thiotepa has been researched along with Meningeal Neoplasms in 26 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Meningeal Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This prospective randomized cooperative group study was conducted in patients with neoplastic meningitis treated with intrathecal methotrexate or thiotepa to assess response rates and survival, prognostic factors, and the toxicity of these regimens." | 9.07 | Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group. ( Ettinger, DS; Finkelstein, DM; Grossman, SA; Moynihan, T; Ruckdeschel, JC; Trump, DL, 1993) |
| "This prospective randomized cooperative group study was conducted in patients with neoplastic meningitis treated with intrathecal methotrexate or thiotepa to assess response rates and survival, prognostic factors, and the toxicity of these regimens." | 5.07 | Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group. ( Ettinger, DS; Finkelstein, DM; Grossman, SA; Moynihan, T; Ruckdeschel, JC; Trump, DL, 1993) |
| "A total of 56 patients were identified with breast cancer leptomeningeal disease at our institution treated with IT trastuzumab (n = 18; 32%), single-agent IT chemotherapy (methotrexate n = 14 or thiotepa n = 1; 27%), or WBRT alone (n = 23; 41%)." | 3.91 | Clinical outcomes of breast leptomeningeal disease treated with intrathecal trastuzumab, intrathecal chemotherapy, or whole brain radiation therapy. ( Ahmed, KA; Czerniecki, BJ; Diaz, R; Etame, AB; Evernden, B; Figura, NB; Forsyth, PA; Han, HS; Liu, J; Mohammadi, H; Mokhtari, S; Rizk, VT; Robinson, TJ; Sahebjam, S; Soliman, H; Tran, ND; Washington, I; Yu, HM, 2019) |
| "This study analyzes the clinical and bacteriologic features of CSF infections that occurred in patients with neoplastic meningitis treated with thiotepa and methotrexate administered through a subcutaneous reservoir and ventricular catheter (SRVC)." | 3.66 | CSF infections complicating the management of neoplastic meningitis. Clinical features and results of therapy. ( Grossman, SA; Murray, K; Thompson, G; Trump, DL, 1982) |
| "Leptomeningeal carcinomatosis is defined as malignant infiltration of the pia matter and arachnoid membrane." | 2.43 | Management of leptomeningeal malignancy. ( Pavlidis, N; Pentheroudakis, G, 2005) |
| "9 X 10(-4)M, and remained as a level of 10(-6)M for 72 hours with a half-life of 10." | 1.27 | [Pharmacokinetics of intrathecal chemotherapy and clinical problems]. ( Fujimoto, T, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (30.77) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Claudel, A | 1 |
| Talbot, A | 1 |
| Harel, S | 1 |
| Royer, B | 1 |
| Naelle, L | 1 |
| Zagdanski, AM | 1 |
| Madelaine, I | 1 |
| Lemaire, P | 1 |
| Arnulf, B | 1 |
| Figura, NB | 1 |
| Rizk, VT | 1 |
| Mohammadi, H | 1 |
| Evernden, B | 1 |
| Mokhtari, S | 1 |
| Yu, HM | 1 |
| Robinson, TJ | 1 |
| Etame, AB | 1 |
| Tran, ND | 1 |
| Liu, J | 1 |
| Washington, I | 1 |
| Diaz, R | 1 |
| Czerniecki, BJ | 1 |
| Soliman, H | 1 |
| Han, HS | 1 |
| Sahebjam, S | 1 |
| Forsyth, PA | 1 |
| Ahmed, KA | 1 |
| Le Rhun, E | 1 |
| Taillibert, S | 1 |
| Devos, P | 1 |
| Zairi, F | 1 |
| Turpin, A | 1 |
| Rodrigues, I | 1 |
| Cazin, JL | 1 |
| Pierret, MF | 1 |
| André, C | 1 |
| Dubois, F | 1 |
| Bonneterre, J | 1 |
| Chamberlain, MC | 4 |
| Cho, KM | 1 |
| Kim, YJ | 1 |
| Kim, SH | 1 |
| Kim, JW | 1 |
| Lee, JO | 1 |
| Han, JH | 1 |
| Lee, KW | 1 |
| Kim, JH | 1 |
| Kim, CY | 1 |
| Bang, SM | 1 |
| Kim, IA | 1 |
| Kim, JS | 1 |
| Lee, JS | 1 |
| Mack, F | 1 |
| Baumert, BG | 1 |
| Schäfer, N | 1 |
| Hattingen, E | 1 |
| Scheffler, B | 1 |
| Herrlinger, U | 1 |
| Glas, M | 1 |
| Ferrario, C | 1 |
| Davidson, A | 1 |
| Bouganim, N | 1 |
| Aloyz, R | 1 |
| Panasci, LC | 1 |
| Pentheroudakis, G | 1 |
| Pavlidis, N | 1 |
| Ferreri, AJ | 1 |
| Dell'Oro, S | 1 |
| Foppoli, M | 1 |
| Bernardi, M | 1 |
| Brandes, AA | 1 |
| Tosoni, A | 1 |
| Montanari, M | 1 |
| Balzarotti, M | 1 |
| Spina, M | 1 |
| Ilariucci, F | 1 |
| Zaja, F | 1 |
| Stelitano, C | 1 |
| Bobbio, F | 1 |
| Corazzelli, G | 1 |
| Baldini, L | 1 |
| Ponzoni, M | 1 |
| Picozzi, P | 1 |
| Caligaris Cappio, F | 1 |
| Reni, M | 1 |
| Popovic, MB | 1 |
| Diezi, M | 1 |
| Kuchler, H | 1 |
| Abouzeid, H | 1 |
| Maeder, P | 1 |
| Balmer, A | 1 |
| Munier, FL | 1 |
| Fujimoto, T | 1 |
| Lokich, J | 1 |
| Galbo, C | 1 |
| Edwards, MS | 1 |
| Levin, VA | 1 |
| Seager, ML | 1 |
| Wilson, CB | 1 |
| Trump, DL | 4 |
| Grossman, SA | 4 |
| Thompson, G | 3 |
| Murray, K | 2 |
| Wharam, M | 1 |
| Chen, DC | 1 |
| Camargo, EE | 1 |
| Liebmann, J | 1 |
| Gurtler, J | 1 |
| Finkelstein, DM | 1 |
| Ruckdeschel, JC | 1 |
| Moynihan, T | 1 |
| Ettinger, DS | 1 |
| Kormanik, PA | 2 |
| Barba, D | 1 |
| Fisher, PG | 1 |
| Kadan-Lottick, NS | 1 |
| Korones, DN | 1 |
| Heath, JA | 1 |
| Broxson, EH | 1 |
| Dole, MG | 1 |
| Filippa, DA | 1 |
| George, D | 1 |
| Lyden, D | 1 |
| Dunkel, IJ | 1 |
| Blaney, SM | 1 |
| Balis, FM | 1 |
| Poplack, DG | 1 |
| Morrison, VA | 1 |
| Weinshel, EL | 1 |
| Luikart, SD | 1 |
| Giannone, L | 1 |
| Greco, FA | 1 |
| Hainsworth, JD | 1 |
| Stewart, DJ | 1 |
| Maroun, JA | 1 |
| Hugenholtz, H | 1 |
| Benoit, B | 1 |
| Girard, A | 1 |
| Richard, M | 1 |
| Russell, N | 1 |
| Huebsch, L | 1 |
| Drouin, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Involved-field Radiotherapy Combined With Concurrent Intrathecal-MTX Versus Intrathecal-Ara-C for Leptomeningeal Metastases From Solid Tumor: A Randomized Phase II Clinical Trial[NCT03082144] | Phase 2 | 53 participants (Actual) | Interventional | 2017-02-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thiotepa and Meningeal Neoplasms
| Article | Year |
|---|---|
Therapy of leptomeningeal metastasis in solid tumors.
Topics: Antineoplastic Agents; Cytarabine; Humans; Injections, Spinal; Meningeal Neoplasms; Methotrexate; Ne | 2016 |
Management of leptomeningeal malignancy.
Topics: Adenocarcinoma; Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Arac | 2005 |
4 trials available for thiotepa and Meningeal Neoplasms
| Article | Year |
|---|---|
MATILDE regimen followed by radiotherapy is an active strategy against primary CNS lymphomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neop | 2006 |
Treatment of neoplastic meningitis with intraventricular thiotepa and methotrexate.
Topics: Adult; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; | 1982 |
Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cerebrospinal Fluid; Female; Humans; Injection | 1993 |
Combination intraventricular chemotherapy for meningeal neoplasia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Cytarabi | 1986 |
20 other studies available for thiotepa and Meningeal Neoplasms
| Article | Year |
|---|---|
Thiotepa intrathecal injections for myelomatous central nervous system involvement.
Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Central Ner | 2021 |
Clinical outcomes of breast leptomeningeal disease treated with intrathecal trastuzumab, intrathecal chemotherapy, or whole brain radiation therapy.
Topics: Adult; Aged; Breast Neoplasms; Cranial Irradiation; Drug Therapy; Female; Hospitalization; Humans; I | 2019 |
Salvage intracerebrospinal fluid thiotepa in breast cancer-related leptomeningeal metastases: a retrospective case series.
Topics: Adult; Antineoplastic Agents, Alkylating; Breast Neoplasms; Disease-Free Survival; Female; Humans; M | 2013 |
Salvage Treatment with Intracerebrospinal Fluid Thiotepa in Patients with Leptomeningeal Metastasis After Failure of Methotrexate-based Treatment.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Female; Follow-Up S | 2015 |
Intrathecal trastuzumab and thiotepa for leptomeningeal spread of breast cancer.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera | 2009 |
Trilateral retinoblastoma with suprasellar tumor and associated pineal cyst.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nervous System Cysts; Child; Cy | 2007 |
[Pharmacokinetics of intrathecal chemotherapy and clinical problems].
Topics: Acute Disease; Blood-Brain Barrier; Cytarabine; Humans; Infusions, Parenteral; Injections, Spinal; K | 1984 |
Leptomeningeal lymphoma: perspectives on management.
Topics: Antineoplastic Agents; Arachnoid; Cytarabine; Humans; Injections, Spinal; Lymphoma; Meningeal Neopla | 1981 |
Intrathecal chemotherapy for leptomeningeal dissemination of medulloblastoma.
Topics: Adolescent; Antineoplastic Agents; Cerebellar Neoplasms; Child; Cytarabine; Drug Therapy, Combinatio | 1981 |
CSF infections complicating the management of neoplastic meningitis. Clinical features and results of therapy.
Topics: Adult; Breast Neoplasms; Catheters, Indwelling; Cerebral Ventricles; Cerebrospinal Fluid; Female; Hu | 1982 |
Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis. An evaluation using 111indium-DTPA ventriculography.
Topics: Cerebral Ventriculography; Cerebrospinal Fluid; Humans; Indium; Injections, Spinal; Meningeal Neopla | 1982 |
Combination intraventricular therapy with thiotepa and cytarabine in meningeal carcinomatosis due to breast cancer: in vitro evidence for supra-additive cytotoxicity.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; | 1995 |
Prognostic significance of 111indium-DTPA CSF flow studies in leptomeningeal metastases.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Cerebral Ve | 1996 |
Pediatric leptomeningeal metastases: outcome following combined therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cerebrospinal Fluid; Chemotherapy, Cance | 1997 |
Complications associated with intraventricular chemotherapy in patients with leptomeningeal metastases.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineo | 1997 |
Intrathecal thiotepa: reappraisal of an established therapy.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Cerebrospinal Fluid; Child; Child, Preschool; Cohort | 2002 |
Epstein-Barr virus-associated lymphoma in a child undergoing an autologous stem cell rescue.
Topics: Acyclovir; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Ph | 2002 |
Pharmacologic approaches to the treatment of meningeal malignancy.
Topics: Adolescent; Adult; Antineoplastic Agents; Aziridines; Benzoquinones; Blood-Brain Barrier; Child; Chi | 1991 |
Corynebacterium JK: a new pathogen in ventriculostomy infections.
Topics: Corynebacterium Infections; Cross Infection; Dexamethasone; Drug Delivery Systems; Eye Neoplasms; Hu | 1991 |
Combined intraommaya methotrexate, cytosine arabinoside, hydrocortisone and thio-TEPA for meningeal involvement by malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Hydrocortis | 1987 |