thiotepa has been researched along with Fibrosarcoma in 12 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| ") was administered just prior to an alkylating agent, the combination treatment produced significantly more tumor cell killing across the dosage range of each alkylating agent tested compared with the alkylating agent alone." | 5.28 | Modulation of alkylating agents by etanidazole and Fluosol-DA/carbogen in the FSaIIC fibrosarcoma and EMT6 mammary carcinoma. ( Bubley, G; Coleman, CN; Eder, JP; Frei, E; Herman, TS; Holden, SA; Tanaka, J; Teicher, BA, 1991) |
| "When melphalan was followed 3 or 7 days later by a second dose of melphalan there was evidence of resistance to the second dose of melphalan as indicated by subadditive tumor-cell killing." | 1.29 | A preclinical model for sequential high-dose chemotherapy. ( Ayash, LJ; Frei, E; Holden, SA; Teicher, BA, 1995) |
| ") was administered just prior to an alkylating agent, the combination treatment produced significantly more tumor cell killing across the dosage range of each alkylating agent tested compared with the alkylating agent alone." | 1.28 | Modulation of alkylating agents by etanidazole and Fluosol-DA/carbogen in the FSaIIC fibrosarcoma and EMT6 mammary carcinoma. ( Bubley, G; Coleman, CN; Eder, JP; Frei, E; Herman, TS; Holden, SA; Tanaka, J; Teicher, BA, 1991) |
| " In the FSaIIC murine fibrosarcoma tumor system, 5 intraperitoneal (IP) injections of 50 mg/kg of lonidamine over 36 hours increased the tumor cell kill by cisplatin, carboplatin, D-tetraplatin, melphalan and BCNU approximately two- to threefold over the dosage ranges of each drug tested when the antitumor agents were given IP immediately after the third lonidamine injection." | 1.28 | Modulation of alkylating agents by lonidamine in vivo. ( Frei, E; Herman, TS; Holden, SA; Teicher, BA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| VIGI, F | 1 |
| BIRINGER, A | 1 |
| HOLAN, J | 1 |
| MEDLA, F | 1 |
| Lisovskiĭ, MA | 1 |
| Komarov, VP | 1 |
| Petin, VG | 1 |
| Holden, SA | 3 |
| Teicher, BA | 3 |
| Ayash, LJ | 1 |
| Frei, E | 3 |
| Herman, TS | 2 |
| Tanaka, J | 1 |
| Eder, JP | 1 |
| Bubley, G | 1 |
| Coleman, CN | 1 |
| Krasovskiĭ, IM | 1 |
| Komurdzhiev, KhA | 1 |
| Il'inskaia, EG | 1 |
| Klimenkov, AA | 1 |
| Musatov, VK | 1 |
| Karapetian, RM | 1 |
| Yron, I | 1 |
| Weiss, DW | 1 |
| Robinson, E | 1 |
| Cohen, D | 1 |
| Adelberg, MG | 1 |
| Mekori, T | 1 |
| Haber, M | 1 |
| Barton, AA | 1 |
| Barton, M | 1 |
| Mahaley, MS | 1 |
| Woodhall, B | 1 |
| Musaev, KD | 1 |
12 other studies available for thiotepa and Fibrosarcoma
| Article | Year |
|---|---|
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambuci | 1963 |
OUR EXPERIENCES WITH CYTOSTATIC PERFUSIONS OF THE EXTREMITIES IN THE TREATMENT OF MALIGNANT TUMORS.
Topics: Animals; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Dogs; Drug Ther | 1964 |
[A mathematical description of the synergism in the simultaneous cytotoxic action of chemical agents and hyperthermia].
Topics: Animals; Cells, Cultured; Cisplatin; Cricetinae; Cricetulus; Drug Synergism; Female; Fibrosarcoma; H | 1994 |
A preclinical model for sequential high-dose chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclophosphamide; Doxorubicin; | 1995 |
Modulation of alkylating agents by etanidazole and Fluosol-DA/carbogen in the FSaIIC fibrosarcoma and EMT6 mammary carcinoma.
Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carbon Diox | 1991 |
Modulation of alkylating agents by lonidamine in vivo.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bone Marrow; Cell Survival; Cisplatin; Cyclophosp | 1991 |
[Intralymphatic infusion of chemotherapeutic preparations].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Female; Fibrosarcoma; Humans; Injections, Intralympha | 1968 |
[Treatment of disseminated sarcomas of the soft tissues].
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combinati | 1973 |
Immunotherapeutic studies in mice with the methanol-extraction residue (mer) fraction of BCG: solid tumors.
Topics: Animals; Antigens, Bacterial; BCG Vaccine; Benzopyrenes; Cyclophosphamide; Female; Fibrosarcoma; Flu | 1973 |
Electron microscope studies on the effect of thiotepa on the cytoplasm of fibrosarcoma cells grown in tissue culture.
Topics: Animals; Culture Techniques; Cytoplasm; Fibrosarcoma; Mice; Microscopy, Electron; Sarcoma, Experimen | 1965 |
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carci | 1967 |
[The results of treatment of maxillary sarcomas].
Topics: Adolescent; Adult; Aged; Child; Fibrosarcoma; Giant Cell Tumors; Hemangiosarcoma; Humans; Lymphoma, | 1970 |