |
| Silverberg, SG | 1 |
| Gerner, RE | 1 |
| Moore, GE | 1 |
| Maliugina, LL | 1 |
| Pol'kina, RI | 1 |
| Remizov, AL | 1 |
| Petrov, AS | 1 |
| Kraĭz, BO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| BEV-IP: Perioperative Chemotherapy With Bevacizumab in Patients Undergoing Cytoreduction and Intraperitoneal Chemoperfusion for Colorectal Carcinomatosis[NCT02399410] | Phase 2 | 60 participants (Actual) | Interventional | 2015-12-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thiotepa and Peritoneal Carcinomatosis
| Article | Year |
|---|---|
Malignant mesothelioma in children: report of seven cases and review of the literature.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Lung Neoplasms; Male; Mesothel | 1981 |
Therapeutic approaches in malignant mesothelioma.
Topics: Alkylating Agents; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, | 1977 |
11 other studies available for thiotepa and Peritoneal Carcinomatosis
| Article | Year |
|---|---|
[DATA ON THE USE OF THIO-TEPA IN COMBINED TREATMENT OF PATIENTS WITH MALIGNANT OVARIAN TUMORS].
Topics: Adnexa Uteri; Choriocarcinoma; Cystadenoma; Cystadenoma, Mucinous; Dermoid Cyst; Female; Humans; Hys | 1963 |
[Intratumor chemotherapy of patients with cancer of the ovaries].
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Cyst | 1983 |
Clinical delivery system for intraperitoneal hyperthermic chemotherapy.
Topics: Adult; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cystadenoma; Drug Therapy, C | 1980 |
[Mitotic activity changes in serous ovarian cystadenocarcinomas under treated with chemotherapy].
Topics: Adult; Aged; Cystadenoma; Dose-Response Relationship, Drug; Female; Humans; Lymphatic Metastasis; Mi | 1980 |
[Experimental chemotherapy of peritoneal carcinomatosis of colonic origin in rats].
Topics: Animals; Antineoplastic Agents; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Disease Models, Anim | 1992 |
Phase I clinical and pharmacokinetic study of thiotepa administered intraperitoneally in patients with advanced malignancies.
Topics: Adult; Aged; Aged, 80 and over; Blood Proteins; Drug Evaluation; Female; Humans; Infusions, Parenter | 1989 |
[Local treatment of carcinomatous effusions with triethylenethiophosphoramide (thio-tepa)].
Topics: Aged; Exudates and Transudates; Female; Humans; Male; Middle Aged; Palliative Care; Peritoneal Neopl | 1966 |
Pseudomyxoma peritonei.
Topics: Cystadenoma; Female; Humans; Ovarian Neoplasms; Peritoneal Neoplasms; Thiotepa | 1969 |
Pseudomyxoma peritonaei: a report of ten cases.
Topics: Adenocarcinoma; Adult; Aged; Appendectomy; Appendiceal Neoplasms; Castration; Cystadenoma; Female; F | 1973 |
Chemotherapy of malignant mesothelioma.
Topics: Adult; Aged; Antineoplastic Agents; Female; Fluorouracil; Glucosamine; Humans; Male; Mesothelioma; M | 1974 |
[The anti-tumor effect of several mono- and di-chlor-sym.triazine derivatives].
Topics: Animals; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Female; Leukopenia; Lung Neoplasms; Lympho | 1970 |