thiotepa has been researched along with Nausea in 7 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Seventy patients with breast cancer received high-dose cyclophosphamide, thiotepa and carboplatin (CTCb) for 3 consecutive days." | 5.08 | A randomized trial of once vs twice daily administration of intravenous granisetron with dexamethosone in patients receiving high-dose cyclophosphamide, thiotepa and carboplatin. ( Birch, R; Buckner, CD; Carson, K; Weaver, CH, 1998) |
| "As aprepitant has been shown to be a moderate inhibitor of the cytochrome P450 (CYP) 3A4 isoenzyme, its effect on the pharmacokinetics and metabolism of cyclophosphamide and thiotepa was evaluated." | 2.71 | Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism. ( Beijnen, JH; de Jonge, ME; Holtkamp, MJ; Huitema, AD; Rodenhuis, S; van Dam, SM, 2005) |
| "There were three atrial arrhythmias, two ventricular arrhythmias, and four atrioventricular (AV)-block episodes." | 1.31 | Cardiac conduction abnormalities in patients with breast cancer undergoing high-dose chemotherapy and stem cell transplantation. ( Adachi, I; Ando, M; Kawahigashi, N; Kobayashi, Y; Mineishi, S; Narabayashi, M; Sawada, J; Takaue, Y; Takeyama, K; Tanosaki, R; Tobinai, K; Togitani, K; Watanabe, T; Yokozawa, T, 2000) |
| " The BAD pump was safe and effective in minimizing nausea and vomiting associated with HDC, and thus, eliminated the need for hospitalization for management of chemotherapy-induced nausea and vomiting." | 1.30 | Safety and efficacy of a continuous infusion, patient controlled anti-emetic pump to facilitate outpatient administration of high-dose chemotherapy. ( Belt, R; Coon, J; Cord, M; Dix, S; Geller, R; Howard, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| TOURNEUR, R | 1 |
| GRIVAUX, M | 1 |
| LAMOTTE-BARRILLON, S | 1 |
| de Jonge, ME | 1 |
| Huitema, AD | 1 |
| Holtkamp, MJ | 1 |
| van Dam, SM | 1 |
| Beijnen, JH | 1 |
| Rodenhuis, S | 1 |
| Legha, SS | 1 |
| Ajani, JA | 1 |
| Blumenschein, GR | 1 |
| Hortobagyi, GN | 1 |
| Buzdar, AU | 1 |
| Birch, R | 1 |
| Weaver, CH | 1 |
| Carson, K | 1 |
| Buckner, CD | 1 |
| Dix, S | 1 |
| Cord, M | 1 |
| Howard, S | 1 |
| Coon, J | 1 |
| Belt, R | 1 |
| Geller, R | 1 |
| Ando, M | 1 |
| Yokozawa, T | 1 |
| Sawada, J | 1 |
| Takaue, Y | 1 |
| Togitani, K | 1 |
| Kawahigashi, N | 1 |
| Narabayashi, M | 1 |
| Takeyama, K | 1 |
| Tanosaki, R | 1 |
| Mineishi, S | 1 |
| Kobayashi, Y | 1 |
| Watanabe, T | 1 |
| Adachi, I | 1 |
| Tobinai, K | 1 |
| Smirnova, IN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Single-Blind Study of Nometex as an Adjunct to Standard Anti-emetics in Ovarian and Advanced Endometrial and Cervical Cancer Patients Who Receive Moderately to Highly Emetogenic Chemotherapy[NCT01980160] | 0 participants (Actual) | Interventional | 2013-11-30 | Withdrawn (stopped due to Did not receive IRB approval from our institution therefore the study was closed.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for thiotepa and Nausea
| Article | Year |
|---|---|
Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism.
Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Aprepitant; Breast Neoplasms; Carboplat | 2005 |
A randomized trial of once vs twice daily administration of intravenous granisetron with dexamethosone in patients receiving high-dose cyclophosphamide, thiotepa and carboplatin.
Topics: Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; C | 1998 |
5 other studies available for thiotepa and Nausea
| Article | Year |
|---|---|
[DIGESTIVE INTOLERANCE TO DIGITALIN, CYTOSTATIC DRUGS AND VARIOUS THERAPEUTIC DRUGS. THEIR TREATMENT WITH METHOCLOPRAMIDE].
Topics: Antiemetics; Antitubercular Agents; Cobalt Isotopes; Cyclophosphamide; Cytostatic Agents; Digitalis | 1964 |
Combination chemotherapy of metastatic breast carcinoma with cyclophosphamide, adriamycin, and peptichemio.
Topics: Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Neoplasms; | 1984 |
Safety and efficacy of a continuous infusion, patient controlled anti-emetic pump to facilitate outpatient administration of high-dose chemotherapy.
Topics: Adult; Ambulatory Care; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasm | 1999 |
Cardiac conduction abnormalities in patients with breast cancer undergoing high-dose chemotherapy and stem cell transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Breast Neoplasms; Combi | 2000 |
[Results of treatment of tonsillar tumors by olivomycin].
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Chlorpromazine; Cyclophosp | 1969 |