thiotepa has been researched along with Diffuse Mixed Small and Large Cell Lymphoma in 75 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this evaluation was to investigate the efficacy of high-dose chemotherapy with thiotepa, melphalan, and carboplatin (TMCb), and of autologous peripheral blood stem cell (PBSC) infusion in patients with aggressive non-Hodgkin's lymphoma (NHL) or Hodgkin's disease (HD)." | 7.72 | High-dose thiotepa, melphalan and carboplatin (TMCb) followed by autologous peripheral blood stem cell transplantation in patients with lymphoma -- a retrospective evaluation. ( Akan, H; Arat, M; Arslan, O; Ayli, M; Buyukberber, S; Demirer, T; Fen, T; Gurman, G; Ilhan, O; Ozcan, M, 2004) |
| "The purpose of this evaluation was to investigate the efficacy of high-dose chemotherapy with thiotepa, melphalan, and carboplatin (TMCb), and of autologous peripheral blood stem cell (PBSC) infusion in patients with aggressive non-Hodgkin's lymphoma (NHL) or Hodgkin's disease (HD)." | 3.72 | High-dose thiotepa, melphalan and carboplatin (TMCb) followed by autologous peripheral blood stem cell transplantation in patients with lymphoma -- a retrospective evaluation. ( Akan, H; Arat, M; Arslan, O; Ayli, M; Buyukberber, S; Demirer, T; Fen, T; Gurman, G; Ilhan, O; Ozcan, M, 2004) |
| "Nineteen patients with metastatic breast cancer and six patients with refractory non-Hodgkin's lymphoma were initially treated with etoposide (VP-16) (2 gm/m2) and granulocyte-colony stimulating factor (G-CSF)." | 3.69 | Multiple cycles of high dose chemotherapy supported by hematopoietic progenitor cells as treatment for patients with advanced malignancies. ( Blume, KG; Chao, NJ; Hoyle, CF; Kusnierz-Glaz, CR; Long, GD; Negrin, RS; Schriber, JR, 1995) |
| "Lymphopenia was also a significant prognostic factor for progression-free survival (HR 3." | 1.43 | A new prognostic model using absolute lymphocyte count in patients with primary central nervous system lymphoma. ( Cheong, JW; Cho, H; Chung, H; Jang, JE; Kim, JS; Kim, SJ; Kim, Y; Kim, YR; Lee, JY; Min, YH; Park, H, 2016) |
| " TMJ is a safe and effective regimen when used as a part of autologous stem cell transplant for patients with HD and NHL." | 1.32 | High dose chemotherapy with thiotepa, mitoxantrone and carboplatin (TMJ) followed by autologous stem cell support in 100 consecutive lymphoma patients in a single centre: analysis of efficacy, toxicity and prognostic factors. ( Ahmed, T; Hoang, A; Kancherla, R; Liu, D; Qureshi, Z; Seiter, K; Waheed, F, 2004) |
| " The BAD pump was safe and effective in minimizing nausea and vomiting associated with HDC, and thus, eliminated the need for hospitalization for management of chemotherapy-induced nausea and vomiting." | 1.30 | Safety and efficacy of a continuous infusion, patient controlled anti-emetic pump to facilitate outpatient administration of high-dose chemotherapy. ( Belt, R; Coon, J; Cord, M; Dix, S; Geller, R; Howard, S, 1999) |
| "Hydroxyurea is an antineoplastic drug with a broad spectrum of clinical activity and minimal nonhematopoietic toxicity." | 1.28 | High-dose hydroxyurea in autologous bone marrow transplantation: a promising "new" agent. ( Armitage, JO; Bierman, PJ; Glenn, LD; Kessinger, A; Reed, EC; Vaughan, WP, 1992) |
| "Forty patients with refractory solid tumors or non-Hodgkin's lymphoma were treated with high-dose cyclophosphamide, thiotepa, and carmustine (BCNU), followed by autologous stem cell rescue, in a phase I dose escalation study." | 1.28 | High-dose tri-alkylator chemotherapy with autologous stem cell rescue in patients with refractory malignancies. ( Bitran, JD; Garner, M; Kaminer, LS; Moormeier, JA; Williams, SF, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (38.67) | 18.7374 |
| 1990's | 15 (20.00) | 18.2507 |
| 2000's | 10 (13.33) | 29.6817 |
| 2010's | 14 (18.67) | 24.3611 |
| 2020's | 7 (9.33) | 2.80 |
| Authors | Studies |
|---|---|
| Fox, CP | 1 |
| Ali, AS | 1 |
| McIlroy, G | 1 |
| Thust, S | 1 |
| Martinez-Calle, N | 1 |
| Jackson, AE | 1 |
| Hopkins, LM | 1 |
| Thomas, CM | 1 |
| Kassam, S | 1 |
| Wright, J | 1 |
| Chaganti, S | 1 |
| Smith, J | 1 |
| Chau, I | 1 |
| Culligan, D | 1 |
| Linton, KM | 1 |
| Collins, GP | 1 |
| Ferreri, AJM | 1 |
| Lewis, D | 1 |
| Davies, AJ | 1 |
| Johnson, R | 1 |
| Auer, DP | 1 |
| Cwynarski, K | 1 |
| Sumangala, S | 1 |
| Htwe, T | 1 |
| Ansari, Y | 1 |
| Martinez-Alvarez, L | 1 |
| Nagane, M | 1 |
| Kaulen, LD | 1 |
| Baehring, JM | 1 |
| Kodama, Y | 1 |
| Saburi, M | 1 |
| Maruyama, R | 1 |
| Sakata, M | 1 |
| Takata, H | 1 |
| Miyazaki, Y | 1 |
| Kawano, K | 1 |
| Wada, J | 1 |
| Urabe, S | 1 |
| Hazuku, T | 1 |
| Ohtsuka, E | 1 |
| Cohen, YI | 1 |
| Lebel, E | 1 |
| Zimran, E | 1 |
| Shaulov, A | 1 |
| Stepensky, P | 1 |
| Grisariu, S | 1 |
| Avni, B | 1 |
| Scordo, M | 1 |
| Wang, TP | 1 |
| Ahn, KW | 1 |
| Chen, Y | 1 |
| Ahmed, S | 1 |
| Awan, FT | 1 |
| Beitinjaneh, A | 1 |
| Chen, A | 1 |
| Chow, VA | 1 |
| Dholaria, B | 1 |
| Epperla, N | 1 |
| Farooq, U | 1 |
| Ghosh, N | 1 |
| Grover, N | 1 |
| Hamad, N | 1 |
| Hildebrandt, GC | 1 |
| Holmberg, L | 3 |
| Hong, S | 1 |
| Inwards, DJ | 1 |
| Jimenez-Jimenez, A | 1 |
| Karmali, R | 1 |
| Kenkre, VP | 1 |
| Khimani, F | 1 |
| Klyuchnikov, E | 1 |
| Krem, MM | 1 |
| Munshi, PN | 1 |
| Nieto, Y | 1 |
| Prestidge, T | 1 |
| Ramakrishnan Geethakumari, P | 1 |
| Rezvani, AR | 1 |
| Riedell, PA | 1 |
| Seo, S | 1 |
| Shah, NN | 1 |
| Solh, M | 1 |
| Yared, JA | 1 |
| Kharfan-Dabaja, MA | 1 |
| Herrera, A | 1 |
| Hamadani, M | 2 |
| Sauter, CS | 2 |
| Qualls, D | 1 |
| Sullivan, A | 1 |
| Li, S | 2 |
| Brunner, AM | 1 |
| Collier, K | 1 |
| Hochberg, E | 2 |
| Armand, P | 3 |
| Batchelor, TT | 2 |
| Chen, YB | 3 |
| DeFilipp, Z | 1 |
| Kondo, E | 1 |
| Ikeda, T | 1 |
| Izutsu, K | 1 |
| Chihara, D | 1 |
| Shimizu-Koresawa, R | 1 |
| Fujii, N | 1 |
| Sakai, T | 1 |
| Kondo, T | 1 |
| Kubo, K | 1 |
| Kato, Y | 1 |
| Akasaka, T | 1 |
| Fukuda, T | 1 |
| Ichinohe, T | 1 |
| Atsuta, Y | 1 |
| Suzumiya, J | 1 |
| Suzuki, R | 1 |
| Hu, B | 1 |
| Hatakeyama, N | 1 |
| Hori, T | 1 |
| Yamamoto, M | 1 |
| Mizue, N | 1 |
| Igarashi, K | 1 |
| Suzuki, N | 1 |
| Tsutsumi, H | 1 |
| Batchelor, T | 1 |
| Brezina, M | 1 |
| Jones, S | 1 |
| Del Rio, C | 1 |
| Curtis, M | 1 |
| Ballen, KK | 1 |
| Barnes, J | 1 |
| Chi, AS | 1 |
| Dietrich, J | 1 |
| Driscoll, J | 1 |
| Gertsner, ER | 1 |
| Hochberg, F | 1 |
| LaCasce, AS | 2 |
| McAfee, SL | 2 |
| Spitzer, TR | 1 |
| Nayak, L | 1 |
| Bojic, M | 1 |
| Berghoff, AS | 1 |
| Troch, M | 1 |
| Agis, H | 1 |
| Sperr, WR | 1 |
| Widhalm, G | 1 |
| Wöhrer, A | 1 |
| Kalhs, P | 1 |
| Preusser, M | 1 |
| Rabitsch, W | 1 |
| Omuro, A | 1 |
| Correa, DD | 1 |
| DeAngelis, LM | 2 |
| Moskowitz, CH | 1 |
| Matasar, MJ | 1 |
| Kaley, TJ | 1 |
| Gavrilovic, IT | 1 |
| Nolan, C | 1 |
| Pentsova, E | 1 |
| Grommes, CC | 1 |
| Panageas, KS | 1 |
| Baser, RE | 1 |
| Faivre, G | 1 |
| Abrey, LE | 2 |
| Jang, JE | 1 |
| Kim, YR | 1 |
| Kim, SJ | 2 |
| Cho, H | 1 |
| Chung, H | 1 |
| Lee, JY | 1 |
| Park, H | 1 |
| Kim, Y | 1 |
| Cheong, JW | 1 |
| Min, YH | 1 |
| Kim, JS | 1 |
| Schorb, E | 2 |
| Finke, J | 2 |
| Ferreri, AJ | 2 |
| Ihorst, G | 2 |
| Mikesch, K | 1 |
| Kasenda, B | 2 |
| Fritsch, K | 2 |
| Fricker, H | 2 |
| Burger, E | 1 |
| Grishina, O | 1 |
| Valk, E | 2 |
| Zucca, E | 1 |
| Illerhaus, G | 2 |
| Egerer, G | 1 |
| Lamprecht, M | 1 |
| Keller, U | 1 |
| Wolf, HH | 1 |
| Hirt, C | 1 |
| Stilgenbauer, S | 1 |
| Binder, M | 1 |
| Hau, P | 1 |
| Edinger, M | 1 |
| Frickhofen, N | 1 |
| Bentz, M | 1 |
| Möhle, R | 1 |
| Röth, A | 1 |
| Pfreundschuh, M | 1 |
| von Baumgarten, L | 1 |
| Deckert, M | 1 |
| Hader, C | 1 |
| Shah, N | 1 |
| Rauenzahn, S | 1 |
| Veltri, L | 1 |
| Wen, S | 1 |
| Craig, M | 1 |
| Kanate, AS | 1 |
| Cumpston, A | 1 |
| Zaucha, R | 1 |
| Gooley, T | 2 |
| Gopal, AK | 1 |
| Press, O | 2 |
| Maloney, D | 1 |
| Bensinger, WI | 2 |
| Lee, SC | 1 |
| Lee, DH | 1 |
| Kim, WS | 1 |
| Suh, C | 1 |
| Won, JH | 1 |
| Cote, GM | 1 |
| Hochberg, EP | 1 |
| Muzikansky, A | 1 |
| Hochberg, FH | 1 |
| Drappatz, J | 1 |
| Fisher, DC | 1 |
| Abramson, JS | 1 |
| Falzetti, F | 1 |
| Di Ianni, M | 1 |
| Ballanti, S | 1 |
| Iodice, G | 1 |
| Reale, A | 1 |
| Minelli, O | 1 |
| Serio, G | 1 |
| Martelli, MF | 1 |
| Dammacco, F | 1 |
| Vacca, A | 1 |
| Ria, R | 1 |
| ISRAELS, MC | 2 |
| LEONARD, BJ | 2 |
| WILKINSON, JF | 2 |
| IAKUBCHIK, FM | 1 |
| ROSSOLIMO, OK | 3 |
| LEPESHKINA, GN | 2 |
| BRINDLEY, CO | 1 |
| ZEZZANETO, L | 1 |
| SOERENSEN, B | 1 |
| SALIBA, AM | 1 |
| GRECCHI, R | 1 |
| VIGI, F | 1 |
| PRAETORIUS, E | 1 |
| ARIEL, IM | 1 |
| RESNICK, MI | 1 |
| GALEY, D | 1 |
| SLOBODA, AE | 1 |
| VOGEL, AW | 1 |
| PRADHAN, SN | 1 |
| WEST, WL | 1 |
| HILLER, SA | 1 |
| LIDAKS, MJ | 1 |
| ZIDERMANE, AA | 1 |
| GERMANE, SK | 1 |
| GRIGALINOVICH, GA | 1 |
| DAUVARTS, AZ | 1 |
| KRAVCHENKO, IM | 1 |
| PRESS, BO | 1 |
| CHORIN, VA | 1 |
| GOLDBERG, LE | 1 |
| STANISLAVSKAYA, MS | 1 |
| BLUMBERG, NA | 1 |
| VERTOGRADOVA, TP | 1 |
| BOURDIN, JS | 1 |
| SARACINO, RT | 1 |
| LILLE, I | 1 |
| GABAY, F | 1 |
| COSTAKEL, O | 1 |
| KADYROV, FA | 1 |
| GERICKE, D | 1 |
| ROSENGERG, LM | 1 |
| POLANCO, GB | 1 |
| BLANK, S | 1 |
| McCoy, AG | 1 |
| Smith, EP | 1 |
| Atkinson, ME | 1 |
| Baranski, B | 1 |
| Kahl, BS | 1 |
| Juckett, M | 1 |
| Mitchell, T | 1 |
| Gangnon, R | 1 |
| Longo, WL | 1 |
| Lai, R | 1 |
| Rosenblum, MK | 1 |
| Demirer, T | 1 |
| Ayli, M | 1 |
| Fen, T | 1 |
| Ozcan, M | 1 |
| Arat, M | 1 |
| Buyukberber, S | 1 |
| Arslan, O | 1 |
| Gurman, G | 1 |
| Akan, H | 1 |
| Ilhan, O | 1 |
| Shim, BY | 1 |
| Lee, MA | 1 |
| Byun, JH | 1 |
| Roh, SY | 1 |
| Song, CW | 1 |
| Park, JN | 1 |
| Lee, JW | 1 |
| Min, WS | 1 |
| Hong, YS | 1 |
| Kim, CC | 1 |
| Waheed, F | 1 |
| Kancherla, R | 1 |
| Seiter, K | 1 |
| Liu, D | 1 |
| Qureshi, Z | 1 |
| Hoang, A | 1 |
| Ahmed, T | 1 |
| Dell'Oro, S | 1 |
| Foppoli, M | 1 |
| Bernardi, M | 1 |
| Brandes, AA | 1 |
| Tosoni, A | 1 |
| Montanari, M | 1 |
| Balzarotti, M | 1 |
| Spina, M | 1 |
| Ilariucci, F | 1 |
| Zaja, F | 1 |
| Stelitano, C | 1 |
| Bobbio, F | 1 |
| Corazzelli, G | 1 |
| Baldini, L | 1 |
| Ponzoni, M | 1 |
| Picozzi, P | 1 |
| Caligaris Cappio, F | 1 |
| Reni, M | 1 |
| Xu, T | 1 |
| van Besien, KW | 1 |
| Khouri, IF | 1 |
| Giralt, SA | 1 |
| McCarthy, P | 1 |
| Mehra, R | 2 |
| Andersson, BS | 1 |
| Przepiorka, D | 2 |
| Gajewski, JL | 1 |
| Bellare, N | 1 |
| Nath, R | 1 |
| Long, GD | 1 |
| Negrin, RS | 1 |
| Hoyle, CF | 1 |
| Kusnierz-Glaz, CR | 1 |
| Schriber, JR | 1 |
| Blume, KG | 1 |
| Chao, NJ | 1 |
| Stahel, RA | 1 |
| Jost, LM | 1 |
| Honegger, H | 1 |
| Betts, E | 1 |
| Goebel, ME | 1 |
| Nagler, A | 1 |
| Fontelonga, A | 1 |
| Kelly, AJ | 1 |
| MacKintosh, FR | 1 |
| Hall, S | 1 |
| Monroe, P | 1 |
| Wilson, GS | 1 |
| Shaft, D | 1 |
| Ruthven, A | 1 |
| Ascensao, JL | 1 |
| van Besien, K | 1 |
| Thall, P | 1 |
| Korbling, M | 1 |
| Pugh, WC | 1 |
| Khouri, I | 1 |
| Giralt, S | 1 |
| Anderlini, P | 1 |
| Amin, K | 1 |
| Mirza, N | 1 |
| Seong, D | 1 |
| Gajewski, J | 1 |
| Hester, J | 1 |
| Andersson, B | 1 |
| Cabanillas, F | 1 |
| Champlin, R | 1 |
| Chamberlain, MC | 1 |
| Kormanik, PA | 1 |
| Schiffman, K | 1 |
| Buckner, CD | 1 |
| Maziarz, R | 1 |
| Maloney, DG | 1 |
| Appelbaum, FR | 1 |
| Lilleby, K | 1 |
| Clift, R | 1 |
| Zuckerman, N | 1 |
| Klarnet, J | 1 |
| Weaver, C | 1 |
| Chauncey, T | 1 |
| Kanteti, R | 1 |
| Miller, K | 1 |
| McCann, J | 1 |
| Roitman, D | 1 |
| Morelli, J | 1 |
| Hurley, C | 1 |
| Berkman, E | 1 |
| Schenkein, D | 1 |
| Dix, S | 1 |
| Cord, M | 1 |
| Howard, S | 1 |
| Coon, J | 1 |
| Belt, R | 1 |
| Geller, R | 1 |
| Sica, S | 1 |
| Cicconi, S | 1 |
| Sorà, F | 1 |
| Chiusolo, P | 1 |
| Piccirillo, N | 1 |
| Laurenti, L | 1 |
| La Barbera, EO | 1 |
| Giordano, G | 1 |
| Leone, G | 1 |
| Soussain, C | 1 |
| Suzan, F | 1 |
| Hoang-Xuan, K | 1 |
| Cassoux, N | 1 |
| Levy, V | 1 |
| Azar, N | 1 |
| Belanger, C | 1 |
| Achour, E | 1 |
| Ribrag, V | 1 |
| Gerber, S | 1 |
| Delattre, JY | 1 |
| Leblond, V | 1 |
| Lichtman, SM | 1 |
| Kolitz, J | 1 |
| Budman, DR | 1 |
| Schulman, P | 1 |
| Vinciguerra, V | 1 |
| Hoffman, M | 1 |
| Mittelman, A | 1 |
| Allen, SL | 1 |
| Fusco, D | 1 |
| Hayes, FA | 1 |
| Fisher, PG | 1 |
| Kadan-Lottick, NS | 1 |
| Korones, DN | 1 |
| Iaremenko, KV | 1 |
| Eremeeva, AA | 1 |
| Tereshin, IM | 1 |
| Mukaiyama, T | 2 |
| Ogawa, M | 2 |
| Horikoshi, N | 2 |
| Inoue, K | 2 |
| Aiba, K | 1 |
| Matsuoka, A | 2 |
| Matsumura, T | 2 |
| Ogihara, A | 1 |
| Sumida, T | 1 |
| Vaughan, WP | 1 |
| Bierman, PJ | 1 |
| Reed, EC | 1 |
| Glenn, LD | 1 |
| Kessinger, A | 1 |
| Armitage, JO | 1 |
| Moormeier, JA | 1 |
| Williams, SF | 1 |
| Kaminer, LS | 1 |
| Garner, M | 1 |
| Bitran, JD | 1 |
| Hirano, A | 1 |
| Mizunuma, N | 1 |
| Gary-Bobo, J | 1 |
| Potopal'skiĭ, AI | 1 |
| Shishka, GV | 1 |
| Iordan, AM | 1 |
| Pol'kina, RI | 2 |
| Kholodnyi, MD | 1 |
| Mindlin, SS | 1 |
| Nelson, RS | 1 |
| Lanza, FL | 1 |
| Musaev, KD | 1 |
| Maliugina, LL | 1 |
| Remizov, AL | 1 |
| Petrov, AS | 1 |
| Kraĭz, BO | 1 |
| Lazarev, NV | 1 |
| Miuller, NR | 1 |
| Mashburn, LT | 1 |
| Stengrevits, AA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Hihg-Dose Thiotepa, Busulfan, Cyclophosphamide, and Rituximab With Autologous Stem Cell Transplantation for Patients With CNS Involvement by Non-Hodgkin's Lymphoma or Primary CNS Lymphoma[NCT01182415] | Phase 2 | 30 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| A Phase II， Single-arm Trail of Chidamide Combined With Rituximab and High-dose Methotrexate in Previously Untreated Patients With Primary Central Nervous System Lymphoma[NCT04516655] | Phase 2 | 51 participants (Anticipated) | Interventional | 2020-09-01 | Not yet recruiting | ||
| Rituximab, Methotrexate, Procarbazine and Vincristine Followed by High-dose Chemotherapy With Autologous Stem-cell Rescue in Newly-diagnosed Primary CNS Lymphoma (PCNSL)[NCT00596154] | Phase 2 | 33 participants (Actual) | Interventional | 2004-12-31 | Completed | ||
| High-dose Chemotherapy and Autologous Stem Cell Transplant or Consolidating Conventional Chemotherapy in Primary CNS Lymphoma - Randomized Phase III Trial[NCT02531841] | Phase 3 | 250 participants (Anticipated) | Interventional | 2014-07-31 | Recruiting | ||
| Freiburg ZNS-NHL Study: Therapy for Patients With Primary Non-Hodgkin Lymphoma of the CNS - Sequential High Dosage Chemotherapy With Autologous Peripheral Blood Stem Cell Plantation[NCT00647049] | Phase 2 | 78 participants (Anticipated) | Interventional | 2007-01-31 | Recruiting | ||
| A Phase 2a Study of the Addition of Temozolomide to a Standard Conditioning Regimen for Autologous Stem Cell Transplantation in Relapsed and Refractory Central Nervous System (CNS) Lymphoma[NCT01235793] | Phase 2 | 11 participants (Actual) | Interventional | 2010-10-14 | Terminated (stopped due to The clinical trial was terminated due to poor enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The percentage of participants alive after two years (NCT01182415)
Timeframe: 2 years
| Intervention | percentage of participants (Number) |
|---|---|
| High-dose Chemotherapy With Autologous Stem Cell Transplant | 93 |
The percentage of participants alive and without disease progression at 2 years. Disease progression was judged through clinical impression and MRI imaging. (NCT01182415)
Timeframe: 2 years
| Intervention | percentage of participants (Number) |
|---|---|
| High-dose Chemotherapy With Autologous Stem Cell Transplant | 81 |
The proportion of patients with central nervous system (CNS) involvement by B-cell Non-Hodgkin's Lymphoma (NHL), relapsed primary central nervous system lymphoma (PCNSL), or relapsed primary intraocular lymphoma (PIOL) who are alive and progression-free at one year. Relapse was defined as per standard PCNSL criteria from clinical and MRI criteria. (NCT01182415)
Timeframe: 3 years
| Intervention | Participants (Count of Participants) |
|---|---|
| High-dose Chemotherapy With Autologous Stem Cell Transplant | 28 |
The number of participants that achieved complete remission following high dose chemotherapy and autologous stem cell transplantation (ASCT). Complete remission is defined as the disappearance of all evidence of disease. Response was judged by MRI assessment. (NCT01182415)
Timeframe: 3 years
| Intervention | Participants (Count of Participants) |
|---|---|
| High-dose Chemotherapy With Autologous Stem Cell Transplant | 29 |
Safety will be assessed using a dose escalation design for temozolomide's use to determine the target dose and also to evaluate any and all acute treatment related toxicities. During the course of patient follow up and therapy, toxicities will be evaluated, particularly as the investigators will be determining the target dose of temozolomide. One of the major criteria for dose limiting toxicity for the study will be any Grade 3 or 4 nonhematologic toxicity from a list of commonly expected toxicities associated with autologous transplantation and temozolomide. (NCT01235793)
Timeframe: One Year
| Intervention | dose in mg/m^2 (Number) |
|---|---|
| DRBEAT Regimen | 773.25 |
"Efficacy of the DRBEAT Regimen will be assessed by analysis of~one-year progression-free survival (PFS), defined as the time interval from maximal response from therapy to tumor regrowth, progression*, or death, (*Progression is defined as meeting the response criteria listed in Table 4: Response Criteria for Primary Central Nervous System Lymphoma according to Abrey LE, Batchelor TT, Ferreri AJM et al.)~and~Overall survival, defined as the time interval between the date of transplant and the date of death from any cause." (NCT01235793)
Timeframe: (1) One Year (2) Until date of death from any cause, assessed up to 2 years
| Intervention | Days (Median) | |
|---|---|---|
| Progression Free Survival | Overall Survival | |
| DRBEAT Regimen | 132 | 564 |
3 reviews available for thiotepa and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
Treatment Options for Recurrent Primary CNS Lymphoma.
Topics: Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms | 2022 |
Haematopoietic stem cell transplantation for treatment of primary CNS lymphoma: single-centre experience and literature review.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; | 2015 |
Treatment-induced leukoencephalopathy in primary CNS lymphoma: a clinical and autopsy study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Cranial Irradia | 2004 |
16 trials available for thiotepa and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
A phase 1/2 study of thiotepa-based immunochemotherapy in relapsed/refractory primary CNS lymphoma: the TIER trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hematopoietic Stem Cell T | 2021 |
Phase 2 trial of high-dose rituximab with high-dose cytarabine mobilization therapy and high-dose thiotepa, busulfan, and cyclophosphamide autologous stem cell transplantation in patients with central nervous system involvement by non-Hodgkin lymphoma.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; | 2015 |
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherap | 2015 |
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherap | 2015 |
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherap | 2015 |
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherap | 2015 |
High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma--a randomized phase III trial (MATRix).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neop | 2016 |
High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous | 2016 |
Long-term outcomes after thiotepa-based high-dose therapy (HDT) and autologous hematopoietic cell transplantation (auto-HCT) in non-Hodgkin lymphoma (NHL).
Topics: Adult; Aged; Autografts; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; | 2017 |
A novel preparative regimen for autologous transplant in non-Hodgkin's lymphoma: long-term experience with etoposide and thiotepa.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Etoposide; Female; | 2004 |
MATILDE regimen followed by radiotherapy is an active strategy against primary CNS lymphomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neop | 2006 |
[Lymphatic interventional radiology in the treatment of lymphatic neoplasmas].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Lymphatic M | 1995 |
Randomized trial showing equivalent efficacy of filgrastim 5 micrograms/kg/d and 10 micrograms/kg/d following high-dose chemotherapy and autologous bone marrow transplantation in high-risk lymphomas.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carm | 1997 |
A novel high-dose chemotherapy protocol with autologous hematopoietic rescue in patients with metastatic breast cancer or recurrent non-Hodgkin's lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms | 1997 |
Allogeneic transplantation for recurrent or refractory non-Hodgkin's lymphoma with poor prognostic features after conditioning with thiotepa, busulfan, and cyclophosphamide: experience in 44 consecutive patients.
Topics: Adult; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Disease-Free Survival; Drug Therapy, | 1997 |
Non-AIDS-related lymphomatous meningitis: combined modality therapy.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Comb | 1997 |
Randomized trial of peripheral blood progenitor cell vs bone marrow as hematopoietic support for high-dose chemotherapy in patients with non-Hodgkin's lymphoma and Hodgkin's disease: a clinical and molecular analysis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Marrow; Bone Ma | 1999 |
Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neoplasms; C | 2001 |
Treatment of aggressive non-Hodgkin's lymphoma in elderly patients with thiotepa, Novantrone (mitoxantrone), vincristine, prednisone (TNOP).
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Lymphoma, N | 2001 |
56 other studies available for thiotepa and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
Primary leptomeningeal lymphoma masquerading as infectious tubercular meningitis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, | 2021 |
[Molecular pathogenesis and therapeutic development of primary central nervous system lymphoma: update and future perspectives].
Topics: Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Combined Chemotherapy Protocols; Central N | 2022 |
[Busulfan/thiotepa followed by autologous peripheral blood stem cell transplantation for refractory diffuse large B-cell lymphoma accompanied by hypopyon].
Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cyclophosphamide; Doxorubicin; Humans; Lym | 2022 |
Long-Term Results with Thiotepa-Containing Conditioning Regimens for Autologous Stem Cell Transplantation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Etoposide; Hematopoietic Ste | 2023 |
Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cohort Studies; Cyclop | 2021 |
High-dose Thiotepa, Busulfan, Cyclophosphamide, and Autologous Stem Cell Transplantation as Upfront Consolidation for Systemic Non-Hodgkin Lymphoma With Synchronous Central Nervous System Involvement.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System; Combi | 2017 |
High-Dose Chemotherapy with Autologous Stem Cell Transplantation in Primary Central Nervous System Lymphoma: Data From the Japan Society for Hematopoietic Cell Transplantation Registry.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Femal | 2019 |
A Tale of Two Eras: The Story of Autologous Stem Cell Transplantation with and without Thiotepa for Primary Central Nervous System Lymphoma.
Topics: Antineoplastic Agents, Alkylating; Central Nervous System Neoplasms; Hematopoietic Stem Cell Transpl | 2019 |
Primary central nervous system lymphoma in an immunocompetent 12-year-old boy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Basal Ganglia; Brain Neoplasms; Child; Cytarabine; H | 2014 |
A new prognostic model using absolute lymphocyte count in patients with primary central nervous system lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neopla | 2016 |
High-dose chemotherapy with BEAM or Busulphan/Melphalan and Thiotepa followed by hematopoietic cell transplantation in malignant lymphoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Busu | 2008 |
Excessive toxicity of once daily i.v. BU, melphalan and thiotepa followed by auto SCT on patients with non-Hodgkin's lymphoma.
Topics: Adult; Busulfan; Female; Hematopoietic Stem Cell Transplantation; Hepatic Veno-Occlusive Disease; Hu | 2010 |
Autologous stem cell transplantation with thiotepa, busulfan, and cyclophosphamide (TBC) conditioning in patients with CNS involvement by non-Hodgkin lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neopla | 2012 |
High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk non-Hodgkin lymphoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carboplatin; Disease-Free Survival; Etoposide; Femal | 2012 |
Treatment of Hodgkin's granuloma, chronic lymphatic leukaemia, polycythaemia vera, and other reticuloses with triethylenethiophosphoramide.
Topics: Antineoplastic Agents; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Ce | 1956 |
Treatment of Hodgkin's granuloma, chronic lymphatic leukaemia, polycythaemia vera, and other reticuloses with triethylenethiophosphoramide.
Topics: Antineoplastic Agents; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Ce | 1956 |
Treatment of Hodgkin's granuloma, chronic lymphatic leukaemia, polycythaemia vera, and other reticuloses with triethylenethiophosphoramide.
Topics: Antineoplastic Agents; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Ce | 1956 |
Treatment of Hodgkin's granuloma, chronic lymphatic leukaemia, polycythaemia vera, and other reticuloses with triethylenethiophosphoramide.
Topics: Antineoplastic Agents; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Ce | 1956 |
[Experience in the use of the preparation thioTEPA in various diseases in children].
Topics: Antineoplastic Agents; Child; Hodgkin Disease; Humans; Infant; Lymphoma, Large B-Cell, Diffuse; Lymp | 1961 |
[EXPERIMENTAL STUDIES ON THE ANTITUMOR EFFECT OF OLIVOMYCIN IN ASSOCIATION WITH SOME SYNTHETIC CYTOSTATIC PREPARATIONS].
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Busulfan; Cytost | 1963 |
METHODOLOGY OF PRELIMINARY CHEMOTHERAPEUTIC TRIALS IN PATIENTS WITH MALIGNANT SOLID TUMORS.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Colonic Neoplasms; Cyclophosp | 1963 |
[TEST OF THE ACTION OF SOME NITROGEN MUSTARD DERIVATIVES ON STICKER'S LYMPHOSARCOMA].
Topics: Animals; Cyclophosphamide; Dogs; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Neoplasms; Neopla | 1963 |
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambuci | 1963 |
[SURVIVAL TIME AND ABILITY TO WORK IN HEMOBLASTOSES TREATED BY CHEMOTHERAPY].
Topics: Antineoplastic Agents; Aziridines; Biomedical Research; Cyclophosphamide; Genetic Diseases, X-Linked | 1963 |
THE INTRALYMPHATIC ADMINISTRATION OF RADIOACTIVE ISOTOPES AND CANCER CHEMOTHERAPEUTIC DRUGS.
Topics: Abdominal Neoplasms; Angiography; Breast Neoplasms; Geriatrics; Gold; Humans; Injections; Iodine Iso | 1964 |
A LABORATORY EVALUATION OF 1,4-DIMETHYL-1,4-DIPHENYL-2-TETRAZENE (CENTRAZENE), A CARCINOSTATIC COMPOUND.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Carcinoma 256, Walker; Lymphoma, Non-Hodgkin; Ma | 1964 |
FURTHER STUDIES ON THE EFFECT OF THIOTEPA ON THE SYNTHESIS OF PROTEIN AND NUCLEIC ACIDS IN TUMOR-BEARING MICE.
Topics: Animals; DNA; DNA, Neoplasm; Glycine; Lymphoma, Non-Hodgkin; Metabolism; Mice; Neoplasm Proteins; Ne | 1964 |
ANTITUMOROUS SUBSTANCES WITH RADIOMIMETIC AND RADIOPROTECTIVE GROUPS.
Topics: Acetylcholine; Antineoplastic Agents; Blood Pressure; Carcinoma 256, Walker; Cats; Erythropoiesis; L | 1964 |
EXPERIMENTAL STUDY OF OLIVOMYCIN, AN ANTITUMOUR ANTIBIOTIC.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Busulfan; Carcin | 1964 |
[STUDY OF VARIATIONS IN THE COMPLEMENT LEVEL IN THE COURSE OF CANCER CHEMOTHERAPY].
Topics: Animals; Breast Neoplasms; Bronchial Neoplasms; Complement System Proteins; Cyclophosphamide; Dexame | 1964 |
THE CHEMOTHERAPY OF CANCER WITH MASSIVE DOSES UNDER THE PROTECTION OF PERFUSION OF AUTOGENOUS HEMATOPOIETIC TISSUE.
Topics: Adenine; Bone Marrow Transplantation; Breast Neoplasms; DNA; Female; Folic Acid; Humans; Lung Neopla | 1964 |
[RETICULOSARCOMA OF THE STOMACH].
Topics: Drug Therapy; Gastrectomy; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms; Pathol | 1964 |
[EXPERIENCE WITH ETHYLENEIMINES].
Topics: Animals; Antineoplastic Agents; Aziridines; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Leukemi | 1964 |
MULTIPLE TRACHEOBRONCHIAL MELANOMAS WITH TEN-YEAR SURVIVAL.
Topics: Bronchial Neoplasms; Cheek; Cobalt Isotopes; Drug Therapy; Head and Neck Neoplasms; Lymphedema; Lymp | 1965 |
High-dose thiotepa, melphalan and carboplatin (TMCb) followed by autologous peripheral blood stem cell transplantation in patients with lymphoma -- a retrospective evaluation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Combined Modality Th | 2004 |
High dose chemotherapy and autologous stem cell transplantation for poor risk and recurrent non-Hodgkin's lymphoma: a single-center experience of 50 patients.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cyclophos | 2004 |
High dose chemotherapy with thiotepa, mitoxantrone and carboplatin (TMJ) followed by autologous stem cell support in 100 consecutive lymphoma patients in a single centre: analysis of efficacy, toxicity and prognostic factors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Carboplatin; Disease | 2004 |
Allogeneic bone marrow transplantation for refractory and recurrent low-grade lymphoma: the case for aggressive management.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; Cispla | 1995 |
Multiple cycles of high dose chemotherapy supported by hematopoietic progenitor cells as treatment for patients with advanced malignancies.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Breast Neoplasms; Cyclopho | 1995 |
High-dose busulfan, melphalan, and thiotepa followed by autologous peripheral blood stem cell transplantation in patients with aggressive lymphoma or relapsed Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Combined Modality | 1997 |
Safety and efficacy of a continuous infusion, patient controlled anti-emetic pump to facilitate outpatient administration of high-dose chemotherapy.
Topics: Adult; Ambulatory Care; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasm | 1999 |
Inappropriate antidiuretic hormone secretion after high-dose thiotepa.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; C | 1999 |
Intrathecal thiotepa: reappraisal of an established therapy.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Cerebrospinal Fluid; Child; Child, Preschool; Cohort | 2002 |
[Potentiation of the antitumor action of alkylating compounds by amphotericin B].
Topics: Alkylating Agents; Amphotericin B; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cycloph | 1977 |
[High-dose thio-TEPA with escalating doses of epirubicin and autologous hematopoietic stem cell transplant for refractory cancers].
Topics: Adolescent; Adult; Bone Marrow Transplantation; Breast Neoplasms; Drug Administration Schedule; Epir | 1992 |
High-dose hydroxyurea in autologous bone marrow transplantation: a promising "new" agent.
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplanta | 1992 |
High-dose tri-alkylator chemotherapy with autologous stem cell rescue in patients with refractory malignancies.
Topics: Adult; Alkylating Agents; Carmustine; Combined Modality Therapy; Cyclophosphamide; Female; Hematopoi | 1990 |
[High-dose cyclophosphamide, thio-TEPA, etoposide with autologous bone marrow transplantation for refractory cancers].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms | 1990 |
[Mitomycin alone and in therapeutic association in the palliative treatment of solid tumors].
Topics: Antineoplastic Agents; Breast Neoplasms; Cobalt Isotopes; Cyclophosphamide; Drug Combinations; Femal | 1971 |
[Antitumor action of berberinol thiophosphamide in experimental tumors in mice].
Topics: Adenocarcinoma; Animals; Body Weight; Carcinoma, Ehrlich Tumor; Dose-Response Relationship, Drug; Fe | 1974 |
[Experimental study of antitumor action of rubomycin in combination with some cytostatic compounds].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Busulfan; Drug Synergism; Lymphoma, Non | 1967 |
[On selection of antineoplastic agents for local use].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Female; Fluorouracil; In Vitro Techniques; | 1969 |
[The hypoplastic state of hematopoiesis following chemotherapy with alkylating compounds].
Topics: Adult; Aged; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Female; Hematologic Disease | 1969 |
Gastroscopic color photography in cancer chemotherapy.
Topics: Adenocarcinoma; Color; Cyclophosphamide; Fluorouracil; Follow-Up Studies; Gastroscopy; Humans; Lymph | 1970 |
[The results of treatment of maxillary sarcomas].
Topics: Adolescent; Adult; Aged; Child; Fibrosarcoma; Giant Cell Tumors; Hemangiosarcoma; Humans; Lymphoma, | 1970 |
[The anti-tumor effect of several mono- and di-chlor-sym.triazine derivatives].
Topics: Animals; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Female; Leukopenia; Lung Neoplasms; Lympho | 1970 |
[Resistance of malignant tumors to chemotherapeutic effects].
Topics: Animals; Lymphoma, Non-Hodgkin; Male; Rats; Sarcoma, Experimental; Thiotepa | 1970 |
Combination chemotherapy with L-asparaginase (EC-2) using P1798 lymphosarcoma.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cyclophosphami | 1971 |
[The efficacy of intralymphatic use of antiblastic drugs].
Topics: Animals; Antineoplastic Agents; Cats; Cyclophosphamide; Dogs; Female; Gold Colloid, Radioactive; Hod | 1969 |