thiotepa and Glioma
thiotepa has been researched along with Glioma in 22 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine: (1) the maximum tolerable dose (MTD) of thiotepa (TT) that can be administered with etoposide without stem cell support; (2) whether this regimen is active against recurrent malignant gliomas." | 9.08 | Thiotepa and etoposide treatment of recurrent malignant gliomas: phase I study. ( Balmaceda, C; Fetell, MR; Hesdorffer, C, 1997) |
| "Twenty patients previously treated with surgery, radiation therapy and chemotherapy with a nitrosourea for malignant supratentorial gliomas received a combination of procarbazine, thiotepa and vincristine (P." | 9.07 | Treatment of recurrent malignant supratentorial gliomas with the association of procarbazine, thiotepa and vincristine: a phase II study. ( Ameri, A; Chen, QM; Delattre, JY; Poisson, M, 1993) |
| "Childhood malignant gliomas are rare, but their clinical behavior is almost as aggressive as in adults, with resistance to therapy, rapid progression, and not uncommonly, dissemination." | 6.71 | Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma. ( Bozzi, F; Casanova, M; Cefalo, G; Collini, P; Ferrari, A; Fossati-Bellani, F; Gandola, L; Giangaspero, F; Locatelli, F; Luksch, R; Massimino, M; Meazza, C; Pignoli, E; Podda, M; Polastri, D; Ravagnani, F; Riva, D; Scaramuzza, D; Solero, C; Spreafico, F; Terenziani, M; Zecca, M, 2005) |
| " Conventional phase II clinical trials conducted in patients with recurrent or progressive brainstem gliomas using single chemotherapy agents such as cyclophosphamide, carboplatin, cisplatin, etoposide and thiotepa or combinations of chemotherapy agents have produced low response rates in the range of 15-20%." | 5.08 | Contemporary chemotherapy issues for children with brainstem gliomas. ( Allen, JC; Siffert, J, 1996) |
| "To determine: (1) the maximum tolerable dose (MTD) of thiotepa (TT) that can be administered with etoposide without stem cell support; (2) whether this regimen is active against recurrent malignant gliomas." | 5.08 | Thiotepa and etoposide treatment of recurrent malignant gliomas: phase I study. ( Balmaceda, C; Fetell, MR; Hesdorffer, C, 1997) |
| "Twenty patients previously treated with surgery, radiation therapy and chemotherapy with a nitrosourea for malignant supratentorial gliomas received a combination of procarbazine, thiotepa and vincristine (P." | 5.07 | Treatment of recurrent malignant supratentorial gliomas with the association of procarbazine, thiotepa and vincristine: a phase II study. ( Ameri, A; Chen, QM; Delattre, JY; Poisson, M, 1993) |
| "By conventional Phase II criteria, thiotepa appears to have activity in medulloblastoma." | 5.07 | A phase II evaluation of thiotepa in pediatric central nervous system malignancies. ( Allen, JC; Balis, FM; Gillespie, A; Heideman, RL; Horowitz, ME; Kovnar, EH; Lange, B; Packer, RJ; Reaman, GH; Steinberg, SM, 1993) |
| "Nineteen patients with primary malignant gliomas were treated with thioTEPA." | 3.66 | Phase II evaluation of thioTEPA for treatment of central nervous system tumors. ( Edwards, MS; Levin, VA; Pischer, TL; Seager, ML; Wilson, CB, 1979) |
| "Childhood malignant gliomas are rare, but their clinical behavior is almost as aggressive as in adults, with resistance to therapy, rapid progression, and not uncommonly, dissemination." | 2.71 | Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma. ( Bozzi, F; Casanova, M; Cefalo, G; Collini, P; Ferrari, A; Fossati-Bellani, F; Gandola, L; Giangaspero, F; Locatelli, F; Luksch, R; Massimino, M; Meazza, C; Pignoli, E; Podda, M; Polastri, D; Ravagnani, F; Riva, D; Scaramuzza, D; Solero, C; Spreafico, F; Terenziani, M; Zecca, M, 2005) |
| "Four patients with primitive neuroectodermal tumors also had subdural fluid leaks, with meningeal enhancement over the effusion." | 1.35 | Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors. ( Adduci, A; Biassoni, V; Catania, S; Clerici, CA; Fossati-Bellani, F; Gandola, L; Luksch, R; Marchianò, A; Massimino, M; Meazza, C; Musumeci, R; Poggi, G; Simonetti, F; Spreafico, F; Terenziani, M, 2008) |
Research
Studies (22)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (36.36) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Lee, JW | 1 |
| Lim, DH | 1 |
| Sung, KW | 1 |
| Lee, HJ | 1 |
| Yi, ES | 1 |
| Yoo, KH | 1 |
| Koo, HH | 1 |
| Suh, YL | 1 |
| Shin, HJ | 1 |
| WINTER, A | 1 |
| RAVINA, A | 1 |
| SPENCER, RP | 1 |
| MARK, JB | 1 |
| FLANIGAN, S | 1 |
| Massimino, M | 2 |
| Gandola, L | 2 |
| Luksch, R | 2 |
| Spreafico, F | 2 |
| Riva, D | 1 |
| Solero, C | 1 |
| Giangaspero, F | 1 |
| Locatelli, F | 1 |
| Podda, M | 1 |
| Bozzi, F | 1 |
| Pignoli, E | 1 |
| Collini, P | 1 |
| Cefalo, G | 1 |
| Zecca, M | 1 |
| Casanova, M | 1 |
| Ferrari, A | 1 |
| Terenziani, M | 2 |
| Meazza, C | 2 |
| Polastri, D | 1 |
| Scaramuzza, D | 1 |
| Ravagnani, F | 1 |
| Fossati-Bellani, F | 2 |
| Thorarinsdottir, HK | 1 |
| Rood, B | 1 |
| Kamani, N | 1 |
| Lafond, D | 1 |
| Perez-Albuerne, E | 1 |
| Loechelt, B | 1 |
| Packer, RJ | 2 |
| MacDonald, TJ | 1 |
| Marchianò, A | 1 |
| Simonetti, F | 1 |
| Poggi, G | 1 |
| Adduci, A | 1 |
| Clerici, CA | 1 |
| Biassoni, V | 1 |
| Catania, S | 1 |
| Musumeci, R | 1 |
| Humeau, C | 1 |
| Vic, P | 1 |
| Arnal, F | 1 |
| Vlahovitch, B | 1 |
| Sentein, P | 1 |
| Ameri, A | 1 |
| Poisson, M | 1 |
| Chen, QM | 1 |
| Delattre, JY | 1 |
| Heideman, RL | 2 |
| Douglass, EC | 1 |
| Krance, RA | 1 |
| Fontanesi, J | 1 |
| Langston, JA | 1 |
| Sanford, RA | 1 |
| Kovnar, EH | 2 |
| Ochs, J | 1 |
| Kuttesch, J | 1 |
| Jenkins, JJ | 1 |
| Reaman, GH | 1 |
| Allen, JC | 2 |
| Lange, B | 1 |
| Horowitz, ME | 1 |
| Steinberg, SM | 1 |
| Gillespie, A | 1 |
| Balis, FM | 1 |
| Siffert, J | 1 |
| Bouffet, E | 2 |
| Mottolese, C | 1 |
| Jouvet, A | 1 |
| Philip, I | 1 |
| Frappaz, D | 1 |
| Carrie, C | 1 |
| Brunat-Mentigny, M | 1 |
| Balmaceda, C | 1 |
| Fetell, MR | 1 |
| Hesdorffer, C | 1 |
| Witham, TF | 1 |
| Fukui, MB | 1 |
| Meltzer, CC | 1 |
| Burns, R | 1 |
| Kondziolka, D | 1 |
| Bozik, ME | 1 |
| Raquin, M | 1 |
| Doz, F | 1 |
| Gentet, JC | 1 |
| Rodary, C | 1 |
| Demeocq, F | 1 |
| Chastagner, P | 1 |
| Lutz, P | 1 |
| Hartmann, O | 1 |
| Kalifa, C | 1 |
| Fisher, PG | 1 |
| Kadan-Lottick, NS | 1 |
| Korones, DN | 1 |
| Wilkinson, HA | 1 |
| Kornblith, P | 1 |
| Weems, S | 1 |
| Edwards, MS | 1 |
| Levin, VA | 1 |
| Seager, ML | 1 |
| Pischer, TL | 1 |
| Wilson, CB | 1 |
| Osinsky, SP | 1 |
| Evtushenko, GV | 1 |
| Annin, EA | 1 |
| Bubnovskaja, LN | 1 |
| Sato, O | 1 |
| Mahaley, MS | 1 |
| Woodhall, B | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase III Multicenter Study of Intratumoral/Interstitial Therapy With TransMID Compared to Best Standard of Care in Patients With Progressive and/or Recurrent, Non-Resectable Glioblastoma Multiforme[NCT00088400] | Phase 3 | 30 participants | Interventional | 2004-07-31 | Completed | ||
| Phase II, Single Arm, Open Label Clinical Trial With Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas[NCT01574092] | Phase 2 | 39 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
7 trials available for thiotepa and Glioma
| Article | Year |
|---|---|
Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols | 2005 |
Treatment of recurrent malignant supratentorial gliomas with the association of procarbazine, thiotepa and vincristine: a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Glioma; Humans; Male; Middle Ag | 1993 |
A phase II evaluation of thiotepa in pediatric central nervous system malignancies.
Topics: Adolescent; Adult; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Drug Administrati | 1993 |
Contemporary chemotherapy issues for children with brainstem gliomas.
Topics: Antineoplastic Agents; Brain Neoplasms; Brain Stem; Carboplatin; Carmustine; Dose-Response Relations | 1996 |
Etoposide and thiotepa followed by ABMT (autologous bone marrow transplantation) in children and young adults with high-grade gliomas.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brai | 1997 |
Thiotepa and etoposide treatment of recurrent malignant gliomas: phase I study.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Etoposide; | 1997 |
Survival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis.
Topics: Adult; Antineoplastic Agents, Alkylating; Arachnoid; Brain Neoplasms; Ependyma; Female; Glioma; Huma | 1999 |
Other Studies
15 other studies available for thiotepa and Glioma
| Article | Year |
|---|---|
Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for High-Grade Gliomas in Children and Adolescents.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child; Chi | 2017 |
Infusion chemotherapy for brain and neck cancer.
Topics: Brain; Brain Neoplasms; Glioma; Head and Neck Neoplasms; Humans; Methotrexate; Thiotepa | 1963 |
[THE PRACTITIONER AND ANTINEOPLASTIC CHEMOTHERAPY. RECENT DATA].
Topics: Antineoplastic Agents; Dactinomycin; Glioma; Hodgkin Disease; Leukemia; Leukemia, Myeloid; Perfusion | 1965 |
PERIPHERAL APPEARANCE OF RADIOLABELED ALBUMIN AND AN ALKYLATING AGENT DURING REGIONAL BRAIN PERFUSION.
Topics: Alkylating Agents; Blood; Brain; Brain Neoplasms; Cerebrovascular Circulation; Chemotherapy, Cancer, | 1964 |
Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child, Preschool; Cisp | 2007 |
Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols | 2008 |
[Effects of various antimitotics on cultured human glioma : demonstration of 2 types of simultaneous morphologic involvement, specific and nonspecific].
Topics: Antineoplastic Agents; Cell Cycle; Cells, Cultured; Glioma; Humans; Methotrexate; Microscopy, Electr | 1981 |
High-dose chemotherapy and autologous bone marrow rescue followed by interstitial and external-beam radiotherapy in newly diagnosed pediatric malignant gliomas.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brachythera | 1993 |
Radiotherapy followed by high dose busulfan and thiotepa: a prospective assessment of high dose chemotherapy in children with diffuse pontine gliomas.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Biops | 2000 |
Intrathecal thiotepa: reappraisal of an established therapy.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Cerebrospinal Fluid; Child; Child, Preschool; Cohort | 2002 |
Focal chemotherapy of brain tumours using semipermeable membranes.
Topics: Animals; Antineoplastic Agents; Bleomycin; Brain Neoplasms; Dactinomycin; Ependymoma; Fluorouracil; | 1977 |
Phase II evaluation of thioTEPA for treatment of central nervous system tumors.
Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Drug Evaluation; Glioblastoma; Glioma; Humans; Midd | 1979 |
Induced hyperglycemia and tumor chemotherapy: experimental and clinical studies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; | 1990 |
[Chemotherapy of malignant brain tumors by intermittent and continuous intra-arterial infusion of antitumor agents--clinical study].
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Arteries; Brain Edema; Brain Neoplasms; C | 1966 |
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carci | 1967 |