thiotepa has been researched along with Leukocytopenia in 38 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thirty-five previously treated advanced breast cancer patients received 70 cycles (median, 2 cycles/patient; range, 1-6) of 1600 mg of oral sustained release pentoxifylline every 8 h for 4 doses in combination with escalating doses of i." | 2.68 | Dose escalation of N,N',N"-triethylenethiophosphoramide combined with pentoxifylline for advanced breast cancer. ( Cap, B; Dezube, BJ; Hayes, DF; Henderson, IC; Shapiro, CL; Tretyakov, O; Wright, J, 1995) |
| "ThioTEPA was administered i." | 2.67 | Phase I/pharmacokinetic reevaluation of thioTEPA. ( Cole, D; DeLap, RJ; DeVito, J; Engstrom, PF; LaCreta, F; Litwin, S; O'Dwyer, PJ; Peter, R; Poplack, D; Tartaglia, L, 1991) |
| "In the group of breast cancer patients (P T0-2N0-1M0) who received adjuvant polychemotherapy (TMF, CMF schemes) the survival rates are higher by 12." | 2.66 | Clinical trials on adjuvant chemotherapy for breast cancer. ( Barash, NJ; Bavli, JL; Kostetskaya, TV; Kremen, BV; Migmanova, NS; Moiseyenko, VM; Popova, RT; Rzhankov, SV; Seleznyov, IK; Semiglazov, VF, 1986) |
| "Fifty-eight patients with disseminated breast cancer were randomly divided into 2 study groups." | 2.66 | [Evaluation of regimens for the simultaneous and sequential administration of cytostatics in the combined chemotherapy of disseminated forms of breast cancer]. ( Borisov, AI; Korman, DB; Maslova, IA; Pines, EV, 1985) |
| "Thiotepa treatments should be limited to 90 mg/mo and protracted therapy avoided in elderly men." | 1.26 | Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma. ( Coleman, M; Hollister, D, 1980) |
| "Recurrent transitional cell carcinoma was treated with prophylactic intravesical thio-tepa in 22 cases." | 1.26 | Intravesical thio-tepa in the immediate postoperative period in patients with recurrent transitional cell carcinoma of the bladder. ( Gavrell, GJ; Leblanc, GA; Lewis, RW; Meehan, WL, 1978) |
| "Serious leukopenia was found in 2 of the 48 patients receiving the combined instillation therapy but we concluded that this was not attributable to the use of urokinase." | 1.25 | The prophylactic use of thio-tepa and urokinase in transitional cell carcinoma of the bladder: a preliminary report. ( Hisazumi, H; Misaki, T; Miyazaki, K; Naito, K; Uchibayashi, T, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (94.74) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HANKINS, GW | 1 |
| MCCARTEN, AB | 1 |
| EISMAN, SG | 1 |
| RICHARDSON, FM | 1 |
| TURBINA, IL | 2 |
| IWATA, H | 1 |
| NAKAJIMA, K | 1 |
| SANTO, H | 1 |
| Soloway, MS | 1 |
| Ford, KS | 1 |
| Hollister, D | 1 |
| Coleman, M | 1 |
| Shamberger, RC | 1 |
| Devereux, DF | 1 |
| Brennan, MF | 1 |
| Shapiro, CL | 1 |
| Dezube, BJ | 1 |
| Tretyakov, O | 1 |
| Wright, J | 1 |
| Cap, B | 1 |
| Henderson, IC | 1 |
| Hayes, DF | 1 |
| Gavrell, GJ | 1 |
| Lewis, RW | 1 |
| Meehan, WL | 1 |
| Leblanc, GA | 1 |
| Rampal, M | 1 |
| Alimi, JC | 1 |
| Pons, G | 1 |
| Fiquet, JM | 1 |
| Hisazumi, H | 1 |
| Uchibayashi, T | 1 |
| Naito, K | 1 |
| Misaki, T | 1 |
| Miyazaki, K | 1 |
| O'Dwyer, PJ | 1 |
| LaCreta, F | 1 |
| Engstrom, PF | 1 |
| Peter, R | 1 |
| Tartaglia, L | 1 |
| Cole, D | 1 |
| Litwin, S | 1 |
| DeVito, J | 1 |
| Poplack, D | 1 |
| DeLap, RJ | 1 |
| Mukaiyama, T | 1 |
| Ogawa, M | 1 |
| Horikoshi, N | 1 |
| Inoue, K | 1 |
| Fukutani, H | 1 |
| Tabata, M | 1 |
| Hirano, A | 1 |
| Mizunuma, N | 1 |
| Itami, S | 1 |
| Skeel, RT | 1 |
| Andersen, JW | 1 |
| Tormey, DC | 1 |
| Benson, AB | 1 |
| Asbury, RF | 1 |
| Falkson, G | 1 |
| Semiglazov, VF | 1 |
| Bavli, JL | 1 |
| Moiseyenko, VM | 1 |
| Rzhankov, SV | 1 |
| Migmanova, NS | 1 |
| Popova, RT | 1 |
| Seleznyov, IK | 1 |
| Kremen, BV | 1 |
| Kostetskaya, TV | 1 |
| Barash, NJ | 1 |
| Kochetkova, VA | 1 |
| Ul'chenko, VM | 1 |
| Gracheva, ZA | 1 |
| Lastochkina, VI | 1 |
| Korman, DB | 1 |
| Borisov, AI | 1 |
| Maslova, IA | 1 |
| Pines, EV | 1 |
| Lunglmayr, G | 1 |
| Czech, K | 1 |
| Zekert, F | 1 |
| Kellner, G | 1 |
| Veenema, RJ | 2 |
| Romas, NA | 1 |
| Fingerhut, B | 1 |
| Shuvaeva, NI | 1 |
| Emel'ianova, LS | 1 |
| des Roseaux, M | 1 |
| Vacant, J | 1 |
| Beurton, D | 1 |
| Cukier, J | 1 |
| Archimbaud, JP | 1 |
| Calcat, P | 1 |
| Martel, JP | 1 |
| Frid, IA | 1 |
| Oravisto, KJ | 1 |
| Alesenko, AV | 1 |
| Burlakova, EB | 1 |
| Dziuba, NM | 1 |
| Slepukhina, LV | 1 |
| Emanuél', NM | 1 |
| Livshits, MA | 1 |
| Prane, LIu | 1 |
| Cohn, I | 1 |
| Dean, AL | 1 |
| Uson, AC | 1 |
| Roberts, M | 1 |
| Longo, F | 1 |
| Saslaw, S | 1 |
| Carlisle, HN | 1 |
| Kholodnyi, MD | 1 |
| Mindlin, SS | 1 |
| Sergienko, TM | 1 |
| Guchek, IuL | 1 |
| Chernyĭ, VA | 1 |
| Levin, AO | 1 |
| Volodkovich, HG | 1 |
| Maliugina, LL | 1 |
| Pol'kina, RI | 1 |
| Remizov, AL | 1 |
| Petrov, AS | 1 |
| Kraĭz, BO | 1 |
| Riddle, PR | 1 |
| Wallace, DM | 1 |
| Heydenreich, G | 1 |
| Ansfield, FJ | 1 |
| Carter, AC | 1 |
| Goldenberg, IS | 1 |
| Segaloff, A | 1 |
2 reviews available for thiotepa and Leukocytopenia
| Article | Year |
|---|---|
The effect of chemotherapeutic agents on wound healing.
Topics: Adrenal Cortex Hormones; Anemia; Animals; Antineoplastic Agents; Azathioprine; Collagen; Cyclophosph | 1981 |
Chemotherapy for bladder cancer.
Topics: Administration, Topical; Alkylating Agents; Blood Cell Count; Carcinoma, Papillary; Cystitis; Cystos | 1974 |
5 trials available for thiotepa and Leukocytopenia
| Article | Year |
|---|---|
Dose escalation of N,N',N"-triethylenethiophosphoramide combined with pentoxifylline for advanced breast cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Dose-Response Relationship, Dr | 1995 |
Phase I/pharmacokinetic reevaluation of thioTEPA.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Leukocyte Count; Leukopenia; Male | 1991 |
Clinical trials on adjuvant chemotherapy for breast cancer.
Topics: Adult; Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Ne | 1986 |
[Evaluation of regimens for the simultaneous and sequential administration of cytostatics in the combined chemotherapy of disseminated forms of breast cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Fema | 1985 |
Complications and toxic manifestations of surgical adjuvant chemotherapy for breast cancer.
Topics: Adult; Aged; Blood Cell Count; Blood Platelets; Blood Transfusion; Breast Neoplasms; Clinical Trials | 1968 |
31 other studies available for thiotepa and Leukocytopenia
| Article | Year |
|---|---|
ADJUVANT CHEMOTHERAPY (TRIETHYLENE THIOPHOSPHORAMIDE) WITH RADICAL MASTECTOMY AND RADIOTHERAPY IN BREAST CANCER.
Topics: Breast Neoplasms; Carcinoma; Chemotherapy, Adjuvant; Humans; Leukopenia; Mastectomy; Mastectomy, Rad | 1963 |
CANCER CHEMOTHERAPY.
Topics: Adrenal Cortex Hormones; Aminopterin; Androgens; Antimetabolites; Antineoplastic Agents; Blood Plate | 1964 |
[STATE OF HEMATOPOIESIS IN PATIENTS WITH CANCER OF THE OVARIES DURING THIO-TEPA THERAPY].
Topics: Bone Marrow Examination; Female; Geriatrics; Hematopoiesis; Humans; Leukocyte Count; Leukopenia; Neo | 1964 |
[THE EFFECT OF ALPHA-THIOLA (ALPHA-MERCAPTO-PROPIONYL-GLYCINE) ON THE LEUKOPENIA INDUCED BY THE TREATMENT WITH SOME ANTICANCER AGENTS].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Glycine; Leukopenia; Mice; Pharmacology; P | 1964 |
Thiotepa-induced myelosuppression: review of 670 bladder instillations.
Topics: Adult; Aged; Female; Humans; Leukopenia; Male; Middle Aged; Thiotepa; Thrombocytopenia; Urinary Blad | 1983 |
Hematologic effects of intravesicular thiotepa therapy for bladder carcinoma.
Topics: Adult; Aged; Anemia; Blood Cell Count; Bone Marrow; Female; Hematologic Diseases; Humans; Injections | 1980 |
Intravesical thio-tepa in the immediate postoperative period in patients with recurrent transitional cell carcinoma of the bladder.
Topics: Adolescent; Adult; Aged; Animals; Carcinoma, Transitional Cell; Child; Child, Preschool; Dogs; Follo | 1978 |
[The harmfulness of intravesical instillations of thiotepa in cases of vesico-renal reflux].
Topics: Aged; Carcinoma, Transitional Cell; Humans; Leukopenia; Male; Thiotepa; Thrombocytopenia; Urinary Bl | 1978 |
The prophylactic use of thio-tepa and urokinase in transitional cell carcinoma of the bladder: a preliminary report.
Topics: Adolescent; Adult; Aged; Carcinoma, Transitional Cell; Cystitis; Drug Therapy, Combination; Endopept | 1975 |
[A study to overcome drug resistance using high-dose chemotherapy with autologous bone marrow transplantation].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Colony-Stimulati | 1989 |
Combination chemotherapy of advanced breast cancer. Comparison of dibromodulcitol, doxorubicin, vincristine, and fluoxymesterone to thiotepa, doxorubicin, vinblastine, and fluoxymesterone: an Eastern Cooperative Oncology Group Study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; | 1989 |
[Prediction of peripheral blood leukopenia during tumor chemotherapy].
Topics: Adult; Combined Modality Therapy; Female; Humans; Leukopenia; Middle Aged; Ovarian Neoplasms; Thiote | 1986 |
Bladder hyperthermia in the treatment of vesical papillomatosis.
Topics: Bacitracin; Buffers; Drug Combinations; Follow-Up Studies; Hematuria; Hot Temperature; Humans; Leuko | 1973 |
[Toxic reactions during treatment of the ovarian cancer with ThioTEPA].
Topics: Animals; Blood Cell Count; Dyspepsia; Female; Leukopenia; Ovarian Neoplasms; Thiotepa; Thrombocytope | 1974 |
[Usual harmlessness of endovesical instillations of thio-tepa].
Topics: Carcinoma, Papillary; Electrocoagulation; Humans; Leukopenia; Papilloma; Thiotepa; Thrombocytopenia; | 1973 |
[Spontaneously cured pancytopenia due to intravesical thio-tepa, apropos of one case].
Topics: Anemia; Female; Herpes Zoster; Humans; Leukopenia; Middle Aged; Mucous Membrane; Papilloma; Thiotepa | 1973 |
[The effect of anesthesia and surgical intervention on hematopoiesis following chemotherapy of malignant ovarian tumors].
Topics: Anemia; Anesthesia, Endotracheal; Cyclophosphamide; Female; Hematopoiesis; Humans; Leukopenia; Ovari | 1972 |
Optimal intravesical dosage of thio-tepa in the prophylaxis of recurrent bladder papillomatosis.
Topics: Administration, Oral; Cystoscopy; Humans; Injections; Leukopenia; Neoplasm Recurrence, Local; Papill | 1972 |
[Comparison of some biochemical and hematologic characteristics in radiation sickness and under the effects of alkylating agents for instance thioTEPA].
Topics: Alkylating Agents; Animals; Leukocyte Count; Leukocytes; Leukopenia; Lipids; Liver; Mice; Radiation | 1966 |
[On quantitative changes in the leukocytes and thrombocytes after chemotherapy in patients with malignant tumors of the ovaries].
Topics: Antineoplastic Agents; Cyclophosphamide; Female; Humans; Leukopenia; Ovarian Neoplasms; Pyrimidines; | 1966 |
[Changes in hemopoiesis of patients with cancer during chemotherapy in relation to the nutritional factor (proteins and vitamins--C and B complex].
Topics: Aged; Ascorbic Acid; Dietary Proteins; Female; Hematopoiesis; Humans; Leukopenia; Male; Middle Aged; | 1968 |
Thiotepa bladder instillations: therapy and prophylaxis for superficial bladder tumors.
Topics: Blood Platelet Disorders; Cystitis; Cystoscopy; Humans; Leukopenia; Neoplasm Recurrence, Local; Solu | 1969 |
Nonhuman primates in evaluation of hematotoxicity.
Topics: Animals; Busulfan; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug-Related Side Effects and Adver | 1969 |
[The hypoplastic state of hematopoiesis following chemotherapy with alkylating compounds].
Topics: Adult; Aged; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Female; Hematologic Disease | 1969 |
[Changes in several hematologic indices under the effects of perfusion with thio-tepa].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carcinoma, Brown-Pearce; Chemotherapy, Cancer, Regional Per | 1967 |
[The morphologic composition of peripheral blood following intra-arterial infusion of 5-fluorouracil and alkylating preparations in stomach cancer patients].
Topics: Anemia; Fluorouracil; Humans; Leukopenia; Melphalan; Nitrogen Mustard Compounds; Stomach Neoplasms; | 1970 |
[Clinico-electrocardiographic changes during perfusion chemotherapy of malignant tumors of the extremities].
Topics: Adolescent; Adult; Aged; Anemia; Cardiomyopathies; Chemotherapy, Cancer, Regional Perfusion; Child; | 1970 |
[The anti-tumor effect of several mono- and di-chlor-sym.triazine derivatives].
Topics: Animals; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Female; Leukopenia; Lung Neoplasms; Lympho | 1970 |
Intracavitary chemotherapy for multiple non-invasive bladder tumours.
Topics: Alkylating Agents; Carcinoma, Papillary; Humans; Leukopenia; Neoplasm Recurrence, Local; Thiotepa; U | 1971 |
Topical treatment of psoriasis with triethylenethiophosphoramide (Thio-Tepa).
Topics: Adult; Aged; Biopsy; Blood Cell Count; Blood Platelets; Chronic Disease; Female; Humans; Leukocyte C | 1971 |
Phase I study of phenesterin (NSC-104469).
Topics: Administration, Oral; Adult; Aged; Androgens; Antineoplastic Agents; Blood Cell Count; Blood Platele | 1971 |