thiotepa has been researched along with Depression in 3 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ThioTEPA-treated mice subjected to an object recognition test 1, 2, 3, 4, 8, 12, 20 or 30 weeks following treatment demonstrated significant memory deficits at 12 and 20 weeks." | 5.36 | The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice. ( Gulinello, ME; Mondie, CM; Vandergrift, KA; Weber, ET; Wilson, CL, 2010) |
| "From a randomized study in high-risk breast cancer patients on the efficacy of high-dose versus standard-dose adjuvant chemotherapy, late effects on cognitive functioning were analyzed by neuropsychological tests." | 2.70 | Neurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function. ( Boogerd, W; Hamburger, HL; Muller, MJ; Schagen, SB; van Dam, FS, 2001) |
| "ThioTEPA-treated mice subjected to an object recognition test 1, 2, 3, 4, 8, 12, 20 or 30 weeks following treatment demonstrated significant memory deficits at 12 and 20 weeks." | 1.36 | The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice. ( Gulinello, ME; Mondie, CM; Vandergrift, KA; Weber, ET; Wilson, CL, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mondie, CM | 1 |
| Vandergrift, KA | 1 |
| Wilson, CL | 2 |
| Gulinello, ME | 1 |
| Weber, ET | 2 |
| Schagen, SB | 1 |
| Hamburger, HL | 1 |
| Muller, MJ | 1 |
| Boogerd, W | 1 |
| van Dam, FS | 1 |
1 trial available for thiotepa and Depression
| Article | Year |
|---|---|
Neurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function.
Topics: Alpha Rhythm; Antineoplastic Combined Chemotherapy Protocols; Anxiety; Breast Neoplasms; Carboplatin | 2001 |
2 other studies available for thiotepa and Depression
| Article | Year |
|---|---|
The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Bromodeoxyuridin | 2010 |
Chemotherapy drug thioTEPA exacerbates stress-induced anhedonia and corticosteroid responses but not impairment of hippocampal cell proliferation in adult mice.
Topics: Adrenal Cortex Hormones; Anhedonia; Animals; Antineoplastic Agents, Alkylating; Cell Proliferation; | 2013 |