thiotepa has been researched along with Heart Diseases in 7 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-four adults with malignant lymphoma at high-risk for relapse were treated on a Phase I-II study of high-dose thiotepa (THIO), busulfan (BU) and cyclophosphamide (CYC) with autologous marrow or peripheral blood stem cell support." | 9.08 | A phase I-II study of high-dose thiotepa, busulfan and cyclophosphamide as a preparative regimen for autologous transplantation for malignant lymphoma. ( Diener, K; Dimopoulos, M; Giralt, S; Hagemeister, F; Ippoliti, C; Khouri, I; Mehra, R; Nath, R; Przepiorka, D; Samuels, B, 1995) |
| "Thirty-four adults with malignant lymphoma at high-risk for relapse were treated on a Phase I-II study of high-dose thiotepa (THIO), busulfan (BU) and cyclophosphamide (CYC) with autologous marrow or peripheral blood stem cell support." | 5.08 | A phase I-II study of high-dose thiotepa, busulfan and cyclophosphamide as a preparative regimen for autologous transplantation for malignant lymphoma. ( Diener, K; Dimopoulos, M; Giralt, S; Hagemeister, F; Ippoliti, C; Khouri, I; Mehra, R; Nath, R; Przepiorka, D; Samuels, B, 1995) |
| " The following protocols are proposed: CIRP (colchicine in recurrent pericarditis)--colchicine vs placebo in chronic/recurring pericarditis without pericardiocentesis; TRIPE (triamcinolone in pericardial effusion)--intrapericardial instillation of triamcinolone + 6 months colchicine vs pericardial puncture without instillation + 6 months colchicine; NEPIN (neoplastic effusion and pericardial instillation)--pericardiocentesis and drainage + intrapericardial instillation of cisplatin or thiotepa." | 3.70 | New directions in diagnosis and treatment of pericardial disease. A project of the Taskforce on Pericardial Disease of the World Heart Federation. ( Maisch, B; Ristić, AD; Seferovic, PM, 2000) |
| "A 19-year-old man with systemic sclerosis (SSc) was hospitalized for autologous peripheral blood stem cell transplantation (auto-PBSCT) due to progressive scleroderma and cardiac involvement despite conventional treatment." | 1.33 | Successful autologous peripheral blood stem cell transplantation using thiotepa in a patient with systemic sclerosis and cardiac involvement. ( Fujishima, N; Hirokawa, M; Horiuchi, T; Kawabata, Y; Komatsuda, A; Kume, M; Motegi, M; Ozawa, M; Sawada, K; Wakui, H; Yamaguchi, A, 2006) |
| "There were three atrial arrhythmias, two ventricular arrhythmias, and four atrioventricular (AV)-block episodes." | 1.31 | Cardiac conduction abnormalities in patients with breast cancer undergoing high-dose chemotherapy and stem cell transplantation. ( Adachi, I; Ando, M; Kawahigashi, N; Kobayashi, Y; Mineishi, S; Narabayashi, M; Sawada, J; Takaue, Y; Takeyama, K; Tanosaki, R; Tobinai, K; Togitani, K; Watanabe, T; Yokozawa, T, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Henes, JC | 1 |
| Koetter, I | 1 |
| Horger, M | 1 |
| Schmalzing, M | 1 |
| Mueller, K | 1 |
| Eick, C | 1 |
| Bauer, A | 1 |
| Vogel, W | 1 |
| Kanz, L | 1 |
| TOURNEUR, R | 1 |
| GRIVAUX, M | 1 |
| LAMOTTE-BARRILLON, S | 1 |
| Komatsuda, A | 1 |
| Kawabata, Y | 1 |
| Horiuchi, T | 1 |
| Motegi, M | 1 |
| Ozawa, M | 1 |
| Fujishima, N | 1 |
| Kume, M | 1 |
| Hirokawa, M | 1 |
| Wakui, H | 1 |
| Yamaguchi, A | 1 |
| Sawada, K | 1 |
| Przepiorka, D | 1 |
| Nath, R | 1 |
| Ippoliti, C | 1 |
| Mehra, R | 1 |
| Hagemeister, F | 1 |
| Diener, K | 1 |
| Dimopoulos, M | 1 |
| Giralt, S | 1 |
| Khouri, I | 1 |
| Samuels, B | 1 |
| Ando, M | 1 |
| Yokozawa, T | 1 |
| Sawada, J | 1 |
| Takaue, Y | 1 |
| Togitani, K | 1 |
| Kawahigashi, N | 1 |
| Narabayashi, M | 1 |
| Takeyama, K | 1 |
| Tanosaki, R | 1 |
| Mineishi, S | 1 |
| Kobayashi, Y | 1 |
| Watanabe, T | 1 |
| Adachi, I | 1 |
| Tobinai, K | 1 |
| Maisch, B | 1 |
| Ristić, AD | 1 |
| Seferovic, PM | 1 |
| Winer, EP | 1 |
| Burstein, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Highdose Chemotherapy and Transplantation of 34+ Selected Stem Cell for Progressive Systemic Sclerosis - Modification According to Manifestation[NCT01895244] | Phase 2 | 44 participants (Actual) | Interventional | 2012-09-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thiotepa and Heart Diseases
| Article | Year |
|---|---|
New combinations with Herceptin in metastatic breast cancer.
Topics: Anastrozole; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormo | 2001 |
1 trial available for thiotepa and Heart Diseases
| Article | Year |
|---|---|
A phase I-II study of high-dose thiotepa, busulfan and cyclophosphamide as a preparative regimen for autologous transplantation for malignant lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; Chemic | 1995 |
5 other studies available for thiotepa and Heart Diseases
| Article | Year |
|---|---|
Autologous stem cell transplantation with thiotepa-based conditioning in patients with systemic sclerosis and cardiac manifestations.
Topics: Adult; Autoimmune Diseases; Comorbidity; Cyclophosphamide; Defibrillators, Implantable; Dose-Respons | 2014 |
[DIGESTIVE INTOLERANCE TO DIGITALIN, CYTOSTATIC DRUGS AND VARIOUS THERAPEUTIC DRUGS. THEIR TREATMENT WITH METHOCLOPRAMIDE].
Topics: Antiemetics; Antitubercular Agents; Cobalt Isotopes; Cyclophosphamide; Cytostatic Agents; Digitalis | 1964 |
Successful autologous peripheral blood stem cell transplantation using thiotepa in a patient with systemic sclerosis and cardiac involvement.
Topics: Adult; Antineoplastic Agents, Alkylating; Cyclophosphamide; Heart Diseases; Humans; Male; Myeloablat | 2006 |
Cardiac conduction abnormalities in patients with breast cancer undergoing high-dose chemotherapy and stem cell transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Breast Neoplasms; Combi | 2000 |
New directions in diagnosis and treatment of pericardial disease. A project of the Taskforce on Pericardial Disease of the World Heart Federation.
Topics: Chronic Disease; Cisplatin; Clinical Trials as Topic; Colchicine; Heart Diseases; Heart Neoplasms; H | 2000 |