thiotepa has been researched along with Diarrhea in 3 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paclitaxel, an effective chemotherapeutic agent in the management of breast carcinoma, may have activity in women whose disease has recurred after high dose chemotherapy." | 9.08 | A Phase I dose escalation trial of continuous infusion paclitaxel to augment high dose cyclophosphamide and thiotepa plus stem cell rescue for the treatment of patients with advanced breast carcinoma. ( Grinblatt, DL; Malloy, R; Williams, SF; Zimmerman, TM, 1998) |
| "The dose-limiting toxicities were interstitial pneumonitis and mucositis with moderately severe diarrhea (n = 3) and rash (n = 3)." | 6.69 | Repetitive high-dose therapy with cyclophosphamide, thiotepa and docetaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer: results of a phase I study. ( Blakey, D; Brettell, M; Briggs, P; Chapple, P; Eerhard, S; Gates, P; Januszewicz, EH; Juneja, S; Prince, HM; Quinn, M; Richardson, G; Rischin, D; Scarlett, J; Seymour, JF; Toner, GC; Wolf, M, 2000) |
| "Paclitaxel, an effective chemotherapeutic agent in the management of breast carcinoma, may have activity in women whose disease has recurred after high dose chemotherapy." | 5.08 | A Phase I dose escalation trial of continuous infusion paclitaxel to augment high dose cyclophosphamide and thiotepa plus stem cell rescue for the treatment of patients with advanced breast carcinoma. ( Grinblatt, DL; Malloy, R; Williams, SF; Zimmerman, TM, 1998) |
| "The dose-limiting toxicities were interstitial pneumonitis and mucositis with moderately severe diarrhea (n = 3) and rash (n = 3)." | 2.69 | Repetitive high-dose therapy with cyclophosphamide, thiotepa and docetaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer: results of a phase I study. ( Blakey, D; Brettell, M; Briggs, P; Chapple, P; Eerhard, S; Gates, P; Januszewicz, EH; Juneja, S; Prince, HM; Quinn, M; Richardson, G; Rischin, D; Scarlett, J; Seymour, JF; Toner, GC; Wolf, M, 2000) |
| "Current treatments for metastatic breast cancer are not associated with significant survival benefits despite response rates of over 50%." | 2.68 | High-dose chemotherapy supported by peripheral blood progenitor cells in poor prognosis metastatic breast cancer--phase I/II study. Edinburgh Breast Group. ( Anderson, E; Anderson, T; Cameron, DA; Chetty, U; Craig, J; Dixon, M; Gabra, H; Hawkins, A; Jack, W; Kunkler, I; Lee, L; Leonard, R; Leonard, RC; MacKay, J; Matheson, L; Miller, W; Parker, AC, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cameron, DA | 1 |
| Craig, J | 1 |
| Gabra, H | 1 |
| Lee, L | 1 |
| MacKay, J | 1 |
| Parker, AC | 1 |
| Leonard, RC | 1 |
| Anderson, E | 1 |
| Anderson, T | 1 |
| Chetty, U | 1 |
| Dixon, M | 1 |
| Hawkins, A | 1 |
| Jack, W | 1 |
| Kunkler, I | 1 |
| Leonard, R | 1 |
| Matheson, L | 1 |
| Miller, W | 1 |
| Zimmerman, TM | 1 |
| Grinblatt, DL | 1 |
| Malloy, R | 1 |
| Williams, SF | 1 |
| Prince, HM | 1 |
| Rischin, D | 1 |
| Toner, GC | 1 |
| Seymour, JF | 1 |
| Blakey, D | 1 |
| Gates, P | 1 |
| Eerhard, S | 1 |
| Chapple, P | 1 |
| Quinn, M | 1 |
| Brettell, M | 1 |
| Juneja, S | 1 |
| Wolf, M | 1 |
| Januszewicz, EH | 1 |
| Richardson, G | 1 |
| Scarlett, J | 1 |
| Briggs, P | 1 |
3 trials available for thiotepa and Diarrhea