thiotepa has been researched along with HbS Disease in 5 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thiotepa has improved engraftment when added to this regimen, however the minimum effective dose (MED) of thiotepa to achieve engraftment while minimizing toxicities has not been well established." | 1.91 | Feasibility study of busulfan, fludarabine, and thiotepa conditioning regimen for allogeneic hematopoietic stemcell transplantationfor children and young adults with nonmalignant disorders. ( Cascio, E; Castillo, P; Farhadfar, N; Fort, J; Fraser, A; Horn, B; Lamba, J; Moore-Higgs, G; Slayton, W, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fraser, A | 1 |
| Castillo, P | 1 |
| Cascio, E | 1 |
| Moore-Higgs, G | 1 |
| Farhadfar, N | 1 |
| Fort, J | 1 |
| Slayton, W | 1 |
| Lamba, J | 1 |
| Horn, B | 1 |
| Abraham, A | 1 |
| Cluster, A | 1 |
| Jacobsohn, D | 1 |
| Delgado, D | 1 |
| Hulbert, ML | 1 |
| Kukadiya, D | 1 |
| Murray, L | 1 |
| Shenoy, S | 1 |
| Frangoul, H | 1 |
| Evans, M | 1 |
| Isbell, J | 1 |
| Bruce, K | 1 |
| Domm, J | 1 |
| de la Fuente, J | 1 |
| Dhedin, N | 1 |
| Koyama, T | 1 |
| Bernaudin, F | 2 |
| Kuentz, M | 1 |
| Karnik, L | 1 |
| Socié, G | 1 |
| Culos, KA | 1 |
| Brodsky, RA | 1 |
| DeBaun, MR | 1 |
| Kassim, AA | 1 |
| Miniero, R | 1 |
| Rocha, V | 1 |
| Saracco, P | 1 |
| Locatelli, F | 1 |
| Brichard, B | 1 |
| Nagler, A | 1 |
| Roberts, I | 1 |
| Yaniv, I | 1 |
| Beksac, M | 1 |
| Gluckman, E | 1 |
3 trials available for thiotepa and HbS Disease
| Article | Year |
|---|---|
Unrelated Umbilical Cord Blood Transplantation for Sickle Cell Disease Following Reduced-Intensity Conditioning: Results of a Phase I Trial.
Topics: Alemtuzumab; Anemia, Sickle Cell; Calcineurin Inhibitors; Child; Child, Preschool; Cord Blood Stem C | 2017 |
Haploidentical Bone Marrow Transplantation with Post-Transplantation Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Sickle Cell Anemia: Results of an International Learning Collaborative.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Antineoplastic Agents, Alkylating; Bone Marrow Transplantati | 2019 |
Cord blood transplantation (CBT) in hemoglobinopathies. Eurocord.
Topics: Anemia, Sickle Cell; Antineoplastic Agents, Alkylating; beta-Thalassemia; Child; Child, Preschool; C | 1998 |
2 other studies available for thiotepa and HbS Disease
| Article | Year |
|---|---|
Feasibility study of busulfan, fludarabine, and thiotepa conditioning regimen for allogeneic hematopoietic stemcell transplantationfor children and young adults with nonmalignant disorders.
Topics: Anemia, Sickle Cell; Busulfan; Child; Feasibility Studies; Hematopoietic Stem Cell Transplantation; | 2023 |
Haploidentical hematopoietic stem cell transplant for patients with sickle cell disease using thiotepa, fludarabine, thymoglobulin, low dose cyclophosphamide, 200 cGy tbi and post transplant cyclophosphamide.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Antilymphocyte Serum; Child; Cyclophosphamide; Female; Hemat | 2018 |