thiotepa has been researched along with Ependymoma in 6 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "By conventional Phase II criteria, thiotepa appears to have activity in medulloblastoma." | 5.07 | A phase II evaluation of thiotepa in pediatric central nervous system malignancies. ( Allen, JC; Balis, FM; Gillespie, A; Heideman, RL; Horowitz, ME; Kovnar, EH; Lange, B; Packer, RJ; Reaman, GH; Steinberg, SM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thorarinsdottir, HK | 1 |
| Rood, B | 1 |
| Kamani, N | 1 |
| Lafond, D | 1 |
| Perez-Albuerne, E | 1 |
| Loechelt, B | 1 |
| Packer, RJ | 2 |
| MacDonald, TJ | 1 |
| Zacharoulis, S | 1 |
| Levy, A | 1 |
| Chi, SN | 1 |
| Gardner, S | 1 |
| Rosenblum, M | 1 |
| Miller, DC | 1 |
| Dunkel, I | 1 |
| Diez, B | 1 |
| Sposto, R | 1 |
| Ji, L | 1 |
| Asgharzadeh, S | 1 |
| Hukin, J | 1 |
| Belasco, J | 1 |
| Dubowy, R | 1 |
| Kellie, S | 1 |
| Termuhlen, A | 1 |
| Finlay, J | 1 |
| Heideman, RL | 1 |
| Reaman, GH | 1 |
| Allen, JC | 1 |
| Lange, B | 1 |
| Horowitz, ME | 1 |
| Steinberg, SM | 1 |
| Gillespie, A | 1 |
| Kovnar, EH | 1 |
| Balis, FM | 1 |
| Grill, J | 2 |
| Kalifa, C | 2 |
| Doz, F | 1 |
| Schoepfer, C | 1 |
| Sainte-Rose, C | 1 |
| Couanet, D | 1 |
| Terrier-Lacombe, MJ | 1 |
| Valteau-Couanet, D | 1 |
| Hartmann, O | 1 |
| Wilkinson, HA | 1 |
| Kornblith, P | 1 |
| Weems, S | 1 |
2 trials available for thiotepa and Ependymoma
| Article | Year |
|---|---|
A phase II evaluation of thiotepa in pediatric central nervous system malignancies.
Topics: Adolescent; Adult; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Drug Administrati | 1993 |
A high-dose busulfan-thiotepa combination followed by autologous bone marrow transplantation in childhood recurrent ependymoma. A phase-II study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brain Neopl | 1996 |
4 other studies available for thiotepa and Ependymoma
| Article | Year |
|---|---|
Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child, Preschool; Cisp | 2007 |
Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child; Child, Preschoo | 2007 |
High dose chemotherapy for childhood ependymona.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; | 1998 |
Focal chemotherapy of brain tumours using semipermeable membranes.
Topics: Animals; Antineoplastic Agents; Bleomycin; Brain Neoplasms; Dactinomycin; Ependymoma; Fluorouracil; | 1977 |