thiotepa has been researched along with Intradural-Extramedullary Spinal Cord Neoplasms in 3 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between April 1986 and March 1989, ten patients under 21 years of age with histologically confirmed malignant astrocytoma, received marrow-ablative chemotherapy with either thiotepa and Etoposide (five patients) or thiotepa, Etoposide and BCNU (five patients), followed by bone marrow 'rescue'." | 5.06 | High-dose multi-agent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence. ( August, C; Bayever, E; Finlay, JL; Freid, A; Kamani, N; Kramer, E; Packer, R; Rorke, L; Sutton, L; Zimmerman, R, 1990) |
| "Twelve had Burkitt's leukemia/lymphoma." | 2.39 | Excessive spinal cord toxicity from intensive central nervous system-directed therapies. ( Frierdich, S; Lee, Y; Moertel, CL; Morse, M; Nieder, M; Priest, JR; Toogood, I; Watterson, J, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thorarinsdottir, HK | 1 |
| Rood, B | 1 |
| Kamani, N | 2 |
| Lafond, D | 1 |
| Perez-Albuerne, E | 1 |
| Loechelt, B | 1 |
| Packer, RJ | 1 |
| MacDonald, TJ | 1 |
| Watterson, J | 1 |
| Toogood, I | 1 |
| Nieder, M | 1 |
| Morse, M | 1 |
| Frierdich, S | 1 |
| Lee, Y | 1 |
| Moertel, CL | 1 |
| Priest, JR | 1 |
| Finlay, JL | 1 |
| August, C | 1 |
| Packer, R | 1 |
| Zimmerman, R | 1 |
| Sutton, L | 1 |
| Freid, A | 1 |
| Rorke, L | 1 |
| Bayever, E | 1 |
| Kramer, E | 1 |
1 review available for thiotepa and Intradural-Extramedullary Spinal Cord Neoplasms
| Article | Year |
|---|---|
Excessive spinal cord toxicity from intensive central nervous system-directed therapies.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, P | 1994 |
1 trial available for thiotepa and Intradural-Extramedullary Spinal Cord Neoplasms
| Article | Year |
|---|---|
High-dose multi-agent chemotherapy followed by bone marrow 'rescue' for malignant astrocytomas of childhood and adolescence.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bone Marrow Transplantation | 1990 |
1 other study available for thiotepa and Intradural-Extramedullary Spinal Cord Neoplasms
| Article | Year |
|---|---|
Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child, Preschool; Cisp | 2007 |