thiotepa has been researched along with Leukemia L 1210 in 13 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "ThioTEPA was greater than 85% consumed by the microsomal incubation conditions employed, and TEPA was the only product of the microsomal metabolism of thioTEPA." | 1.28 | Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA. ( Ashar, B; Cohen, NA; Egorin, MJ; Hilton, J; Pan, SS; Ross, DD; Snyder, SW; Wietharn, BE, 1991) |
| " The LD50 of 5 is 270 mg/kg, while that of Thio-TEPA is 18 mg/kg." | 1.27 | In the search for new anticancer drugs. X. N,N; N',N'-bis(1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl- 4-piperidinylaminocarbonyl) phosphoric triamide--a new potential anticancer drug of high activity and low toxicity. ( Li, SW; Sosnovsky, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Selassie, CD | 1 |
| Hansch, C | 1 |
| Khwaja, TA | 1 |
| Li, Y | 1 |
| Eiseman, JL | 1 |
| Sentz, DL | 1 |
| Rogers, FA | 1 |
| Pan, SS | 4 |
| Hu, LT | 1 |
| Egorin, MJ | 6 |
| Callery, PS | 1 |
| RUTMAN, RJ | 1 |
| Barret, JM | 1 |
| Etiévant, C | 1 |
| Fahy, J | 1 |
| Lhomme, J | 1 |
| Hill, BT | 1 |
| Iaremenko, KV | 1 |
| Eremeeva, AA | 1 |
| Tereshin, IM | 1 |
| Cohen, NA | 1 |
| Snyder, SW | 5 |
| Ashar, B | 1 |
| Wietharn, BE | 2 |
| Ross, DD | 1 |
| Hilton, J | 1 |
| Daly, C | 2 |
| Sosnovsky, G | 2 |
| Li, SW | 2 |
| Noell, CW | 1 |
| Cheng, CC | 1 |
13 other studies available for thiotepa and Leukemia L 1210
| Article | Year |
|---|---|
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; | 1990 |
Synthesis and antitumor evaluation of a highly potent cytotoxic DNA cross-linking polyamine analogue, 1,12-diaziridinyl-4,9-diazadodecane.
Topics: Animals; Antineoplastic Agents; Aziridines; Cross-Linking Reagents; DNA; Electrophoresis, Agar Gel; | 1996 |
EXPERIMENTAL CHEMOTHERAPY STUDIES. V. THE COLLATERAL SENSITIVITY TO ALKYLATING AGENTS OF SEVERAL ANTIMETABOLITE-RESISTANT ASCITES TUMORS IN MICE.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ascites; Azaserine; Carcinoma, E | 1964 |
Novel artificial endonucleases inhibit base excision repair and potentiate the cytotoxicity of DNA-damaging agents on L1210 cells.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Base Pairing; Carmustine; D | 1999 |
[Potentiation of the antitumor action of alkylating compounds by amphotericin B].
Topics: Alkylating Agents; Amphotericin B; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cycloph | 1977 |
Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA.
Topics: Animals; Aroclors; Biotransformation; Cell Division; Cell Line; Chlorodiphenyl (54% Chlorine); DNA D | 1991 |
Cellular transport and accumulation of thiotepa.
Topics: Animals; Biological Transport; Birds; Cell Membrane Permeability; Erythrocytes; Half-Life; Humans; L | 1990 |
Characterization of nonexchangeable radioactivity in L1210 cells incubated with [14C]thiotepa: labeling of phosphatidylethanolamine.
Topics: Animals; Carbon Radioisotopes; Cell Nucleus; Chromatography, Thin Layer; Leukemia L1210; Phosphatidy | 1990 |
Effects of ethanolamine and choline on thiotepa cellular accumulation and cytotoxicity in L1210 cells.
Topics: Animals; Carbon Radioisotopes; Cell Survival; Choline; Ethanolamine; Ethanolamines; Kinetics; Leukem | 1990 |
Cellular transport and accumulation of thiotepa in murine, human, and avian cells.
Topics: Animals; Biological Transport; Biotransformation; Cell Membrane Permeability; Humans; Kinetics; Leuk | 1989 |
In the search for new anticancer drugs XI. Anticancer activity of nitroxyl labeled phosphoric N,N;N',N';N",N"-tris[1,2-ethanediyl]triamide(TEPA) and phosphorothioic N,N;N',N';N",N"-tris[1,2-ethanediyl]triamide(thio-TEPA) derivatives.
Topics: Animals; Antineoplastic Agents; Azirines; Drug Evaluation, Preclinical; Leukemia L1210; Male; Mice; | 1985 |
In the search for new anticancer drugs. X. N,N; N',N'-bis(1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl- 4-piperidinylaminocarbonyl) phosphoric triamide--a new potential anticancer drug of high activity and low toxicity.
Topics: Animals; Antineoplastic Agents; Azirines; Lethal Dose 50; Leukemia L1210; Leukemia P388; Male; Mice; | 1985 |
Anticancer activity of P,P-bis(2-methyl-1-aziridinyl)-N-2-pyrimidinylphosphinic amide (methylphosphazine) and related compounds.
Topics: Adenocarcinoma; Amides; Animals; Antineoplastic Agents; Azirines; Carcinoma 256, Walker; Cyclophosph | 1968 |