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thiotepa and Leukemia P388

thiotepa has been researched along with Leukemia P388 in 6 studies

Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.

Research Excerpts

ExcerptRelevanceReference
" The LD50 of 5 is 270 mg/kg, while that of Thio-TEPA is 18 mg/kg."1.27In the search for new anticancer drugs. X. N,N; N',N'-bis(1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl- 4-piperidinylaminocarbonyl) phosphoric triamide--a new potential anticancer drug of high activity and low toxicity. ( Li, SW; Sosnovsky, G, 1985)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19905 (83.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sosnovsky, G6
Lukszo, J2
Rao, NU3
Paul, BD1
Konieczny, M1
Purgstaller, K1
Laib, F1
Miller, B2
Gutierrez, PL2
Li, SW1
Tenenholz, T1
Egorin, MJ1

Other Studies

6 other studies available for thiotepa and Leukemia P388

ArticleYear
In the search for new anticancer drugs. 17. Linear and cyclic polyether analogues of N,N:N',N':N'',N''-tri-1,2-ethanediylphosphoric triamide and N,N:N',N':N'',N''-tri-1,2-ethanediylphosphorothioic triamide.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:7

    Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemia P388

1986
In the search for new anticancer drugs. 9. Synthesis and anticancer activity of spin-labeled analogues of N,N:N',N':N",N"-Tri-1,2-ethanediylphosphoric triamide and N,N:N',N':N",N"-tri-1,2-ethanediylphosphorothioic triamide.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:6

    Topics: Animals; Antineoplastic Agents; Azirines; Leukemia P388; Male; Mice; Structure-Activity Relationship

1984
In the search for new anticancer drugs. 26. A comparison of anticancer activities of several TEPA, thio-TEPA, Seleno-TEPA, and azetidine analogs, including congeners containing an aminoxyl moiety.
    Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:7

    Topics: Animals; Antineoplastic Agents; Azetidines; Chemical Phenomena; Chemistry, Physical; Drug Screening

1994
In the search for new anticancer drugs. XX: A comparison of the in vitro growth inhibition of P388 cells by TEPA and N,N;N',N'-bis (1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl-4- piperidinylaminocarbonyl) phosphoric triamide and congeners.
    Cancer letters, 1987, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Azirines; Cell Line; Leukemia P388; Leukemia, Experimental; Structur

1987
In the search for new anticancer drugs. X. N,N; N',N'-bis(1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl- 4-piperidinylaminocarbonyl) phosphoric triamide--a new potential anticancer drug of high activity and low toxicity.
    Life sciences, 1985, Apr-15, Volume: 36, Issue:15

    Topics: Animals; Antineoplastic Agents; Azirines; Lethal Dose 50; Leukemia L1210; Leukemia P388; Male; Mice;

1985
Cellular pharmacology of N,N',N''-triethylene thiophosphoramide.
    Cancer letters, 1988, Aug-15, Volume: 41, Issue:2

    Topics: Animals; Cell Division; Cell Survival; DNA Replication; DNA, Neoplasm; Kinetics; Leucine; Leukemia P

1988