thiotepa has been researched along with Disease Models, Animal in 13 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ThioTEPA-treated mice subjected to an object recognition test 1, 2, 3, 4, 8, 12, 20 or 30 weeks following treatment demonstrated significant memory deficits at 12 and 20 weeks." | 5.36 | The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice. ( Gulinello, ME; Mondie, CM; Vandergrift, KA; Weber, ET; Wilson, CL, 2010) |
| " In conclusion, although TH produced only a moderate effect against BCL1 leukemia when used alone, its combination with CY is promising and should be tested further in allogeneic murine models and clinical studies." | 5.34 | The effect of high-dose thiotepa, alone or in combination with other chemotherapeutic agents, on a murine B-cell leukemia model simulating autologous stem cell transplantation. ( Abdul-Hai, A; Ergas, D; Resnick, IB; Shapira, MY; Slavin, S; Weiss, L, 2007) |
| "We investigated the effectiveness of intravesically administered drugs on the tumor incidence and tumor size in a FANFT-induced animal model for bladder cancer." | 3.66 | Single and sequential combination intravesical chemotherapy of murine bladder cancer. ( McCallum, LW; Murphy, WM; Nissenkorn, I; Soloway, MS, 1982) |
| "ThioTEPA-treated mice subjected to an object recognition test 1, 2, 3, 4, 8, 12, 20 or 30 weeks following treatment demonstrated significant memory deficits at 12 and 20 weeks." | 1.36 | The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice. ( Gulinello, ME; Mondie, CM; Vandergrift, KA; Weber, ET; Wilson, CL, 2010) |
| " In conclusion, although TH produced only a moderate effect against BCL1 leukemia when used alone, its combination with CY is promising and should be tested further in allogeneic murine models and clinical studies." | 1.34 | The effect of high-dose thiotepa, alone or in combination with other chemotherapeutic agents, on a murine B-cell leukemia model simulating autologous stem cell transplantation. ( Abdul-Hai, A; Ergas, D; Resnick, IB; Shapira, MY; Slavin, S; Weiss, L, 2007) |
| "thioTEPA was found to yield a pronounced dose-related inhibition in cell proliferation, while 5-fluorouracil did not." | 1.33 | Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA. ( Mignone, RG; Weber, ET, 2006) |
| "Chromosome aberrations were studied in cells of embryo liver of 101/H and CBA mice following mutagenic treatment with the alkylating agent--thiophosphamide." | 1.26 | [101/H line mice, a possible model of human chromosomal instability diseases]. ( Korogodina, IuV; S'iakste, TG, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Mondie, CM | 1 |
| Vandergrift, KA | 1 |
| Wilson, CL | 1 |
| Gulinello, ME | 1 |
| Weber, ET | 2 |
| Mignone, RG | 1 |
| Abdul-Hai, A | 1 |
| Weiss, L | 1 |
| Ergas, D | 1 |
| Resnick, IB | 1 |
| Slavin, S | 1 |
| Shapira, MY | 1 |
| Korogodina, IuV | 1 |
| S'iakste, TG | 1 |
| Soloway, MS | 2 |
| Nissenkorn, I | 1 |
| McCallum, LW | 1 |
| Murphy, WM | 1 |
| Teicher, BA | 1 |
| Ara, G | 1 |
| Keyes, SR | 1 |
| Herbst, RS | 1 |
| Frei, E | 1 |
| Martino, C | 1 |
| Chauffert, B | 1 |
| Dimanche-Boitrel, MT | 1 |
| Genne, P | 1 |
| Petit, JM | 1 |
| Onier, N | 1 |
| Jeannin, JF | 1 |
| Pan, JS | 1 |
| Slocum, HK | 1 |
| Rustum, YM | 1 |
| Greco, WR | 1 |
| Gaeta, JF | 1 |
| Huben, RP | 1 |
| Berenbaum, MC | 1 |
| Sheard, CE | 1 |
| Reittie, JR | 1 |
| Bundick, RV | 1 |
| Wilson, CB | 1 |
| Hoshino, T | 1 |
| Akinosho, EA | 1 |
| Basu, PK | 1 |
13 other studies available for thiotepa and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Bromodeoxyuridin | 2010 |
Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Ce | 2006 |
The effect of high-dose thiotepa, alone or in combination with other chemotherapeutic agents, on a murine B-cell leukemia model simulating autologous stem cell transplantation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cyclophosphamide; Disease Models, | 2007 |
[101/H line mice, a possible model of human chromosomal instability diseases].
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Disease Models, Animal; Female; Fetal Death; | 1981 |
Single and sequential combination intravesical chemotherapy of murine bladder cancer.
Topics: Animals; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Doxorubicin; Drug Therapy, Combin | 1982 |
Acute in vivo resistance in high-dose therapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cycloph | 1998 |
Prophylaxis of bladder tumor implantation. Intravesical and systemic chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Disease Models, Animal; Doxorubicin; F | 1976 |
[Experimental chemotherapy of peritoneal carcinomatosis of colonic origin in rats].
Topics: Animals; Antineoplastic Agents; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Disease Models, Anim | 1992 |
Inhibition of implantation of murine bladder tumor by thiotepa in cauterized bladder.
Topics: Administration, Intravesical; Animals; Carcinoma, Transitional Cell; Cautery; Disease Models, Animal | 1989 |
The growth of human tumours in immunosuppressed mice and their response to chemotherapy.
Topics: Animals; Chlorambucil; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Female; Fluorouracil; | 1974 |
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas.
Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis; | 1969 |
The control of corneal graft reaction by topical application of antimitotic agents (thio-tepa and colchicine).
Topics: Animals; Colchicine; Cornea; Corneal Transplantation; Disease Models, Animal; Graft Rejection; Histo | 1971 |