thiotepa and Melanoma studies

Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

Excerpt	Relevance	Reference
"Thiotepa was administered intravenously (IV) over two hours daily for three consecutive days followed in three to four days by marrow transplantation."	5.28	High-dose thiotepa with autologous bone marrow transplantation for metastatic malignant melanoma: results of phase I and II studies of the North American Bone Marrow Transplantation Group. ( Bolwell, B; Fay, JW; Frei-Lahr, D; Giannone, L; Herzig, GP; Herzig, RH; LeMaistre, CF; Lowder, J; Wolff, SN, 1989)
"Different pharmacologic drugs (isadrin, obsidan, phentolamine) changing adrenergic processes are shown to have different effect on the growth and development of lung metastases."	3.67	[Changes in the metastasis of experimental tumors and in the antimetastatic effect of cytostatics in their pharmacological action on adrenergic processes]. ( Balitskiĭ, KP; Riabukha, VN; Smelkova, MI; Veksler, IG, 1984)
" It is the authors' conclusion that the portable isolated limb perfusion system achieved all of the required parameters to provide safe and effective treatment for this type of melanoma."	1.29	Safe, compact and portable system for regional chemotherapeutic hyperthermic perfusion procedures. ( Faddis, D; Fried, SJ; Miller, R; Weaver, FA, 1993)
"Thiotepa was administered intravenously (IV) over two hours daily for three consecutive days followed in three to four days by marrow transplantation."	1.28	High-dose thiotepa with autologous bone marrow transplantation for metastatic malignant melanoma: results of phase I and II studies of the North American Bone Marrow Transplantation Group. ( Bolwell, B; Fay, JW; Frei-Lahr, D; Giannone, L; Herzig, GP; Herzig, RH; LeMaistre, CF; Lowder, J; Wolff, SN, 1989)

Timeframe	Studies, this research(%)	All Research%
pre-1990	67 (93.06)	18.7374
1990's	5 (6.94)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
SMART, MC	1
GUMPORT, SL	1
WRIGHT, JC	1
GOLOMB, FM	2
CONWAY, H	1
GRIFFITH, BH	1
ABBATUCCI, JS	1
KENNEDY, BJ	1
ZELICKSON, AS	1
BRINDLEY, CO	2
SMITH, JR	2
SALVIN, LG	1
POTEE, KG	1
LIPOWSKA, B	1
SHNIDER, BI	1
REGELSON, W	1
COLSKY, J	1
CHRISTLIEB, II	1
ALRICH, EM	1
MAUER, AM	1
KRILL, CE	1
VIGI, F	1
CREECH, O	2
KREMENTZ, ET	6
ARIEL, IM	1
RESNICK, MI	1
GALEY, D	1
POMMATAU, E	1
DARGENT, M	1
REVILLARD, JP	1
MOORE, JG	1
VANCAMPENHOUT, JL	1
BRANDKAMP, WW	1
SLOBODA, AE	1
VOGEL, AW	1
HILLER, SA	1
LIDAKS, MJ	1
ZIDERMANE, AA	1
GERMANE, SK	1
GRIGALINOVICH, GA	1
DAUVARTS, AZ	1
KRAVCHENKO, IM	1
PRESS, BO	1
COBB, JP	1
WALKER, DG	1
VERMEL, EM	1
DOWD, JE	1
DIPAOLO, JA	1
WATNE, AL	1
LAWTON, RL	1
LAGARDE, C	1
HIRTZ, G	1
HUGUES, A	1
CHAUVERGNE, J	1
HOERNI, B	1
BIRINGER, A	1
HOLAN, J	1
MEDLA, F	1
ROSENGERG, LM	1
POLANCO, GB	1
BLANK, S	1
MEHTA, RD	1
RIDDELL, AG	1
Veksler, IG	1
Riabukha, VN	1
Smelkova, MI	1
Balitskiĭ, KP	1
Hofer, D	2
Dubitsky, AM	1
Reïlly, P	2
Santoro, MG	2
Jaffe, BM	2
Mena, H	1
Garcia, JH	1
Velandia, F	1
Dubitsky, A	1
Marti, J	1
Carter, RD	2
Sutherland, CM	2
Muchmore, JH	2
Ryan, RF	2
Ariyan, S	1
Poo, WJ	1
Bolognia, J	1
Fried, SJ	1
Miller, R	1
Weaver, FA	1
Faddis, D	1
Milton, GW	1
McCarthy, WH	1
Levin, AO	3
Stepanova, NS	2
Chikinda, IuN	1
Jacquillat, C	2
Banzet, P	2
Civatte, J	1
Puissant, A	1
Cottenot, F	1
Israel, L	1
Belaich, S	1
Chastang, C	1
Maral, J	2
Cox, KR	2
Berry, RJ	1
Laing, AH	1
Wells, J	1
Glover, DJ	1
Morrison, VA	1
Weinshel, EL	1
Luikart, SD	1
Wolff, SN	1
Herzig, RH	1
Fay, JW	1
LeMaistre, CF	1
Frei-Lahr, D	1
Lowder, J	1
Bolwell, B	1
Giannone, L	2
Herzig, GP	1
Greco, FA	1
Hainsworth, JD	1
Sellami, M	1
Weil, M	1
Auclerc, G	1
Dhermy, P	1
Aron-Rosa, D	1
Gary-Bobo, J	1
Richard, JM	1
Sancho, H	1
Potopal'skiĭ, AI	1
Shishka, GV	1
Iordan, AM	1
Moskalik, KG	1
Kozlov, AP	1
Akimov, AA	1
Wallace, JD	1
Lisichkina-Nifantova, TP	2
Hill, GJ	1
Larsen, RR	1
Kokame, GM	1
Fish, J	1
Smith, EB	1
Canby, JP	1
Mahaley, MS	1
Woodhall, B	1
Horton, J	1
Olson, K	1
Mannes, P	1
Derriks, R	1
Moens, R	1
Heynen, E	1
Harvin, JS	1
Grants, EA	1
Utkin, VV	1
Utkin, AV	1
Boeckl, O	1
Hell, E	1
Zimmermann, G	1
Kolessov, VI	1
Körlof, B	1
Kolesov, VI	1
Martyniuk, VV	1
Sidorenko, LN	1
Couture, J	1
Deschênes, L	1
Kotelianskiĭ, EO	1
Stengrevits, AA	1
Semenov, AD	1
Eroshevskiĭ, TI	1
Dufourmentel, C	1
Pailheret, JP	1
Palmer, JD	1

Article	Year
[Use of optical quantum generators (lasers) in oncology]. Voprosy onkologii, 1972, Volume: 18, Issue:8 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bronchial Neoplasms; Carcinoma, Basal Cell; Carcinom	1972
Free radicals and neoplasia--some experimental findings and some possible implications. CRC critical reviews in radiological sciences, 1972, Volume: 3, Issue:1 Topics: Adenofibroma; Animals; Breast Neoplasms; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Carcinoma	1972
[Regional perfusion therapy of malignant tumors of the extremities]. Deutsche medizinische Wochenschrift (1946), 1970, Mar-27, Volume: 95, Issue:13 Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regi	1970
[Some current problems in the therapy of intraocular tumors]. Oftalmologicheskii zhurnal, 1971, Volume: 26, Issue:3 Topics: Cryosurgery; Eye Neoplasms; Female; Humans; Laser Therapy; Male; Melanoma; Methods; Neoplasm Metasta	1971

Article	Year
The use of thio-tepa (triethylene thiophosphoramide) in melanotic sarcoma. Canadian Medical Association journal, 1957, Aug-15, Volume: 77, Issue:4 Topics: Antineoplastic Agents; Humans; Melanoma; Neoplasms; Sarcoma; Thiotepa	1957
The treatment of advanced malignant melanoma with triethylene thiophosphoramide (Thio-TEPA or TSPA). Annals of surgery, 1958, Volume: 147, Issue:2 Topics: Antineoplastic Agents; Humans; Melanoma; Thiotepa	1958
Carcinolytic effect of local triethylenethiophosphoramide (thio-TEPA) on malignant melanoma. American journal of surgery, 1958, Volume: 95, Issue:6 Topics: Antineoplastic Agents; Humans; Melanoma; Thiotepa	1958
[Anticancer chemotherapy with thio-tepa. Results obtained in 40 cases]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1963, Apr-14, Volume: 39 Topics: Breast Neoplasms; Esophageal Neoplasms; Female; Humans; Melanoma; Multiple Myeloma; Ovarian Neoplasm	1963
MELANOMA IN AN ALBINO. JAMA, 1963, Nov-30, Volume: 186 Topics: Albinism; Electrons; Mechlorethamine; Melanins; Melanoma; Microscopy; Microscopy, Electron; Neoplasm	1963
METHODOLOGY OF PRELIMINARY CHEMOTHERAPEUTIC TRIALS IN PATIENTS WITH MALIGNANT SOLID TUMORS. Cancer chemotherapy reports, 1963, Volume: 32 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Colonic Neoplasms; Cyclophosp	1963
LYMPHATIC CANNULATION OF THE HEAD AND NECK. Plastic and reconstructive surgery, 1963, Volume: 32 Topics: Catheterization; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Head; Head and Neck Neo	1963
FURTHER COMPARATIVE TRIAL OF TRIETHYLENE THIOPHOSPHORAMIDE AND MECHLORETHAMINE IN PATIENTS WITH MELANOMA AND HODGKIN'S DISEASE. Journal of chronic diseases, 1964, Volume: 17 Topics: District of Columbia; Hodgkin Disease; Mechlorethamine; Melanoma; New York; Thiotepa; Toxicology	1964
ISOLATION PERFUSION AS AN ADJUNCTIVE TREATMENT FOR MELANOMA OF THE EXTREMITIES. Virginia medical monthly, 1964, Volume: 91 Topics: Chemotherapy, Cancer, Regional Perfusion; Extracorporeal Circulation; Extremities; Humans; Melanoma;	1964
A STUDY OF THE MECHANISMS OF GRANULOCYTOPENIA. Annals of the New York Academy of Sciences, 1964, Feb-28, Volume: 113 Topics: Agranulocytosis; Anemia; Anemia, Macrocytic; Carcinoma; Carcinoma, Bronchogenic; Child; Hodgkin Dise	1964
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES]. Minerva medica, 1963, Nov-03, Volume: 54 Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambuci	1963
REGIONAL PERFUSION IN MELANOMA OF LIMBS. JAMA, 1964, Jun-08, Volume: 188 Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Extremities; Humans; Mechlorethamin	1964
THE INTRALYMPHATIC ADMINISTRATION OF RADIOACTIVE ISOTOPES AND CANCER CHEMOTHERAPEUTIC DRUGS. Surgery, 1964, Volume: 55 Topics: Abdominal Neoplasms; Angiography; Breast Neoplasms; Geriatrics; Gold; Humans; Injections; Iodine Iso	1964
[TRIETHYLENE THIO-PHOSPHORAMIDE (THIO-TEPA) IN THE TREATMENT OF MALIGNANT TUMORS]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1964, Feb-14, Volume: 40 Topics: Breast Neoplasms; Female; Humans; Melanoma; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Phosp	1964
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES. American journal of obstetrics and gynecology, 1964, Apr-15, Volume: 88 Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C	1964
A LABORATORY EVALUATION OF 1,4-DIMETHYL-1,4-DIPHENYL-2-TETRAZENE (CENTRAZENE), A CARCINOSTATIC COMPOUND. Cancer research, 1964, Volume: 24 Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Carcinoma 256, Walker; Lymphoma, Non-Hodgkin; Ma	1964
ANTITUMOROUS SUBSTANCES WITH RADIOMIMETIC AND RADIOPROTECTIVE GROUPS. Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20 Topics: Acetylcholine; Antineoplastic Agents; Blood Pressure; Carcinoma 256, Walker; Cats; Erythropoiesis; L	1964
STUDIES ON HUMAN MELANOMA CELLS IN TISSUE CULTURE. II. EFFECTS OF SEVERAL CANCER CHEMOTHERAPEUTIC AGENTS ON CYTOLOGY AND GROWTH. Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20 Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chlorambucil; Dactinomycin; Fluorouracil; Melanoma; Me	1964
THE SEARCH FOR ANTITUMOUR SUBSTANCES OF PLANT ORIGIN. Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20 Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Coumarins; Gossypol; Melanoma; Mice; Neopl	1964
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION. Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20 Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neop	1964
JET INJECTION OF DRUGS INTO MALIGNANT NEOPLASMS. Cancer chemotherapy reports, 1964, Volume: 37 Topics: Breast Neoplasms; Drug Therapy; Equipment and Supplies; Humans; Injections; Injections, Jet; Melanom	1964
[PALLIATIVE TREATMENT OF CANCERS WITH THIO-TEPA. STUDY OF 115 CASES. VALUE IN BREAST CANCERS]. La Presse medicale, 1964, Sep-23, Volume: 72 Topics: Biopsy; Breast Neoplasms; Female; Humans; Melanoma; Neoplasms; Ovarian Neoplasms; Palliative Care; R	1964
OUR EXPERIENCES WITH CYTOSTATIC PERFUSIONS OF THE EXTREMITIES IN THE TREATMENT OF MALIGNANT TUMORS. Neoplasma, 1964, Volume: 11 Topics: Animals; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Dogs; Drug Ther	1964
MULTIPLE TRACHEOBRONCHIAL MELANOMAS WITH TEN-YEAR SURVIVAL. JAMA, 1965, May-24, Volume: 192 Topics: Bronchial Neoplasms; Cheek; Cobalt Isotopes; Drug Therapy; Head and Neck Neoplasms; Lymphedema; Lymp	1965
CANCER CELLS IN BLOOD OF PATIENTS WITH MALIGNANT MELANOMA TREATED BY REGIONAL PERFUSION. Cancer, 1965, Volume: 18 Topics: Blood; Cell Nucleus; Chemotherapy, Cancer, Regional Perfusion; Cytoplasm; Drug Therapy; Humans; Mela	1965
[Changes in the metastasis of experimental tumors and in the antimetastatic effect of cytostatics in their pharmacological action on adrenergic processes]. Eksperimental'naia onkologiia, 1984, Volume: 6, Issue:6 Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Evaluation, Preclinical; Drug Therapy, Combin	1984
The interactions between indomethacin and cytotoxic drugs in mice bearing B-16 melanomas. Prostaglandins, 1980, Volume: 20, Issue:6 Topics: 16,16-Dimethylprostaglandin E2; Animals; Cell Count; Cell Division; Doxorubicin; Female; Fluorouraci	1980
Central and peripheral myelinopathy associated with systemic neoplasia and chemotherapy. Cancer, 1981, Oct-15, Volume: 48, Issue:8 Topics: Adult; Aged; Axons; Brain; Cytarabine; Cytoskeleton; Female; Humans; Injections, Spinal; Leukemia; M	1981
Prostaglandin E augments the effect of chemotherapy on B-16 melanoma in vivo. The Journal of surgical research, 1982, Volume: 32, Issue:6 Topics: Animals; Antineoplastic Agents; Dopamine; Doxorubicin; Drug Therapy, Combination; Female; Fluorourac	1982
Regional chemotherapy for melanoma. A 35-year experience. Annals of surgery, 1994, Volume: 220, Issue:4 Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Clinical Trials as Topic; Combined Modality T	1994
Regional isolated perfusion of extremities for melanoma: a 20-year experience with drugs other than L-phenylalanine mustard. Plastic and reconstructive surgery, 1997, Volume: 99, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carboplatin; Chemotherapy, Cancer, Regional P	1997
Safe, compact and portable system for regional chemotherapeutic hyperthermic perfusion procedures. The journal of extra-corporeal technology, 1993, Volume: 25, Issue:1 Topics: Adult; Aged; Arm; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Dactinomycin;	1993
Chemotherapy for malignant melanoma: a brief review and personal experience. The Australian and New Zealand journal of surgery, 1978, Volume: 48, Issue:1 Topics: Bacterial Vaccines; BCG Vaccine; Corynebacterium; Humans; Imidazoles; Lymphatic Metastasis; Melanoma	1978
[Comparative evaluation of treatment results of melanoblastoma of the limbs with or without perfusion chemotherapy]. Vestnik khirurgii imeni I. I. Grekova, 1979, Volume: 122, Issue:2 Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Humans; Male; Melanoma;	1979
Adjuvant chemotherapy or chemoimmunotherapy in the management of primary malignant melanoma of level III, IV, or V. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1978, Volume: 68 Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Bacterial Vaccines; BCG Vaccine; Dacarbazine; Drug	1978
Survival after regional perfusion for limb melanoma. The Australian and New Zealand journal of surgery, 1975, Volume: 45, Issue:1 Topics: Amputation, Surgical; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Humans; Lymphat	1975
Fresh explant culture of human tumours in vitro and the assessment of sensitivity to cytotoxic chemotherapy. British journal of cancer, 1975, Volume: 31, Issue:2 Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Culture Techniques; Drug Evaluation, Preclini	1975
New approaches to the chemotherapy of melanoma. Oncology (Williston Park, N.Y.), 1991, Volume: 5, Issue:5 Topics: Alkaloids; Amifostine; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Proto	1991
Corynebacterium JK: a new pathogen in ventriculostomy infections. Journal of neuro-oncology, 1991, Volume: 11, Issue:1 Topics: Corynebacterium Infections; Cross Infection; Dexamethasone; Drug Delivery Systems; Eye Neoplasms; Hu	1991
High-dose thiotepa with autologous bone marrow transplantation for metastatic malignant melanoma: results of phase I and II studies of the North American Bone Marrow Transplantation Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:2 Topics: Adult; Aged; Bone Marrow Transplantation; Brain Neoplasms; Combined Modality Therapy; Dose-Response	1989
Lucy Wortham James lecture. Regional perfusion. Current sophistication, what next? Cancer, 1986, Feb-01, Volume: 57, Issue:3 Topics: Animals; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Costs and Cost Analysis; E	1986
Chemotherapy by regional perfusion for limb melanoma. The American surgeon, 1987, Volume: 53, Issue:3 Topics: Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Humans; Male; Melanoma; Melphalan; Ni	1987
[Adjuvant chemotherapy of intraocular malignant melanoma. Apropos of 20 cases]. Journal francais d'ophtalmologie, 1985, Volume: 8, Issue:5 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy;	1985
[Mitomycin alone and in therapeutic association in the palliative treatment of solid tumors]. Journal de radiologie, d'electrologie, et de medecine nucleaire, 1971, Volume: 52, Issue:12 Topics: Antineoplastic Agents; Breast Neoplasms; Cobalt Isotopes; Cyclophosphamide; Drug Combinations; Femal	1971
[Intra-arterial chemotherapy of head and neck tumors: statistical study of 129 cases treated at the Institut Gustave Roussy]. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1973, Volume: 18, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Bleomycin; Carcinoma; Carcinoma, Squamous Cell; Facial Neoplasms	1973
[Antitumor action of berberinol thiophosphamide in experimental tumors in mice]. Voprosy onkologii, 1974, Volume: 20, Issue:4 Topics: Adenocarcinoma; Animals; Body Weight; Carcinoma, Ehrlich Tumor; Dose-Response Relationship, Drug; Fe	1974
[Thio-tepa (triethylamine thiophosphamide) in complex treatment of patients with melanoblastoma of the uveal tract]. Oftalmologicheskii zhurnal, 1972, Volume: 27, Issue:1 Topics: Animals; Eye Neoplasms; Humans; Melanoma; Neoplasms, Experimental; Rabbits; Thiotepa; Transplantatio	1972
Chemotherapy of melanoma of the extremities by perfusion: fourteen years clinical experience. Annals of surgery, 1972, Volume: 175, Issue:6 Topics: Adult; Aged; Arm; Chemotherapy, Cancer, Regional Perfusion; Female; Humans; Leg; Male; Mechlorethami	1972
Perfusion of melanoma. 105 isolated perfusions in 92 patients. Oncology, 1972, Volume: 26, Issue:2 Topics: Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Humans; Melanoma; Melphalan; Neoplasm Recurr	1972
Cancer chemotherapy. I. Methods, agents and overall results in 400 patients. Oncology, 1972, Volume: 26, Issue:2 Topics: Adenocarcinoma; Amides; Androgens; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Estrogens;	1972
Regional chemotherapy of cancer of the head and neck. The Laryngoscope, 1966, Volume: 76, Issue:5 Topics: Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Head; Head	1966
Malignant melanoma in childhood. Surgery, 1966, Volume: 59, Issue:2 Topics: Humans; Infant; Lymph Node Excision; Male; Melanoma; Neoplasm Metastasis; Neoplasm Recurrence, Local	1966
Regional perfusion for peripheral melanoma. The Australian and New Zealand journal of surgery, 1966, Volume: 36, Issue:1 Topics: Adolescent; Adult; Chemotherapy, Cancer, Regional Perfusion; Female; Humans; Male; Melanoma; Melphal	1966
Regional chemotherapeutic perfusion and infusion of brain and face tumors. Annals of surgery, 1967, Volume: 166, Issue:2 Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carci	1967
[Are combinations more effective than monotherapy in the matter of antiocancer chemotherapy?]. Le Poumon et le coeur, 1968, Volume: 24, Issue:1 Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Drug Synergism; Female; Fluorouracil; Fl	1968
[Antineoplastic polychemotherapy in thoracic pathology]. Le Poumon et le coeur, 1968, Volume: 24, Issue:1 Topics: Adrenalectomy; Aged; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Cortisone; Cyclop	1968
Treatment of melanoma by lymphatic perfusion and regional lymph node excision: a preliminary report. The American surgeon, 1968, Volume: 34, Issue:8 Topics: Coloring Agents; Humans; Lymph Node Excision; Lymphatic Metastasis; Melanoma; Perfusion; Thiotepa	1968
[On the treatment of malignant tumors of the extremities]. Voprosy onkologii, 1966, Volume: 12, Issue:9 Topics: Amputation, Surgical; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion; Extremitie	1966
[Combined treatment of malignant tumors of the extremities. Regional perfusion chemotherapy]. Minerva medica, 1970, Sep-05, Volume: 61, Issue:71 Topics: Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Extremities; Humans; Melanoma; Melphalan; Neopl	1970
[Practical treatment of malignant melanoma]. Nordisk medicin, 1970, Oct-15, Volume: 84, Issue:42 Topics: Adult; Dactinomycin; Facial Neoplasms; Female; Humans; Melanoma; Nevus; Skin Neoplasms; Thiotepa	1970
[Extensive lymphadenectomy and perfusion chemotherapy in the treatment of pigmented skin tumors of the lower extremities]. Vestnik khirurgii imeni I. I. Grekova, 1970, Volume: 104, Issue:6 Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Female; Humans; Leg; Lymph Node Excision; Mal	1970
[Chemotherapy of solid tumors]. L'union medicale du Canada, 1970, Volume: 99, Issue:6 Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Fluorour	1970
[Experimental chemotherapy of human choroid melanoblastoma]. Vestnik oftalmologii, 1971, Volume: 2 Topics: Animals; Anterior Chamber; Antibiotics, Antineoplastic; Choroid Neoplasms; Humans; Melanoma; Melphal	1971
[The efficacy of intralymphatic use of antiblastic drugs]. Voprosy onkologii, 1969, Volume: 15, Issue:3 Topics: Animals; Antineoplastic Agents; Cats; Cyclophosphamide; Dogs; Female; Gold Colloid, Radioactive; Hod	1969
[Results of treatment of melanomas of the vascular ocular membrane by photocoagulation]. Oftalmologicheskii zhurnal, 1971, Volume: 26, Issue:8 Topics: Adult; Aged; Choroid Neoplasms; Cryosurgery; Electrocoagulation; Humans; Light Coagulation; Melanoma	1971
[Chemotherapy in the treatment of nevocarcinomas]. Acta chirurgica Belgica, 1971, Volume: 70, Issue:4 Topics: Antineoplastic Agents; Humans; Melanoma; Methotrexate; Remission, Spontaneous; Thiotepa; Vinblastine	1971
Treatment of malignant melanomas of the skin. Laval medical, 1971, Volume: 42, Issue:9 Topics: Adult; Age Factors; Aged; Chemotherapy, Cancer, Regional Perfusion; Female; Humans; Male; Melanoma;	1971

thiotepa and Melanoma

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