thiotepa has been researched along with Ewing Sarcoma in 14 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Excerpt | Relevance | Reference |
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"We report a patient with renal insufficiency (creatinine clearance, CL(cr) = 38 mL/min) who received high-dose chemotherapy with cyclophosphamide (1,500 mg/m(2) day(-1)), thiotepa (120 mg/m(2) day(-1)) and carboplatin (AUC = 5 mg min/mL day(-1)) for four consecutive days." | 7.75 | Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency. ( Beijnen, JH; Ekhart, C; Huitema, AD; Kerst, JM; Rodenhuis, S, 2009) |
"We report a patient with renal insufficiency (creatinine clearance, CL(cr) = 38 mL/min) who received high-dose chemotherapy with cyclophosphamide (1,500 mg/m(2) day(-1)), thiotepa (120 mg/m(2) day(-1)) and carboplatin (AUC = 5 mg min/mL day(-1)) for four consecutive days." | 3.75 | Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency. ( Beijnen, JH; Ekhart, C; Huitema, AD; Kerst, JM; Rodenhuis, S, 2009) |
" Whenever one patient at one dosage level showed a grade III or grade IV reversible toxicity, additional patients were admitted (one by one) up to a maximum number of 6." | 2.69 | Phase I study of high-dose thiotepa with busulfan, etoposide, and autologous stem cell support in children with disseminated solid tumors. ( Bella, S; Burnelli, R; Garaventa, A; Locatelli, F; Melchionda, F; Paolucci, G; Pession, A; Prete, A, 1999) |
"ThioTEPA was administered intravenously every three weeks, at a dose of 65 mg/m2." | 2.68 | A phase II study of thioTEPA in children with recurrent solid tumor malignancies: a Children's Cancer Group study. ( Balis, FM; Bleyer, WA; Broxson, E; Geyer, JR; Heideman, R; Krailo, MD; Poplack, D; Sato, JK, 1996) |
"Melphalan was given i." | 2.68 | High-dose sequential chemotherapy and autologous stem cell reinfusion in advanced pediatric solid tumors. ( Ater, J; Chan, KW; Choroszy, M; Herzog, C; Jaffe, N; Korbling, M; Petropoulos, D, 1997) |
"Primary Ewing's sarcoma of the spine is reviewed, and seven cases are presented." | 2.38 | Treatment options in primary Ewing's sarcoma of the spine: report of seven cases and review of the literature. ( el-Khoury, GY; Haddad, FS; Haddad, SF; Hitchon, PW; Sharafuddin, MJ, 1992) |
" The conditioning regimen was well tolerated, without any toxic deaths." | 1.36 | Toxicity of high-dose chemotherapy with etoposide, thiotepa and CY in treating poor-prognosis Ewing's sarcoma family tumors: the experience of the Bambino Gesù Children's Hospital. ( Cozza, R; De Ioris, MA; De Lurentis, C; De Sio, L; Fidani, P; Ilari, I; Jenkner, A; Milano, GM; Pessolano, R, 2010) |
"All compounds reduced the growth of Ewing tumor cell lines in a dose-dependent manner." | 1.33 | In-vitro toxicity of Ukrain against human Ewing tumor cell lines. ( Boos, J; Köster, J; Lanvers-Kaminsky, C; Nolting, DM; Sandkötter, J; Schröder, A, 2006) |
"The principles of dose-response and combination chemotherapy were basic to the design of the initial curative standard-dose treatment regimens for leukemias, lymphomas, and testis cancer." | 1.28 | A phase I-II study of cyclophosphamide, thiotepa, and carboplatin with autologous bone marrow transplantation in solid tumor patients. ( Burke, J; Eder, JP; Elias, A; Frei, E; Hunt, M; Schnipper, LE; Schryber, SM; Shea, TC; Siegel, R; Teicher, BA, 1990) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (7.14) | 18.7374 |
1990's | 6 (42.86) | 18.2507 |
2000's | 4 (28.57) | 29.6817 |
2010's | 3 (21.43) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Loschi, S | 1 |
Dufour, C | 1 |
Oberlin, O | 1 |
Goma, G | 1 |
Valteau-Couanet, D | 1 |
Gaspar, N | 1 |
Jahnukainen, K | 1 |
Kallio, P | 1 |
Koivusalo, A | 1 |
Saarinen-Pihkala, UM | 1 |
Ilari, I | 1 |
De Ioris, MA | 1 |
Milano, GM | 1 |
Pessolano, R | 1 |
De Lurentis, C | 1 |
De Sio, L | 1 |
Fidani, P | 1 |
Jenkner, A | 1 |
Cozza, R | 1 |
Lanvers-Kaminsky, C | 1 |
Nolting, DM | 1 |
Köster, J | 1 |
Schröder, A | 1 |
Sandkötter, J | 1 |
Boos, J | 1 |
Ekhart, C | 1 |
Kerst, JM | 1 |
Rodenhuis, S | 1 |
Beijnen, JH | 1 |
Huitema, AD | 1 |
Geyer, JR | 1 |
Balis, FM | 1 |
Krailo, MD | 1 |
Heideman, R | 1 |
Broxson, E | 1 |
Sato, JK | 1 |
Poplack, D | 1 |
Bleyer, WA | 1 |
Chan, KW | 1 |
Petropoulos, D | 1 |
Choroszy, M | 1 |
Herzog, C | 1 |
Jaffe, N | 1 |
Ater, J | 1 |
Korbling, M | 1 |
Yonemoto, T | 1 |
Tatezaki, S | 1 |
Ishii, T | 1 |
Satoh, T | 1 |
Pession, A | 1 |
Prete, A | 1 |
Locatelli, F | 1 |
Bella, S | 1 |
Melchionda, F | 1 |
Garaventa, A | 1 |
Burnelli, R | 1 |
Paolucci, G | 1 |
Hawkins, D | 1 |
Barnett, T | 1 |
Bensinger, W | 1 |
Gooley, T | 1 |
Sanders, J | 1 |
Kushner, BH | 1 |
Meyers, PA | 1 |
Sharafuddin, MJ | 1 |
Haddad, FS | 1 |
Hitchon, PW | 1 |
Haddad, SF | 1 |
el-Khoury, GY | 1 |
Eder, JP | 1 |
Elias, A | 1 |
Shea, TC | 1 |
Schryber, SM | 1 |
Teicher, BA | 1 |
Hunt, M | 1 |
Burke, J | 1 |
Siegel, R | 1 |
Schnipper, LE | 1 |
Frei, E | 1 |
Clément, F | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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A Phase I Trial of Busulfan, Thiotepa and Melphalan Followed by Autologous or Syngeneic Peripheral Blood Stem Cell Transplantation and Followed by Total Marrow (Skeletal) Irradiation (TMI) in Patients With High-Risk Ewing's Sarcoma, PNET or Rhabdomyosarco[NCT00003081] | Phase 1 | 16 participants (Anticipated) | Interventional | 1998-03-31 | Completed | ||
Assessment of MGMT Promoter Methylation and Clinical Benefit From Temozolomide-based Therapy in Ewing Sarcoma Patients[NCT03542097] | 82 participants (Actual) | Observational | 2014-04-15 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 reviews available for thiotepa and Ewing Sarcoma
Article | Year |
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How effective is dose-intensive/myeloablative therapy against Ewing's sarcoma/primitive neuroectodermal tumor metastatic to bone or bone marrow? The Memorial Sloan-Kettering experience and a literature review.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Bone Neopl | 2001 |
Treatment options in primary Ewing's sarcoma of the spine: report of seven cases and review of the literature.
Topics: Adolescent; Adult; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cervical V | 1992 |
5 trials available for thiotepa and Ewing Sarcoma
Article | Year |
---|---|
Tandem high-dose chemotherapy strategy as first-line treatment of primary disseminated multifocal Ewing sarcomas in children, adolescents and young adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Child; Child, | 2015 |
A phase II study of thioTEPA in children with recurrent solid tumor malignancies: a Children's Cancer Group study.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Bone Neoplasms; Child; Humans; Neoplasms; Neuroectode | 1996 |
High-dose sequential chemotherapy and autologous stem cell reinfusion in advanced pediatric solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; | 1997 |
Phase I study of high-dose thiotepa with busulfan, etoposide, and autologous stem cell support in children with disseminated solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; C | 1999 |
Busulfan, melphalan, and thiotepa with or without total marrow irradiation with hematopoietic stem cell rescue for poor-risk Ewing-Sarcoma-Family tumors.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols | 2000 |
7 other studies available for thiotepa and Ewing Sarcoma
Article | Year |
---|---|
High-dose Thiotepa as Consolidation Therapy With Autologous Hematopoietic Stem Cell Transplantation for High-risk Ewing Family Tumors: Single-institution Experience.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone | 2015 |
Toxicity of high-dose chemotherapy with etoposide, thiotepa and CY in treating poor-prognosis Ewing's sarcoma family tumors: the experience of the Bambino Gesù Children's Hospital.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Chil | 2010 |
In-vitro toxicity of Ukrain against human Ewing tumor cell lines.
Topics: Berberine Alkaloids; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chelidonium; Dose-Response | 2006 |
Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclophosphamide; Drug Interacti | 2009 |
[High-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) for refractory bone and soft tissue sarcomas].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Busulfan; Child; | 1999 |
A phase I-II study of cyclophosphamide, thiotepa, and carboplatin with autologous bone marrow transplantation in solid tumor patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms | 1990 |
[The chemotherapy of cancer].
Topics: Adult; Alkylating Agents; Antimetabolites; Antineoplastic Agents; Dactinomycin; Female; Fluorouracil | 1967 |