thiotepa has been researched along with Hemorrhage in 10 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Hemorrhage: Bleeding or escape of blood from a vessel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paclitaxel, an effective chemotherapeutic agent in the management of breast carcinoma, may have activity in women whose disease has recurred after high dose chemotherapy." | 9.08 | A Phase I dose escalation trial of continuous infusion paclitaxel to augment high dose cyclophosphamide and thiotepa plus stem cell rescue for the treatment of patients with advanced breast carcinoma. ( Grinblatt, DL; Malloy, R; Williams, SF; Zimmerman, TM, 1998) |
| "A case of nearly exsanguinating bladder hemorrhage, occurring six months after intravesical thiotepa administration, is reported." | 7.67 | Intractable bladder hemorrhage requiring cystectomy after use of intravesical thiotepa. ( Friedman, NB; Kasimain, D; Kern, WH; Skinner, D; Treible, DP, 1987) |
| "Paclitaxel, an effective chemotherapeutic agent in the management of breast carcinoma, may have activity in women whose disease has recurred after high dose chemotherapy." | 5.08 | A Phase I dose escalation trial of continuous infusion paclitaxel to augment high dose cyclophosphamide and thiotepa plus stem cell rescue for the treatment of patients with advanced breast carcinoma. ( Grinblatt, DL; Malloy, R; Williams, SF; Zimmerman, TM, 1998) |
| "A case of nearly exsanguinating bladder hemorrhage, occurring six months after intravesical thiotepa administration, is reported." | 3.67 | Intractable bladder hemorrhage requiring cystectomy after use of intravesical thiotepa. ( Friedman, NB; Kasimain, D; Kern, WH; Skinner, D; Treible, DP, 1987) |
| " The toxic death rate was 1%." | 1.32 | Toxicity of the high-dose chemotherapy CTC regimen (cyclophosphamide, thiotepa, carboplatin): the Netherlands Cancer Institute experience. ( Baars, JW; Holtkamp, MJ; Rodenhuis, S; Schornagel, JH; Schrama, JG, 2003) |
| "Serious leukopenia was found in 2 of the 48 patients receiving the combined instillation therapy but we concluded that this was not attributable to the use of urokinase." | 1.25 | The prophylactic use of thio-tepa and urokinase in transitional cell carcinoma of the bladder: a preliminary report. ( Hisazumi, H; Misaki, T; Miyazaki, K; Naito, K; Uchibayashi, T, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schrama, JG | 1 |
| Holtkamp, MJ | 1 |
| Baars, JW | 1 |
| Schornagel, JH | 1 |
| Rodenhuis, S | 1 |
| MATSUOKA, M | 1 |
| ZEZZANETO, L | 1 |
| SOERENSEN, B | 1 |
| SALIBA, AM | 1 |
| CORREA, HC | 1 |
| ROGERS, LS | 1 |
| Fleming, RA | 1 |
| Cruz, JM | 1 |
| Webb, CD | 1 |
| Kucera, GL | 1 |
| Perry, JJ | 1 |
| Hurd, DD | 1 |
| Zimmerman, TM | 1 |
| Grinblatt, DL | 1 |
| Malloy, R | 1 |
| Williams, SF | 1 |
| Hisazumi, H | 1 |
| Uchibayashi, T | 1 |
| Naito, K | 1 |
| Misaki, T | 1 |
| Miyazaki, K | 1 |
| Treible, DP | 1 |
| Skinner, D | 1 |
| Kasimain, D | 1 |
| Friedman, NB | 1 |
| Kern, WH | 1 |
| Shnittser, IuM | 1 |
| Andriukin, AA | 1 |
| Vinogradova, ON | 1 |
| Akhtomova, LV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Randomized Feasibility and Phase II Adjuvant Breast Cancer Study of the Netherlands Working Party for Autotransplantation in Solid Tumors.[NCT00851110] | Phase 2 | 50 participants (Anticipated) | Interventional | 2004-10-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for thiotepa and Hemorrhage
| Article | Year |
|---|---|
Urinary elimination of cyclophosphamide alkylating metabolites and free thiols following two administration schedules of high-dose cyclophosphamide and mesna.
Topics: Adult; Antineoplastic Agents, Alkylating; Carboplatin; Cyclophosphamide; Cystitis; Drug Administrati | 1996 |
A Phase I dose escalation trial of continuous infusion paclitaxel to augment high dose cyclophosphamide and thiotepa plus stem cell rescue for the treatment of patients with advanced breast carcinoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined | 1998 |
8 other studies available for thiotepa and Hemorrhage
| Article | Year |
|---|---|
Toxicity of the high-dose chemotherapy CTC regimen (cyclophosphamide, thiotepa, carboplatin): the Netherlands Cancer Institute experience.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Carboplatin; C | 2003 |
[IMPROVEMENT AND EXACERBATION IN LEUKEMIA].
Topics: Aminocaproates; Aminocaproic Acid; Anemia; Antineoplastic Agents; Blood Transfusion; Busulfan; Centr | 1963 |
[STUDY OF VARIOUS ORGANIC CHANGES PRODUCED BY ANTIBLASTIC CHEMOTHERAPY ADMINISTERED TO DOGS IN HIGH DOSES].
Topics: Dogs; Gastrointestinal Hemorrhage; Hemorrhage; Pathology; Pharmacology; Research; Thiotepa; Toxicolo | 1963 |
CANCER CHEMOTHERAPY BY CONTINUOUS INTRA-ARTERIAL INFUSION. EXPERIENCE OF THE VETERANS ADMINISTRATION SURGICAL ADJUVANT CANCER CHEMOTHERAPY INFUSION STUDY GROUP.
Topics: Floxuridine; Geriatrics; Hemiplegia; Hemorrhage; Infusions, Intra-Arterial; Infusions, Parenteral; L | 1964 |
The prophylactic use of thio-tepa and urokinase in transitional cell carcinoma of the bladder: a preliminary report.
Topics: Adolescent; Adult; Aged; Carcinoma, Transitional Cell; Cystitis; Drug Therapy, Combination; Endopept | 1975 |
Intractable bladder hemorrhage requiring cystectomy after use of intravesical thiotepa.
Topics: Administration, Intravesical; Aged; Carcinoma, Papillary; Hemorrhage; Humans; Male; Thiotepa; Urinar | 1987 |
[Effect of blood loss during mastectomy on endurance of radiation and chemotherapy].
Topics: Adult; Aged; Breast Neoplasms; Female; Hemorrhage; Humans; Male; Mastectomy; Middle Aged; Thiotepa | 1968 |
[Adverse effect of thio tepa on the hemopoiesis and complications arising with it].
Topics: Female; Hematopoiesis; Hemorrhage; Humans; Middle Aged; Thiotepa | 1968 |