Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
| Article | Year |
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In the search for new anticancer drugs. 17. Linear and cyclic polyether analogues of N,N:N',N':N'',N''-tri-1,2-ethanediylphosphoric triamide and N,N:N',N':N'',N''-tri-1,2-ethanediylphosphorothioic triamide.Journal of medicinal chemistry, 1986, Volume: 29, Issue:7
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemia P388 | 1986 |
In the search for new anticancer drugs. 9. Synthesis and anticancer activity of spin-labeled analogues of N,N:N',N':N",N"-Tri-1,2-ethanediylphosphoric triamide and N,N:N',N':N",N"-tri-1,2-ethanediylphosphorothioic triamide.Journal of medicinal chemistry, 1984, Volume: 27, Issue:6
Topics: Animals; Antineoplastic Agents; Azirines; Leukemia P388; Male; Mice; Structure-Activity Relationship | 1984 |
In the search for new anticancer drugs. 26. A comparison of anticancer activities of several TEPA, thio-TEPA, Seleno-TEPA, and azetidine analogs, including congeners containing an aminoxyl moiety.Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:7
Topics: Animals; Antineoplastic Agents; Azetidines; Chemical Phenomena; Chemistry, Physical; Drug Screening | 1994 |
In the search for new anticancer drugs. XX: A comparison of the in vitro growth inhibition of P388 cells by TEPA and N,N;N',N'-bis (1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl-4- piperidinylaminocarbonyl) phosphoric triamide and congeners.Cancer letters, 1987, Volume: 34, Issue:1
Topics: Animals; Antineoplastic Agents; Azirines; Cell Line; Leukemia P388; Leukemia, Experimental; Structur | 1987 |
In the search for new anticancer drugs. X. N,N; N',N'-bis(1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl- 4-piperidinylaminocarbonyl) phosphoric triamide--a new potential anticancer drug of high activity and low toxicity.Life sciences, 1985, Apr-15, Volume: 36, Issue:15
Topics: Animals; Antineoplastic Agents; Azirines; Lethal Dose 50; Leukemia L1210; Leukemia P388; Male; Mice; | 1985 |
Cellular pharmacology of N,N',N''-triethylene thiophosphoramide.Cancer letters, 1988, Aug-15, Volume: 41, Issue:2
Topics: Animals; Cell Division; Cell Survival; DNA Replication; DNA, Neoplasm; Kinetics; Leucine; Leukemia P | 1988 |