thiotepa has been researched along with Granulocytic Leukemia in 21 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, we developed an individualised fluorouracil, epirubicin, cyclophosphamide (FEC) regimen to improve outcomes in patients with high-risk early breast cancer." | 9.09 | Tailored fluorouracil, epirubicin, and cyclophosphamide compared with marrow-supported high-dose chemotherapy as adjuvant treatment for high-risk breast cancer: a randomised trial. Scandinavian Breast Group 9401 study. ( Anker, G; Bengtsson, NO; Bergh, J; Blomqvist, C; Erikstein, B; Holte, H; Kellokumpu-Lehtinen, P; Lidbrink, E; Lindman, H; Ljungman, P; Malmström, P; Nilsson, J; Ottosson, S; Salminen, E; Söderlund, G; Wiklund, T; Wilking, N; Wist, E, 2000) |
| "The incidence of secondary myelodysplasia/acute myeloid leukemia (AML) was retrospectively assessed in an international joint study in 305 node-positive breast cancer patients, who received mitoxantrone-based high-dose chemotherapy (HDCT) followed by autologous stem cell support as adjuvant therapy." | 8.82 | Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients. ( Damon, L; Demirer, T; Derigs, G; Ferrante, P; Kröger, N; Rosti, G; Wandt, H; Zander, AR, 2003) |
| " Therefore, we developed an individualised fluorouracil, epirubicin, cyclophosphamide (FEC) regimen to improve outcomes in patients with high-risk early breast cancer." | 5.09 | Tailored fluorouracil, epirubicin, and cyclophosphamide compared with marrow-supported high-dose chemotherapy as adjuvant treatment for high-risk breast cancer: a randomised trial. Scandinavian Breast Group 9401 study. ( Anker, G; Bengtsson, NO; Bergh, J; Blomqvist, C; Erikstein, B; Holte, H; Kellokumpu-Lehtinen, P; Lidbrink, E; Lindman, H; Ljungman, P; Malmström, P; Nilsson, J; Ottosson, S; Salminen, E; Söderlund, G; Wiklund, T; Wilking, N; Wist, E, 2000) |
| "The incidence of secondary myelodysplasia/acute myeloid leukemia (AML) was retrospectively assessed in an international joint study in 305 node-positive breast cancer patients, who received mitoxantrone-based high-dose chemotherapy (HDCT) followed by autologous stem cell support as adjuvant therapy." | 4.82 | Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients. ( Damon, L; Demirer, T; Derigs, G; Ferrante, P; Kröger, N; Rosti, G; Wandt, H; Zander, AR, 2003) |
| "Thiotepa has excellent antileukemic and immunosuppressive activity, and could therefore be a useful drug in the conditioning regimen for patients with advanced hematologic neoplasms." | 2.71 | Thiotepa and fractionated TBI conditioning prior to allogeneic stem cell transplantation for advanced hematologic malignancies: a phase II single institution trial. ( Beall, CL; Bunner, P; Devetten, MP; Ericson, SG; Lynch, JP; Qazilbash, MH; Weisenborn, R, 2004) |
| "At the age of 84, chronic myelogenous leukemia (CML) developed." | 1.27 | Philadelphia-chromosome-negative chronic myelogenous leukemia with incomplete trisomy 1q following chemotherapy for ovarian carcinoma. ( Haubenstock, A; Kabakow, B; Kim, HJ; Malamud, SC; Perle, MA; Vizel-Schwartz, M; Zalusky, R, 1985) |
| "Thirteen cases of acute nonlymphocytic leukemia occurred among 5455 patients, as compared to 0." | 1.26 | Acute leukemia after alkylating-agent therapy of ovarian cancer. ( Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (66.67) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weisdorf, D | 1 |
| Cooley, S | 1 |
| Devine, S | 1 |
| Fehniger, TA | 1 |
| DiPersio, J | 1 |
| Anasetti, C | 1 |
| Waller, EK | 1 |
| Porter, D | 1 |
| Farag, S | 1 |
| Drobyski, W | 1 |
| Defor, T | 1 |
| Haagenson, M | 1 |
| Curtsinger, J | 1 |
| Miller, J | 1 |
| PRAETORIUS, E | 1 |
| CHORIN, VA | 1 |
| ROSSOLIMO, OK | 1 |
| GOLDBERG, LE | 1 |
| STANISLAVSKAYA, MS | 1 |
| BLUMBERG, NA | 1 |
| VERTOGRADOVA, TP | 1 |
| GERICKE, D | 1 |
| RAVINA, A | 1 |
| BRIDGES, JB | 1 |
| BRIDGES, JM | 1 |
| EDELSTYN, GJ | 1 |
| LYONS, AR | 1 |
| Kröger, N | 1 |
| Damon, L | 1 |
| Zander, AR | 1 |
| Wandt, H | 1 |
| Derigs, G | 1 |
| Ferrante, P | 1 |
| Demirer, T | 1 |
| Rosti, G | 1 |
| Devetten, MP | 1 |
| Qazilbash, MH | 1 |
| Beall, CL | 1 |
| Bunner, P | 1 |
| Weisenborn, R | 1 |
| Lynch, JP | 1 |
| Ericson, SG | 1 |
| Appelbaum, FR | 1 |
| Raiola, AM | 1 |
| Van Lint, MT | 1 |
| Lamparelli, T | 1 |
| Gualandi, F | 1 |
| Mordini, N | 1 |
| Berisso, G | 1 |
| Bregante, S | 1 |
| Frassoni, F | 1 |
| Sessarego, M | 1 |
| Fugazza, G | 1 |
| Di Stefano, F | 1 |
| Pitto, A | 1 |
| Bacigalupo, A | 1 |
| Bergh, J | 1 |
| Wiklund, T | 1 |
| Erikstein, B | 1 |
| Lidbrink, E | 1 |
| Lindman, H | 1 |
| Malmström, P | 1 |
| Kellokumpu-Lehtinen, P | 1 |
| Bengtsson, NO | 1 |
| Söderlund, G | 1 |
| Anker, G | 1 |
| Wist, E | 1 |
| Ottosson, S | 1 |
| Salminen, E | 1 |
| Ljungman, P | 1 |
| Holte, H | 1 |
| Nilsson, J | 1 |
| Blomqvist, C | 1 |
| Wilking, N | 1 |
| Reimer, RR | 1 |
| Hoover, R | 1 |
| Fraumeni, JF | 1 |
| Young, RC | 1 |
| Meister, L | 1 |
| Close, P | 1 |
| Ruchelli, E | 1 |
| Silberberg, JM | 1 |
| Zarrabi, MH | 1 |
| Renner, D | 1 |
| Queisser, U | 1 |
| Martinez, C | 1 |
| Queisser, W | 1 |
| Haubenstock, A | 1 |
| Zalusky, R | 1 |
| Kim, HJ | 1 |
| Kabakow, B | 1 |
| Perle, MA | 1 |
| Malamud, SC | 1 |
| Vizel-Schwartz, M | 1 |
| Gerhartz, H | 1 |
| Staeuber, PG | 1 |
| Hampel, KE | 1 |
| Ruffner, BW | 1 |
| Sypkens Smit, CG | 1 |
| Meyler, L | 1 |
| Vortel, V | 1 |
| Peychl, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Profiling Neutrophil Counts in Patients With Cancer During Cycle One of Chemotherapy[NCT02806557] | 200 participants (Anticipated) | Observational | 2016-09-30 | Not yet recruiting | |||
| A Prospective Randomized Feasibility and Phase II Adjuvant Breast Cancer Study of the Netherlands Working Party for Autotransplantation in Solid Tumors.[NCT00851110] | Phase 2 | 50 participants (Anticipated) | Interventional | 2004-10-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thiotepa and Granulocytic Leukemia
| Article | Year |
|---|---|
Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients.
Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantat | 2003 |
Is there a best transplant conditioning regimen for acute myeloid leukemia?
Topics: Acute Disease; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantat | 2000 |
3 trials available for thiotepa and Granulocytic Leukemia
16 other studies available for thiotepa and Granulocytic Leukemia
| Article | Year |
|---|---|
[SURVIVAL TIME AND ABILITY TO WORK IN HEMOBLASTOSES TREATED BY CHEMOTHERAPY].
Topics: Antineoplastic Agents; Aziridines; Biomedical Research; Cyclophosphamide; Genetic Diseases, X-Linked | 1963 |
EXPERIMENTAL STUDY OF OLIVOMYCIN, AN ANTITUMOUR ANTIBIOTIC.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Busulfan; Carcin | 1964 |
[EXPERIENCE WITH ETHYLENEIMINES].
Topics: Animals; Antineoplastic Agents; Aziridines; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Leukemi | 1964 |
[THE PRACTITIONER AND ANTINEOPLASTIC CHEMOTHERAPY. RECENT DATA].
Topics: Antineoplastic Agents; Dactinomycin; Glioma; Hodgkin Disease; Leukemia; Leukemia, Myeloid; Perfusion | 1965 |
FEOTAL LIVER SUSPENSIONS IN THE TREATMENT OF MARROW APLASIA.
Topics: Anemia; Anemia, Aplastic; Antineoplastic Agents; Bone Marrow; Bone Marrow Diseases; Fetus; Hemoglobi | 1965 |
Reduced intensity thiotepa-cyclophosphamide conditioning for allogeneic haemopoietic stem cell transplants (HSCT) in patients up to 60 years of age.
Topics: Adult; Antineoplastic Agents, Alkylating; Cyclophosphamide; Drug Administration Schedule; Female; Fo | 2000 |
Acute leukemia after alkylating-agent therapy of ovarian cancer.
Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; | 1977 |
Granulocytic sarcoma or large cell lymphoma?
Topics: Biopsy; Child, Preschool; Cyclophosphamide; Daunorubicin; Diagnosis, Differential; Etoposide; Female | 1991 |
Acute nonlymphocytic leukemia after thiotepa instillation into the bladder: report of 2 cases and review of the literature.
Topics: Administration, Intravesical; Aged; Carcinoma, Papillary; Carcinoma, Transitional Cell; Humans; Leuk | 1987 |
Treatment of excessive thrombocythemia in chronic myeloid leukemia by thrombocytopheresis and intravenous Thio-TEPA.
Topics: Blood Component Removal; Bone Marrow; Humans; Leukemia, Myeloid; Male; Megakaryocytes; Middle Aged; | 1987 |
Philadelphia-chromosome-negative chronic myelogenous leukemia with incomplete trisomy 1q following chemotherapy for ovarian carcinoma.
Topics: Chromosomes, Human, 1-3; Female; Granulosa Cell Tumor; Humans; Leukemia, Myeloid; Middle Aged; Neopl | 1985 |
[On the treatment of hemoblastoses with N-diethyleneimidophosphonyl-N-phenylurea (C 73)].
Topics: Antineoplastic Agents; Aziridines; Azirines; Hematopoiesis; Hodgkin Disease; Humans; Leukemia, Lymph | 1965 |
[On the effect of cytostatic agents on human chromosomes].
Topics: Antineoplastic Agents; Chromosomes; Cytogenetics; Floxuridine; Humans; Hydrazines; Leukemia, Myeloid | 1968 |
Letter: Androgen role in erythroleukemia after treatment with alkylating agents.
Topics: Adult; Alkylating Agents; Androgens; Carcinoma, Intraductal, Noninfiltrating; Chlorambucil; Cytarabi | 1974 |
[A patient with ovarian cancer metastasis cured (?) by cytostatic agents and died from acute myeloid leukemia].
Topics: Adult; Cyclophosphamide; Cystadenoma; Female; Humans; Leukemia, Myeloid; Neoplasm Metastasis; Ovaria | 1970 |
[2 cases of acquired latent focal toxoplasmosis of the brain in a cytostatic and corticosteroid treated neoplastic disease].
Topics: Autopsy; Brain; Brain Diseases; Busulfan; Female; Focal Infection; Glycine; Humans; Leukemia, Myeloi | 1970 |