thiotepa has been researched along with Chromosomal Translocation in 6 studies
Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Up to now, most of the chemicals tested have shown additive effects when combined with doses of the ascending part of the dose-response curve and potentiating effects when combined with doses of its descending part." | 1.28 | The induction of reciprocal translocations in mouse germ cells by chemicals and ionizing radiations. II. Combined effects of mitomycin C or thio-tepa with two doses of gamma-rays. ( Andrieu, JM; De Luca, JC; Dulout, FN; Furnus, CC; Ulrich, MA, 1990) |
| " The dose-response relationships after treatment with doses of 20, 40 and 60 mg/kg of the compound as well as the combined effect of BLM and gamma-rays and BLM and thio-tepa (TT) were studied." | 1.27 | The induction of reciprocal translocations in mouse germ cells by chemicals and ionizing radiations. I. Dose-response relationships and combined effects of bleomycin with thio-tepa and gamma-rays. ( Andrieu, JM; De Luca, JC; Dulout, FN, 1988) |
| "Structure chromosome aberrations were found in the cells of such embryos." | 1.26 | [Mutagenic effect of chemical compounds on laboratory mice]. ( Malashenko, AM; Selezneva, GP; Semenov, KhKh; Surkova, NI, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malashenko, AM | 3 |
| Devi, KR | 1 |
| Reddy, PP | 1 |
| Goetz, P | 1 |
| Semenov, KhKh | 1 |
| Selezneva, GP | 1 |
| Surkova, NI | 1 |
| De Luca, JC | 2 |
| Dulout, FN | 2 |
| Ulrich, MA | 1 |
| Furnus, CC | 1 |
| Andrieu, JM | 2 |
6 other studies available for thiotepa and Chromosomal Translocation
| Article | Year |
|---|---|
[Interstrain differences in the sensitivity of male sex cells to induction of dominant lethals by thiophosphamide].
Topics: Animals; Genes, Dominant; Genes, Lethal; Genotype; Hybridization, Genetic; Male; Mice; Mice, Inbred | 1980 |
Evaluation of thiotepa for genetic damage in mice.
Topics: Animals; Chromosome Aberrations; Male; Metaphase; Mice; Mutagens; Thiotepa; Translocation, Genetic | 1980 |
Cytogenetic analysis of translocations induced by the chemical mutagen thio TEPA in spermatids of male mice.
Topics: Animals; Cytogenetics; Female; Heterozygote; Male; Meiosis; Metaphase; Mice; Mutagens; Spermatids; S | 1981 |
[Mutagenic effect of chemical compounds on laboratory mice].
Topics: Animals; Chromosome Aberrations; Embryonic Development; Female; Genes, Dominant; Genes, Lethal; Male | 1978 |
The induction of reciprocal translocations in mouse germ cells by chemicals and ionizing radiations. II. Combined effects of mitomycin C or thio-tepa with two doses of gamma-rays.
Topics: Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gamma Rays; Male; | 1990 |
The induction of reciprocal translocations in mouse germ cells by chemicals and ionizing radiations. I. Dose-response relationships and combined effects of bleomycin with thio-tepa and gamma-rays.
Topics: Animals; Bleomycin; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Sy | 1988 |