thiotepa has been researched along with Heart Failure in 6 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We combined paclitaxel, melphalan and high-dose cyclophosphamide, thiotepa, and carboplatin in a triple sequential high-dose regimen for patients with metastatic breast cancer." | 5.11 | Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer. ( Hesdorffer, C; Horwich, T; Jacobson, C; Savage, D; Tiersten, A; Troxel, A; Weitzman, A; Wo, J, 2004) |
| "Thiotepa (TT) has not been reported to cause cardiomyopathy, whereas cyclophosphamide (Cy)-related cardiomyopathy is well characterized." | 1.30 | Thiotepa-associated cardiomyopathy during blood or marrow transplantation: association with the female sex and cardiac risk factors. ( Alidina, A; Anderson, B; Baer, MR; Bambach, B; Barcos, MP; Bernstein, SH; Czuczman, MS; Ford, LA; Lawrence, D; McCarthy, PL; Proulx, GM; Slack, JL; Spangenthal, E; Wetzler, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, X | 1 |
| Deng, S | 1 |
| Liu, L | 2 |
| GOLDMAN, BS | 1 |
| PEARSON, FG | 1 |
| Tiersten, A | 1 |
| Wo, J | 1 |
| Jacobson, C | 1 |
| Weitzman, A | 1 |
| Horwich, T | 1 |
| Hesdorffer, C | 1 |
| Savage, D | 1 |
| Troxel, A | 1 |
| Alidina, A | 1 |
| Lawrence, D | 1 |
| Ford, LA | 1 |
| Baer, MR | 1 |
| Bambach, B | 1 |
| Bernstein, SH | 1 |
| Czuczman, MS | 1 |
| Slack, JL | 1 |
| Spangenthal, E | 1 |
| Wetzler, M | 1 |
| Barcos, MP | 1 |
| Proulx, GM | 1 |
| Anderson, B | 1 |
| McCarthy, PL | 1 |
| Fujimaki, K | 1 |
| Maruta, A | 1 |
| Yoshida, M | 1 |
| Sakai, R | 1 |
| Tanabe, J | 1 |
| Koharazawa, H | 1 |
| Kodama, F | 1 |
| Asahina, S | 1 |
| Minamizawa, M | 1 |
| Matsuzaki, M | 1 |
| Fujisawa, S | 1 |
| Kanamori, H | 1 |
| Ishigatsubo, Y | 1 |
| Ellis, ED | 1 |
| Williams, SF | 1 |
| Moormeier, JA | 1 |
| Kaminer, LS | 1 |
| Bitran, JD | 1 |
2 trials available for thiotepa and Heart Failure
| Article | Year |
|---|---|
Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brea | 2004 |
A phase I-II study of high-dose cyclophosphamide, thiotepa and escalating doses of mitoxantrone with autologous stem cell rescue in patients with refractory malignancies.
Topics: Actuarial Analysis; Chicago; Cyclophosphamide; Drug Evaluation; Heart Failure; Hematopoietic Stem Ce | 1990 |
4 other studies available for thiotepa and Heart Failure
| Article | Year |
|---|---|
Sieve estimation in semiparametric modeling of longitudinal data with informative observation times.
Topics: Aged; Computer Simulation; Female; Heart Failure; Humans; Least-Squares Analysis; Longitudinal Studi | 2014 |
MALIGNANT PERICARDIAL EFFUSION. REVIEW OF HOSPITAL EXPERIENCE AND REPORT OF A CASE SUCCESSFULLY TREATED BY TALC POUDRAGE.
Topics: Breast Neoplasms; Cardiac Surgical Procedures; Cardiac Tamponade; Drug Therapy; Exudates and Transud | 1965 |
Thiotepa-associated cardiomyopathy during blood or marrow transplantation: association with the female sex and cardiac risk factors.
Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Blood Transfusion; Bone Marrow Transplantation; C | 1999 |
Severe cardiac toxicity in hematological stem cell transplantation: predictive value of reduced left ventricular ejection fraction.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response R | 2001 |