thiotepa has been researched along with Germinoma in 9 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Germinoma: A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paclitaxel is an antineoplastic agent that is used in the treatment of a variety of solid tumors." | 5.35 | Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma. ( Fangusaro, J; Finlay, J; Rook, J; Rosser, T, 2008) |
| " Since such treatment is relatively toxic, pharmacokinetic characteristics of total and ultrafiltered platinum, representing different species of platinum complexes formed, were investigated in 29 patients in relation to toxicity." | 2.70 | Toxicity of high-dose carboplatin: ultrafiltered and not total plasma pharmacokinetics is of clinical relevance. ( Beyer, J; Jaehde, U; Kloft, C; Siegert, W, 2002) |
| "Eleven patients with germ cell cancer relapsing from a complete remission and 7 patients with refractory germ cell cancer and/or an unresectable partial remission received salvage chemotherapy with one to two courses of carboplatin (800 mg/m2) and etoposide (500 mg/m2 on days 1, 3, and 5), followed by either one or two courses of carboplatin (1600 mg/m2), cyclophosphamide (6 g/m2), and thiotepa (480 mg/m2) divided over 4 days with autologous bone marrow transplantation and/or peripheral stem cell support." | 2.68 | Pilot study of a high-dose carboplatin-based salvage strategy for relapsing or refractory germ cell cancer. ( Richel, DJ; Rodenhuis, S; Schornagel, JH; ten Bokkel Huinink, WW; van der Wall, E; Vlasveld, LT, 1995) |
| "Paclitaxel is an antineoplastic agent that is used in the treatment of a variety of solid tumors." | 1.35 | Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma. ( Fangusaro, J; Finlay, J; Rook, J; Rosser, T, 2008) |
| " The toxic death rate was 1%." | 1.32 | Toxicity of the high-dose chemotherapy CTC regimen (cyclophosphamide, thiotepa, carboplatin): the Netherlands Cancer Institute experience. ( Baars, JW; Holtkamp, MJ; Rodenhuis, S; Schornagel, JH; Schrama, JG, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grodman, H | 1 |
| Wolfe, L | 1 |
| Kretschmar, C | 1 |
| Schrama, JG | 1 |
| Holtkamp, MJ | 1 |
| Baars, JW | 1 |
| Schornagel, JH | 2 |
| Rodenhuis, S | 2 |
| Tanji, S | 1 |
| Obara, W | 1 |
| Sugimura, J | 1 |
| Ohmori, S | 1 |
| Matsushita, Y | 1 |
| Tokunaga, H | 1 |
| Konda, R | 1 |
| Fujioka, T | 1 |
| Murai, K | 1 |
| Ishida, Y | 1 |
| Modak, S | 1 |
| Gardner, S | 1 |
| Dunkel, IJ | 1 |
| Balmaceda, C | 1 |
| Rosenblum, MK | 1 |
| Miller, DC | 1 |
| Halpern, S | 1 |
| Finlay, JL | 1 |
| Rook, J | 1 |
| Rosser, T | 1 |
| Fangusaro, J | 1 |
| Finlay, J | 1 |
| van der Wall, E | 1 |
| ten Bokkel Huinink, WW | 1 |
| Richel, DJ | 1 |
| Vlasveld, LT | 1 |
| Rick, O | 1 |
| Siegert, W | 2 |
| Beyer, J | 2 |
| De Giorgi, U | 1 |
| Rosti, G | 1 |
| Papiani, G | 1 |
| Marangolo, M | 1 |
| Kloft, C | 1 |
| Jaehde, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Randomized Feasibility and Phase II Adjuvant Breast Cancer Study of the Netherlands Working Party for Autotransplantation in Solid Tumors.[NCT00851110] | Phase 2 | 50 participants (Anticipated) | Interventional | 2004-10-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thiotepa and Germinoma
| Article | Year |
|---|---|
The status of high-dose chemotherapy with hematopoietic stem cell transplantation in germ cell tumor patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Cisplatin; Clinical T | 2002 |
2 trials available for thiotepa and Germinoma
| Article | Year |
|---|---|
Pilot study of a high-dose carboplatin-based salvage strategy for relapsing or refractory germ cell cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Com | 1995 |
Toxicity of high-dose carboplatin: ultrafiltered and not total plasma pharmacokinetics is of clinical relevance.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Combined M | 2002 |
6 other studies available for thiotepa and Germinoma
| Article | Year |
|---|---|
Outcome of patients with recurrent medulloblastoma or central nervous system germinoma treated with low dose continuous intravenous etoposide along with dose-intensive chemotherapy followed by autologous hematopoietic stem cell rescue.
Topics: Adolescent; Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nerv | 2009 |
Toxicity of the high-dose chemotherapy CTC regimen (cyclophosphamide, thiotepa, carboplatin): the Netherlands Cancer Institute experience.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Carboplatin; C | 2003 |
[Refractory germ cell cancer of testis treated by salvage high-dose chemotherapy: report of three cases].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Cisplatin | 2004 |
Thiotepa-based high-dose chemotherapy with autologous stem-cell rescue in patients with recurrent or progressive CNS germ cell tumors.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Child; Child, Preschool; Dise | 2004 |
Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain | 2008 |
High-dose salvage chemotherapy. Germ-cell tumor treatment results in Germany.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Clinical T | 1999 |