thiotepa has been researched along with Pancytopenia in 6 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Pancytopenia: Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study was designed to determine the toxicity, feasibility, and effectiveness of high-dose cyclophosphamide (6 g/m2), thiotepa (500 mg/m2) and carboplatin (800 mg/m2 (CTCb) with hematopoietic rescue as consolidation after standard-dose adjuvant chemotherapy treatment of primary high-risk breast cancer." | 5.08 | Results of a pilot study of 40 patients using high-dose therapy with hematopoietic rescue after standard-dose adjuvant therapy for high-risk breast cancer. ( Escudero, A; Fernández-Rañada, JM; López-Lorenzo, JL; López-Pascual, J; Pérez-Carrión, R; Tomás, JF, 1997) |
| "Rapidly fatal acute myelogenous leukemia (AML) occurred in a woman with advanced (Stage III) ovarian carcinoma who was treated with thiotepa for 30 months." | 4.75 | Ovarian carcinoma terminating in acute nonlymphocytic leukemia following alkylating agent therapy. ( Kapadia, SB; Krause, JR, 1978) |
| "This retrospective analysis was done to determine the response rate and survival of women with metastatic breast cancer with bone marrow involvement treated with high-dose cyclophosphamide and thiotepa and peripheral progenitor cell rescue." | 3.69 | High-dose chemotherapy with autologous stem cell rescue in women with metastatic breast cancer with involved bone marrow: a role for peripheral blood progenitor transplant. ( Mick, R; Myers, SE; Williams, SF, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| PLAUCHU, M | 1 |
| DALMAIS, J | 1 |
| CHATAING, B | 1 |
| PHILIBERT, S | 1 |
| Agnelli, G | 1 |
| de Cunto, M | 1 |
| Gresele, P | 1 |
| del Favero, A | 1 |
| Myers, SE | 1 |
| Mick, R | 1 |
| Williams, SF | 1 |
| Tomás, JF | 1 |
| Pérez-Carrión, R | 1 |
| Escudero, A | 1 |
| López-Lorenzo, JL | 1 |
| López-Pascual, J | 1 |
| Fernández-Rañada, JM | 1 |
| Kapadia, SB | 1 |
| Krause, JR | 1 |
1 review available for thiotepa and Pancytopenia
| Article | Year |
|---|---|
Ovarian carcinoma terminating in acute nonlymphocytic leukemia following alkylating agent therapy.
Topics: Adult; Aged; Female; Humans; Leukemia, Myeloid, Acute; Middle Aged; Neoplasms, Multiple Primary; Ova | 1978 |
1 trial available for thiotepa and Pancytopenia
| Article | Year |
|---|---|
Results of a pilot study of 40 patients using high-dose therapy with hematopoietic rescue after standard-dose adjuvant therapy for high-risk breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Chemotherapy, | 1997 |
4 other studies available for thiotepa and Pancytopenia
| Article | Year |
|---|---|
[3 cases of bone marrow aplasia, 1 of which is curable, due to triethylene thio-phosphoramide of RP 10, 090].
Topics: Anemia; Anemia, Aplastic; Bone Marrow; Humans; Pancytopenia; Phosphoramides; Thiotepa | 1962 |
Early onset life-threatening myelosuppression after low dose of intravesical thiotepa.
Topics: Aged; Carcinoma, Papillary; Humans; Male; Pancytopenia; Thiotepa; Urinary Bladder Neoplasms | 1982 |
High-dose chemotherapy with autologous stem cell rescue in women with metastatic breast cancer with involved bone marrow: a role for peripheral blood progenitor transplant.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Component Transfusion; Blood Transfusio | 1994 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 28-1977.
Topics: Aged; Carcinoma, Transitional Cell; Diagnosis, Differential; Female; Humans; Leukemia, Myeloid, Acut | 1977 |