thiotepa has been researched along with MELAS Syndrome in 1 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
MELAS Syndrome: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BERTRAM, DS | 1 |
1 other study available for thiotepa and MELAS Syndrome
| Article | Year |
|---|---|
OBSERVATIONS ON THE CHEMOSTERILANT EFFECT OF AN ALKYLATING AGENT, THIO-TEPA, ON WILD-CAUGHT ANOPHELES GAMBIAE VAR. MELAS (THEO.) IN GAMBIA, WEST AFRICA, AND ON LABORATORY-BRED A. G. GAMBIAE GILES AND AEDES AEGYPTI (L.).
Topics: Aedes; Africa, Western; Alkylating Agents; Animals; Anopheles; Chemosterilants; Gambia; MELAS Syndro | 1963 |