thiotepa has been researched along with Chronic Disease in 12 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty patients with high-risk hematologic malignancies, underwent an unmanipulated haploidentical bone marrow transplantation (BMT), followed by posttransplantation high-dose cyclophosphamide (PT-CY): the myeloablative (MA) conditioning consisted of thiotepa, busulfan, fludarabine (n = 35), or total body irradiation (TBI), fludarabine (n = 15)." | 5.17 | Unmanipulated haploidentical bone marrow transplantation and posttransplantation cyclophosphamide for hematologic malignancies after myeloablative conditioning. ( Bacigalupo, A; Ballerini, F; Bregante, S; Di Grazia, C; Dominietto, A; Geroldi, S; Ghiso, A; Gualandi, F; Lamparelli, T; Luchetti, S; Miglino, M; Raiola, AM; Van Lint, MT; Varaldo, R, 2013) |
| " The following protocols are proposed: CIRP (colchicine in recurrent pericarditis)--colchicine vs placebo in chronic/recurring pericarditis without pericardiocentesis; TRIPE (triamcinolone in pericardial effusion)--intrapericardial instillation of triamcinolone + 6 months colchicine vs pericardial puncture without instillation + 6 months colchicine; NEPIN (neoplastic effusion and pericardial instillation)--pericardiocentesis and drainage + intrapericardial instillation of cisplatin or thiotepa." | 3.70 | New directions in diagnosis and treatment of pericardial disease. A project of the Taskforce on Pericardial Disease of the World Heart Federation. ( Maisch, B; Ristić, AD; Seferovic, PM, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pagliardini, T | 1 |
| Castagna, L | 1 |
| Harbi, S | 1 |
| Porta, MD | 1 |
| Rey, J | 1 |
| Fürst, S | 1 |
| Bramanti, S | 1 |
| Saillard, C | 1 |
| Legrand, F | 1 |
| Maisano, V | 1 |
| Faucher, C | 1 |
| Granata, A | 1 |
| Hospital, MA | 1 |
| Lining, W | 1 |
| Weiller, PJ | 1 |
| Calmels, B | 1 |
| Charbonnier, A | 1 |
| Lemarie, C | 1 |
| Chabannon, C | 1 |
| Vey, N | 1 |
| Mokart, D | 1 |
| Blaise, D | 1 |
| Devillier, R | 1 |
| Piñana, JL | 1 |
| Sanz, J | 1 |
| Esquirol, A | 1 |
| Martino, R | 1 |
| Picardi, A | 1 |
| Barba, P | 1 |
| Parody, R | 1 |
| Gayoso, J | 1 |
| Montesinos, P | 1 |
| Guidi, S | 1 |
| Terol, MJ | 1 |
| Moscardó, F | 1 |
| Solano, C | 1 |
| Arcese, W | 1 |
| Sanz, MA | 1 |
| Sierra, J | 1 |
| Sanz, G | 1 |
| Raiola, AM | 1 |
| Dominietto, A | 1 |
| Ghiso, A | 1 |
| Di Grazia, C | 1 |
| Lamparelli, T | 1 |
| Gualandi, F | 1 |
| Bregante, S | 1 |
| Van Lint, MT | 1 |
| Geroldi, S | 1 |
| Luchetti, S | 1 |
| Ballerini, F | 1 |
| Miglino, M | 1 |
| Varaldo, R | 1 |
| Bacigalupo, A | 1 |
| Wilson, CL | 1 |
| Weber, ET | 1 |
| ZARAFONETIS, CJ | 1 |
| SHAY, H | 1 |
| SUN, DC | 1 |
| Bunin, N | 1 |
| Aplenc, R | 1 |
| Grupp, S | 1 |
| Pierson, G | 1 |
| Monos, D | 1 |
| Maisch, B | 1 |
| Ristić, AD | 1 |
| Seferovic, PM | 1 |
| Nemchinov, NN | 1 |
| Enderlin, M | 1 |
| Gross, D | 2 |
| Deicher, H | 1 |
| Fricke, R | 1 |
| Krull, P | 1 |
| Heydenreich, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Bone Marrow Transplantation HLA Haploidentical After a Reduced Intensity Conditioning and Prevention of GvHD Based on Post-transplant Cyclophosphamide Administration in Patients With Severe Sickle Cell Disease[NCT03240731] | Phase 2 | 18 participants (Anticipated) | Interventional | 2017-08-10 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for thiotepa and Chronic Disease
| Article | Year |
|---|---|
Thiotepa, Fludarabine, and Busulfan Conditioning Regimen before T Cell-Replete Haploidentical Transplantation with Post-Transplant Cyclophosphamide for Acute Myeloid Leukemia: A Bicentric Experience of 100 Patients.
Topics: Adult; Aged; Allografts; Busulfan; Chronic Disease; Cyclophosphamide; Disease-Free Survival; Female; | 2019 |
Umbilical cord blood transplantation in adults with advanced hodgkin's disease: high incidence of post-transplant lymphoproliferative disease.
Topics: Acute Disease; Adult; Antilymphocyte Serum; Busulfan; Chronic Disease; Cord Blood Stem Cell Transpla | 2016 |
Unmanipulated haploidentical bone marrow transplantation and posttransplantation cyclophosphamide for hematologic malignancies after myeloablative conditioning.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Agents; Bone Marrow Transplantation; Busulfan | 2013 |
Unrelated donor or partially matched related donor peripheral stem cell transplant with CD34+ selection and CD3+ addback for pediatric patients with leukemias.
Topics: Adolescent; Adult; Antigens, CD34; CD3 Complex; Child; Child, Preschool; Chronic Disease; Cyclophosp | 2006 |
8 other studies available for thiotepa and Chronic Disease
| Article | Year |
|---|---|
Chemotherapy drug thioTEPA exacerbates stress-induced anhedonia and corticosteroid responses but not impairment of hippocampal cell proliferation in adult mice.
Topics: Adrenal Cortex Hormones; Anhedonia; Animals; Antineoplastic Agents, Alkylating; Cell Proliferation; | 2013 |
Triethylene thiophosphoramide in the treatment of chronic leukemia.
Topics: Chronic Disease; Leukemia; Phosphorus; Phosphorus, Dietary; Thiotepa | 1955 |
New directions in diagnosis and treatment of pericardial disease. A project of the Taskforce on Pericardial Disease of the World Heart Federation.
Topics: Chronic Disease; Cisplatin; Clinical Trials as Topic; Colchicine; Heart Diseases; Heart Neoplasms; H | 2000 |
[Thiophosphamide in the overall treatment of chronic pneumonia].
Topics: Adult; Aged; Chronic Disease; Drug Hypersensitivity; Humans; Middle Aged; Pneumonia; Remission, Spon | 1976 |
[Contribution on the therapy of progressive chronic polyarthritis with antimetabolites and cytostatics].
Topics: Adolescent; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Betamethaso | 1967 |
[Treatment of chronic connective tissue diseases with cytostatics].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Chronic Disease; Collagen | 1970 |
Topical treatment of psoriasis with triethylenethiophosphoramide (Thio-Tepa).
Topics: Adult; Aged; Biopsy; Blood Cell Count; Blood Platelets; Chronic Disease; Female; Humans; Leukocyte C | 1971 |
[Intra-articular treatment of progressive chronic polyarthritis with cytostatic agents (thio-tepa)].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Chronic Disease; Humans; Injections, Intra-Articular; | 1966 |