thiotepa has been researched along with Lymphoma, Mantle-Cell in 2 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Lymphoma, Mantle-Cell: A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to decrease nonrelapse mortality, and enhance the graft-versus-tumor effect, a program was designed in which a reduced conditioning with thiotepa, fludarabine, and cyclophosphamide was associated with programmed reinfusions of donor lymphocytes for patients without graft-versus-host disease (GVHD), not achieving clinical and molecular remission after transplantation." | 3.71 | Reduced-intensity conditioning followed by allografting of hematopoietic cells can produce clinical and molecular remissions in patients with poor-risk hematologic malignancies. ( Benedetti, F; Bordignon, C; Bregni, M; Ciceri, F; Corradini, P; Dodero, A; Falda, M; Gianni, AM; Ladetto, M; Lucesole, M; Olivieri, A; Pileri, A; Rambaldi, A; Sajeva, MR; Tarella, C; Tresoldi, M; Voena, C; Zallio, F, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fenske, TS | 1 |
| Kahl, BS | 1 |
| Eickhoff, J | 1 |
| Mitchell, TL | 1 |
| Smith, EP | 1 |
| Atkinson, E | 1 |
| McCoy, AG | 1 |
| Eckstein, L | 1 |
| Flynn, B | 1 |
| McMannes, J | 1 |
| Howard, S | 1 |
| Longo, WL | 1 |
| Corradini, P | 1 |
| Tarella, C | 1 |
| Olivieri, A | 1 |
| Gianni, AM | 1 |
| Voena, C | 1 |
| Zallio, F | 1 |
| Ladetto, M | 1 |
| Falda, M | 1 |
| Lucesole, M | 1 |
| Dodero, A | 1 |
| Ciceri, F | 1 |
| Benedetti, F | 1 |
| Rambaldi, A | 1 |
| Sajeva, MR | 1 |
| Tresoldi, M | 1 |
| Pileri, A | 1 |
| Bordignon, C | 1 |
| Bregni, M | 1 |
2 other studies available for thiotepa and Lymphoma, Mantle-Cell
| Article | Year |
|---|---|
Excessive toxicity of the high dose thiotepa and etoposide regimen when combined with radiation: Long-term autologous transplantation experience in follicular and mantle cell lymphoma.
Topics: Adult; Aged; Combined Modality Therapy; Etoposide; Female; Follow-Up Studies; Hematopoietic Stem Cel | 2005 |
Reduced-intensity conditioning followed by allografting of hematopoietic cells can produce clinical and molecular remissions in patients with poor-risk hematologic malignancies.
Topics: Adult; Aged; Anemia, Refractory, with Excess of Blasts; Cyclophosphamide; Cyclosporine; Female; Graf | 2002 |