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thiotepa and Ewing Sarcoma

thiotepa has been researched along with Ewing Sarcoma in 14 studies

Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

Research Excerpts

ExcerptRelevanceReference
"We report a patient with renal insufficiency (creatinine clearance, CL(cr) = 38 mL/min) who received high-dose chemotherapy with cyclophosphamide (1,500 mg/m(2) day(-1)), thiotepa (120 mg/m(2) day(-1)) and carboplatin (AUC = 5 mg min/mL day(-1)) for four consecutive days."7.75Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency. ( Beijnen, JH; Ekhart, C; Huitema, AD; Kerst, JM; Rodenhuis, S, 2009)
"We report a patient with renal insufficiency (creatinine clearance, CL(cr) = 38 mL/min) who received high-dose chemotherapy with cyclophosphamide (1,500 mg/m(2) day(-1)), thiotepa (120 mg/m(2) day(-1)) and carboplatin (AUC = 5 mg min/mL day(-1)) for four consecutive days."3.75Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency. ( Beijnen, JH; Ekhart, C; Huitema, AD; Kerst, JM; Rodenhuis, S, 2009)
" Whenever one patient at one dosage level showed a grade III or grade IV reversible toxicity, additional patients were admitted (one by one) up to a maximum number of 6."2.69Phase I study of high-dose thiotepa with busulfan, etoposide, and autologous stem cell support in children with disseminated solid tumors. ( Bella, S; Burnelli, R; Garaventa, A; Locatelli, F; Melchionda, F; Paolucci, G; Pession, A; Prete, A, 1999)
"ThioTEPA was administered intravenously every three weeks, at a dose of 65 mg/m2."2.68A phase II study of thioTEPA in children with recurrent solid tumor malignancies: a Children's Cancer Group study. ( Balis, FM; Bleyer, WA; Broxson, E; Geyer, JR; Heideman, R; Krailo, MD; Poplack, D; Sato, JK, 1996)
"Melphalan was given i."2.68High-dose sequential chemotherapy and autologous stem cell reinfusion in advanced pediatric solid tumors. ( Ater, J; Chan, KW; Choroszy, M; Herzog, C; Jaffe, N; Korbling, M; Petropoulos, D, 1997)
"Primary Ewing's sarcoma of the spine is reviewed, and seven cases are presented."2.38Treatment options in primary Ewing's sarcoma of the spine: report of seven cases and review of the literature. ( el-Khoury, GY; Haddad, FS; Haddad, SF; Hitchon, PW; Sharafuddin, MJ, 1992)
" The conditioning regimen was well tolerated, without any toxic deaths."1.36Toxicity of high-dose chemotherapy with etoposide, thiotepa and CY in treating poor-prognosis Ewing's sarcoma family tumors: the experience of the Bambino Gesù Children's Hospital. ( Cozza, R; De Ioris, MA; De Lurentis, C; De Sio, L; Fidani, P; Ilari, I; Jenkner, A; Milano, GM; Pessolano, R, 2010)
"All compounds reduced the growth of Ewing tumor cell lines in a dose-dependent manner."1.33In-vitro toxicity of Ukrain against human Ewing tumor cell lines. ( Boos, J; Köster, J; Lanvers-Kaminsky, C; Nolting, DM; Sandkötter, J; Schröder, A, 2006)
"The principles of dose-response and combination chemotherapy were basic to the design of the initial curative standard-dose treatment regimens for leukemias, lymphomas, and testis cancer."1.28A phase I-II study of cyclophosphamide, thiotepa, and carboplatin with autologous bone marrow transplantation in solid tumor patients. ( Burke, J; Eder, JP; Elias, A; Frei, E; Hunt, M; Schnipper, LE; Schryber, SM; Shea, TC; Siegel, R; Teicher, BA, 1990)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's6 (42.86)18.2507
2000's4 (28.57)29.6817
2010's3 (21.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Loschi, S1
Dufour, C1
Oberlin, O1
Goma, G1
Valteau-Couanet, D1
Gaspar, N1
Jahnukainen, K1
Kallio, P1
Koivusalo, A1
Saarinen-Pihkala, UM1
Ilari, I1
De Ioris, MA1
Milano, GM1
Pessolano, R1
De Lurentis, C1
De Sio, L1
Fidani, P1
Jenkner, A1
Cozza, R1
Lanvers-Kaminsky, C1
Nolting, DM1
Köster, J1
Schröder, A1
Sandkötter, J1
Boos, J1
Ekhart, C1
Kerst, JM1
Rodenhuis, S1
Beijnen, JH1
Huitema, AD1
Geyer, JR1
Balis, FM1
Krailo, MD1
Heideman, R1
Broxson, E1
Sato, JK1
Poplack, D1
Bleyer, WA1
Chan, KW1
Petropoulos, D1
Choroszy, M1
Herzog, C1
Jaffe, N1
Ater, J1
Korbling, M1
Yonemoto, T1
Tatezaki, S1
Ishii, T1
Satoh, T1
Pession, A1
Prete, A1
Locatelli, F1
Bella, S1
Melchionda, F1
Garaventa, A1
Burnelli, R1
Paolucci, G1
Hawkins, D1
Barnett, T1
Bensinger, W1
Gooley, T1
Sanders, J1
Kushner, BH1
Meyers, PA1
Sharafuddin, MJ1
Haddad, FS1
Hitchon, PW1
Haddad, SF1
el-Khoury, GY1
Eder, JP1
Elias, A1
Shea, TC1
Schryber, SM1
Teicher, BA1
Hunt, M1
Burke, J1
Siegel, R1
Schnipper, LE1
Frei, E1
Clément, F1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Trial of Busulfan, Thiotepa and Melphalan Followed by Autologous or Syngeneic Peripheral Blood Stem Cell Transplantation and Followed by Total Marrow (Skeletal) Irradiation (TMI) in Patients With High-Risk Ewing's Sarcoma, PNET or Rhabdomyosarco[NCT00003081]Phase 116 participants (Anticipated)Interventional1998-03-31Completed
Assessment of MGMT Promoter Methylation and Clinical Benefit From Temozolomide-based Therapy in Ewing Sarcoma Patients[NCT03542097]82 participants (Actual)Observational2014-04-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for thiotepa and Ewing Sarcoma

ArticleYear
How effective is dose-intensive/myeloablative therapy against Ewing's sarcoma/primitive neuroectodermal tumor metastatic to bone or bone marrow? The Memorial Sloan-Kettering experience and a literature review.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Feb-01, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Bone Neopl

2001
Treatment options in primary Ewing's sarcoma of the spine: report of seven cases and review of the literature.
    Neurosurgery, 1992, Volume: 30, Issue:4

    Topics: Adolescent; Adult; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cervical V

1992

Trials

5 trials available for thiotepa and Ewing Sarcoma

ArticleYear
Tandem high-dose chemotherapy strategy as first-line treatment of primary disseminated multifocal Ewing sarcomas in children, adolescents and young adults.
    Bone marrow transplantation, 2015, Volume: 50, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Child; Child,

2015
A phase II study of thioTEPA in children with recurrent solid tumor malignancies: a Children's Cancer Group study.
    Investigational new drugs, 1996, Volume: 13, Issue:4

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Bone Neoplasms; Child; Humans; Neoplasms; Neuroectode

1996
High-dose sequential chemotherapy and autologous stem cell reinfusion in advanced pediatric solid tumors.
    Bone marrow transplantation, 1997, Volume: 20, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool;

1997
Phase I study of high-dose thiotepa with busulfan, etoposide, and autologous stem cell support in children with disseminated solid tumors.
    Medical and pediatric oncology, 1999, Volume: 33, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; C

1999
Busulfan, melphalan, and thiotepa with or without total marrow irradiation with hematopoietic stem cell rescue for poor-risk Ewing-Sarcoma-Family tumors.
    Medical and pediatric oncology, 2000, Volume: 34, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols

2000

Other Studies

7 other studies available for thiotepa and Ewing Sarcoma

ArticleYear
High-dose Thiotepa as Consolidation Therapy With Autologous Hematopoietic Stem Cell Transplantation for High-risk Ewing Family Tumors: Single-institution Experience.
    Journal of pediatric hematology/oncology, 2015, Volume: 37, Issue:7

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone

2015
Toxicity of high-dose chemotherapy with etoposide, thiotepa and CY in treating poor-prognosis Ewing's sarcoma family tumors: the experience of the Bambino Gesù Children's Hospital.
    Bone marrow transplantation, 2010, Volume: 45, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Chil

2010
In-vitro toxicity of Ukrain against human Ewing tumor cell lines.
    Anti-cancer drugs, 2006, Volume: 17, Issue:9

    Topics: Berberine Alkaloids; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chelidonium; Dose-Response

2006
Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency.
    Cancer chemotherapy and pharmacology, 2009, Volume: 63, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclophosphamide; Drug Interacti

2009
[High-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) for refractory bone and soft tissue sarcomas].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Busulfan; Child;

1999
A phase I-II study of cyclophosphamide, thiotepa, and carboplatin with autologous bone marrow transplantation in solid tumor patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms

1990
[The chemotherapy of cancer].
    Praxis, 1967, Dec-07, Volume: 56, Issue:49

    Topics: Adult; Alkylating Agents; Antimetabolites; Antineoplastic Agents; Dactinomycin; Female; Fluorouracil

1967