thiotepa has been researched along with Meningitis in 5 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Meningitis: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This prospective randomized cooperative group study was conducted in patients with neoplastic meningitis treated with intrathecal methotrexate or thiotepa to assess response rates and survival, prognostic factors, and the toxicity of these regimens." | 9.07 | Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group. ( Ettinger, DS; Finkelstein, DM; Grossman, SA; Moynihan, T; Ruckdeschel, JC; Trump, DL, 1993) |
| "This prospective randomized cooperative group study was conducted in patients with neoplastic meningitis treated with intrathecal methotrexate or thiotepa to assess response rates and survival, prognostic factors, and the toxicity of these regimens." | 5.07 | Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group. ( Ettinger, DS; Finkelstein, DM; Grossman, SA; Moynihan, T; Ruckdeschel, JC; Trump, DL, 1993) |
| "This study analyzes the clinical and bacteriologic features of CSF infections that occurred in patients with neoplastic meningitis treated with thiotepa and methotrexate administered through a subcutaneous reservoir and ventricular catheter (SRVC)." | 3.66 | CSF infections complicating the management of neoplastic meningitis. Clinical features and results of therapy. ( Grossman, SA; Murray, K; Thompson, G; Trump, DL, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Armstrong, TS | 1 |
| Gilbert, MR | 1 |
| Trump, DL | 2 |
| Grossman, SA | 2 |
| Thompson, G | 1 |
| Murray, K | 1 |
| Finkelstein, DM | 1 |
| Ruckdeschel, JC | 1 |
| Moynihan, T | 1 |
| Ettinger, DS | 1 |
| Chamberlain, MC | 2 |
| Kormanik, PA | 2 |
| Barba, D | 1 |
2 trials available for thiotepa and Meningitis
| Article | Year |
|---|---|
Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cerebrospinal Fluid; Female; Humans; Injection | 1993 |
Non-AIDS-related lymphomatous meningitis: combined modality therapy.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Comb | 1997 |
3 other studies available for thiotepa and Meningitis
| Article | Year |
|---|---|
The treatment of neoplastic meningitis.
Topics: Antineoplastic Agents; Cytarabine; Humans; Injections, Intraventricular; Injections, Spinal; Meningi | 2004 |
CSF infections complicating the management of neoplastic meningitis. Clinical features and results of therapy.
Topics: Adult; Breast Neoplasms; Catheters, Indwelling; Cerebral Ventricles; Cerebrospinal Fluid; Female; Hu | 1982 |
Complications associated with intraventricular chemotherapy in patients with leptomeningeal metastases.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineo | 1997 |